<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08962

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDWQSQQFRQSAIAKIKDLLQASGQHLDKNANVMENHIFKKSKSKEEYMTLLTKIYSHFKENSRKLTNEIPQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGGVPGQQQGNVVGGPSSQQQMMNQMVGPGGLQMNIMGGPGGPQQNQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGTVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQSGGPQSNQPLPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKYKQLTKYIEPLKRMVAKFSNDGAQIEGQTKMRKLLEILSNPSQRVSLETLLKCEKVLEKMEIGNIVQQFGKSPNPLMEVITNTLQSPIANHTLYRTFRPTLELLLGTDISAPPPLKKSKTTNSNETEIPHLLQGELARLDTKFKVSLDTTVQNNTKSIKLICCLDDKKLPSVPPINITIPEEYPLSSPDCILIEQDYSCTSFLKSVQSAFIARIAKLPKIYSLSHLLNTWEMSVRQACSPNTSKPICELTALFGM
Length765
PositionTail
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.03
Grand average of hydropathy-0.650
Instability index58.46
Isoelectric point9.46
Molecular weight82788.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08962
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     375.38|      48|      48|     166|     213|       1
---------------------------------------------------------------------------
  102-  163 (68.81/14.34)	GGG.PG.GpvtasnlLQSLNQQRPGQQQMQQMQGMRPQM......PMG..GG.VP....GQ.....Q.QGnvvGGP..SsqqqMM
  166-  213 (102.40/24.81)	MVG.PG.G.......LQMNIMGGPGGPQQNQMVGNAQQM......TAG..GS.GP....GV.....G.QG...LGP..G....QM
  216-  263 (64.74/13.07)	MVG.PGsG.......GPMG..SGAGGPNQMQMQAAAGQM......Q.....G.GPmnvhGM.....NvQQ...L.P..G....QM
  271-  307 (46.97/ 7.53)	MSM.QQ...................HSQLNQMM.NA.RM......NQA..GP.GG....NI.....T.VG...AGPtgG....AA
  310-  354 (45.89/ 7.20)	MQGlPG.N.......L...........QQNQGAGTVSQM......HSGnvSG.GP....QVpssamG.NN...AGQ..G....NL
  407-  454 (46.57/ 7.41)	.......G.......LTVQ..QQQQQQQLQQVVNNQQQLqqqqqqQAN..QSgGP....QS.....N.QP...LPN..A....QM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     314.50|      80|      86|     594|     674|       2
---------------------------------------------------------------------------
  496-  588 (85.45/41.80)	......NS.PFNPHeeQL...YREKYKQLTKYI.......EPLKRMVAK.FSNDgaqiegqTKMRKLL..EILS.NPSQRVSLETllkcekvlekmeignIVQQFGKSPNPLME
  589-  673 (121.99/66.18)	VitntLQS.PIANH..TL...YRTFRPTLELLLGTDISAPPPLKKSKTT.NSNE.......TEIPHLLQgELARLDTKFKVSLDT...............TVQNNTKSIKLICC
  674-  758 (107.06/54.01)	LddkkLPSvPPINI..TIpeeYPLSSPDC.ILIEQDYSCTSFLKSVQSAfIARI.......AKLPKIYS..LSHLLNTWEMSVRQ...............ACSPNTS..KPICE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.70|      35|      87|     368|     406|       3
---------------------------------------------------------------------------
  368-  406 (49.03/34.80)	PNMPL..AQNNQMFNVNRGVvGQQQfLRQSPSpSTVSSPaG
  456-  492 (61.68/27.46)	PSPALvpTSSPQMSGLMQNP.NQRQ.MRQSPS.SNLNTP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.87|      20|      29|      21|      40|       4
---------------------------------------------------------------------------
   21-   40 (33.93/25.80)	LLQASGQHLDKNANVMENHI
   53-   72 (32.94/24.82)	LLTKIYSHFKENSRKLTNEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08962 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KENSRKLTNEIPQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGGVPGQQQGNVVGGPSSQQQMMNQMVGPGGLQMNIMGGPGGPQQNQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGTVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQSGGPQSNQPLPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKY
62
511










Molecular Recognition Features






MoRF SequenceStartStop




NANANA