<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08942

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASSSAGPGTGQATSTAPGGNGNIDASNHASSSTGPSTKGPRNPQLGNEPWFAYPTPTPEQIEDELPPYFEGENAPLGPLLNRLVRKGYGDLRYLLAEVLPPLSAKQKPKHIINYATTTRQALLKYLAVLRWKAAVDVRSSSAAASSSSSVNHASNQINGPNGNFNNFPTPHSNGDDTSPASVSSNNKGKGKAIIGSGDNEDVLVKGKVTDSRRLAQFMEHQNRQHDDAVVHLQHVTKLVESLRERNPDLLTAIALLTTGTYNRLPTSITEPFIPKPPLTNSAILKLLKRLNRHIKYRLRCTEYIPPELVVEGIEDGQVYFTGGGENGWRIRMTIVGFGVESKWWLTGVEWRWRHREKGVDDPGGESDATKAGKIFTGEERQSILDLANLEILPPRDTIQEDIQAKEVSQGTGQKTQGDQVAIKDQVVDAPLVRIYNFIQHLSLSYQLEILFTQAMSLSVGKWRNQLRVEIDRETKTLKVKYWIRPRPAVIAQQQQAAVGKRPPPAASAGAARSPLVGGILSISLNEANVSQNEADSFIADIASGGLTPSERVLSLRLGLRWEVGELGAGGGLRVGDVMDGGVLQIDPASLDMETLILTSARAHAAHLTRVQASSLVSSPKFILSLLNQPTLQETEDPDSSCPLTLRIPLPSRLNVSSLLIGVSAYSGYVEIEDDGSIGNEARANRVELATKSINDGKTRLVDDIGRLTVAIVMENLEDQMRQLGWKPIRRLALRSQDLAKVQLHPATTILIPVLSSPAYYFVTKVTQSGLAFEMLKVIKVPSESGMGIGMKSAVDDRVPLDLERLRSREKGKEVEATLNTSPFEIGNKDLKNLFIYSNALVAQTIIENQLKERNIPFTAQYPSAIQSSSGASSTRSTSALAGMVPTICVDVRDLLRDGKRGAAVDVAMPKVGMQIENWWTGGRCEVTTIVRLQQQSSMAQTPTTSRDTSTNSSQAHSEDISFDPASSIVKFRAKDIERCVPAFLEQWERLSKVIVVAGEVNRLNKYAEFSDIKMLSFDLRTATLSYAKEYKASITYVPVDDSYQVLLSKTSAQSSSSPSISTTNLEDNNPHERLSSLLSARLTELASTPLLDVPKGAVGREFFGLLKNTLPFFQQVNPLKGRGWELIILDIRTYRIFKDYKGRRYALDVILIPALSHYLIQSSSKPKGPDRRPDIEITGPITELPLKQIVPQIFDALKPTIPSSSSAAPAHGIGIGIPPLIRLDRNQSLMCRVDMIESVLSELVDRVDDHIGIKRDQEGSA
Length1262
PositionTail
OrganismKwoniella dejecticola CBS 10117
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.300
Instability index44.77
Isoelectric point8.35
Molecular weight138083.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      12|      17|      41|      52|       2
---------------------------------------------------------------------------
   41-   52 (26.23/15.96)	PRNPQLGNE..PWF
   57-   70 (19.60/ 9.95)	PTPEQIEDElpPYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.03|      25|     307|      71|     102|       3
---------------------------------------------------------------------------
   74-  102 (38.95/45.71)	NAPLGPLLNRLVRKgygdLRYLL..AEVLPP
  281-  307 (40.09/23.42)	NSAILKLLKRLNRH....IKYRLrcTEYIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.39|      63|     112|    1002|    1064|       6
---------------------------------------------------------------------------
 1002- 1064 (102.08/76.79)	NRLNKYAEFSDIK.....MLSFDLRTATL..SY.AKEYKASITYVPVDDSYQVLLSKTSAQSSSSPSISTT
 1109- 1179 (92.31/68.59)	NTLPFFQQVNPLKgrgweLIILDIRTYRIfkDYkGRRYALDVILIPALSHYLIQSSSKPKGPDRRPDIEIT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08942 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAASSSSSVNHASNQINGPNGNFNNFPTPHSNGDDTSPASVSSNNKGKGKAIIGS
2) MASSSAGPGTGQATSTAPGGNGNIDASNHASSSTGPSTKGPRNPQLGNEPWFAYPTPTPE
143
1
197
60










Molecular Recognition Features






MoRF SequenceStartStop




1) EPWFAYPTP
2) QIEDELP
49
61
57
67