<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08961

Description Uncharacterized protein
SequenceMLSLLQEKRPLKRSRLGPPDVYPQEAKQREDELTPSNVNKGFASMPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSSSSEKALLSGQGAPTTQNNNASLTLSHSSNNATLVPSIASPVPMLSPANSQSSSSGGLGVLSSNSGSGVGTSSSQSSITGANQAPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDRMRTQANFDESLKRLVLTFALPYMQDFVQSERLCRKMAYIVAKKLTNLLNAVIDQQQSLTNGKSENTIHMEMDEEIDKKKSQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPIAMVWCGIGENRAPAALCGSPLDHLPVAPSVLPMPIKCPITNAEVRRQLRATEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLTILDYLDTHCFDRMDQTNSIDSLYANIFKTFVTMRREVGPNGEIKEIRHEYEANVVDGTTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNELDNNNGNAVAHSNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGLTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGVANVDSSKPSVTATTTVSGPVSNKASSPPGNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPTTSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFDGLCRTIKHVTNPSECSSAERCILAYLSDLYESCFLLKSKEQEPEFFQQMAAIKKFKDIFNAPEQLGTVPQAYNPQFLQELFTSPKRGGKIDSIWLHQLHESPSNVYSFVSNAIVAVCHEADNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPHFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTAVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSMNNPAELSSWLDTVARAAIDVFLMEEVVVGSGLKSEHRPKASTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSNSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVVDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVTPTLFLQKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTGHNPQQQQWPGQNQFHPMQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQSLGAQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNANIMASQNNTGLVNASAMMQQNVGVGGGAVGQNMVNQNAAQFQNFSQYQHQAINQSGNSNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGSVPPGMTQPQNQSVGQQQTPNLVAHLQQRSMLNQPSMMGQQYQHQPPPY
Length2342
PositionKinase
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index48.76
Isoelectric point6.39
Molecular weight260177.73
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08961
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     209.22|      21|      21|    2213|    2233|       1
---------------------------------------------------------------------------
 1989- 2011 (22.41/ 7.52)	MgfMGS........NG.PQGMAQTgHNPQQQQ
 2012- 2031 (35.52/17.37)	W..PGQ........NQFHP.MQQQ.QQQQFYQ
 2069- 2085 (23.08/ 8.03)	N.............NSAAFNTMQ..QQQRQTQ
 2092- 2108 (24.08/ 8.78)	Q..TG...........VLNP.VQQ.QQLQQQQ
 2213- 2233 (35.66/17.47)	A..VGQ........NMVNQNAAQF.QNFSQYQ
 2236- 2264 (26.44/10.55)	A..INQsgnsnqqaNIVANFMAQQ.QQQQPPQ
 2265- 2282 (21.57/ 6.90)	R..GPA........GM.TSNRGQY...MSQAP
 2289- 2304 (20.46/ 6.06)	T..MGQ........GSVPPGMTQP.QN.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.16|      26|     247|    1948|    1973|       2
---------------------------------------------------------------------------
 1948- 1973 (55.46/30.22)	NSNQM.MQQ.........NPNAIIQQQQQMPG.VPSG
 2164- 2200 (29.71/12.35)	NNNQMiMNQnagvmstgnNQNANIMASQNNTGlVNAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.27|      15|      19|    1108|    1126|       3
---------------------------------------------------------------------------
 1108- 1126 (21.55/19.35)	GTVPQAYnpqfLQELFTSP
 1130- 1144 (28.72/14.05)	GKIDSIW....LHQLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.54|      19|      19|    2124|    2142|       4
---------------------------------------------------------------------------
 2124- 2142 (34.62/20.47)	GAAPNQMAPGINTVGMGSQ
 2145- 2163 (34.92/20.72)	GAQNPIMQQQISAQTMNPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.64|      21|      22|     258|     278|       5
---------------------------------------------------------------------------
  258-  278 (37.17/23.09)	SQSSSSG.GLGVLSSNSGSGVG
  282-  303 (33.47/19.92)	SQSSITGaNQAPVSGSSISGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.46|      19|      19|    1381|    1399|       6
---------------------------------------------------------------------------
 1381- 1399 (32.07/20.19)	ERPVDLSQILGT..SDLNSLN
 1401- 1421 (29.39/17.78)	EHDHDMTQQLTStpSNTGALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.78|      35|     250|    1344|    1379|       7
---------------------------------------------------------------------------
 1344- 1379 (59.89/45.19)	KTSNMSGNSS.GG....AFGTTGGKRSGFSTPVHpGSTPKS
 1599- 1638 (50.89/32.08)	KVSKSDNNSScSGdereKSNSCGSASSSYSIGVN.GSNSRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.66|      27|     250|     218|     255|       9
---------------------------------------------------------------------------
  222-  248 (46.59/43.76)	PTTQNNNASLTLSHSSNN.ATLVPSIAS
  644-  671 (44.07/15.43)	PNELDNNNGNAVAHSNNNlNDDKDSIAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.45|       9|      16|    2039|    2048|      11
---------------------------------------------------------------------------
 2039- 2048 (15.48/14.56)	MNRFERPPhM
 2058- 2066 (19.97/12.07)	MLRHRQPP.M
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.05|      31|     177|    1680|    1710|      15
---------------------------------------------------------------------------
 1680- 1710 (54.10/44.92)	SYTEFDTMGGVDDPLGREEMLDALQLR.FS.....LV
 1819- 1845 (20.40/10.99)	.........GVDQKGNKINDMDKKQLR.ISdkqriSV
 1859- 1890 (48.55/39.34)	SWVWFGAVKLERKPLTYEEAHRNLKYHtHS.....LV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     195.47|      67|     466|     417|     495|      17
---------------------------------------------------------------------------
  417-  495 (98.00/103.26)	EMDEEIDK...KKSQLDpyevaINEYLNCPHH.RDIILYLSTILQ..........VITVECPIAMVwcgigENRAPAALcGSPlDHLPVAPSV
  886-  966 (97.47/65.86)	KMSKEICKlftKKFSID.....VAEGGKVKKHsRNEFNFEATTSKcqnmayfdqhVVTSQCAATVL.....EQLNAFAL.GSN.NYLPVQEHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.62|      10|      21|     743|     752|      27
---------------------------------------------------------------------------
  743-  752 (18.67/10.68)	G.VANVDSSKP
  762-  772 (14.95/ 6.83)	GpVSNKASSPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08961 with Med12 domain of Kingdom Metazoa
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