<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08933

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMIDFLGGEPPRPTTIIPNQWIIDLPAPDTQIHIRQYRAPPENGQVSAGPSTSTPSSSSIFRDVLVDPFERAWRLINDHPDNNEIPAIHNALSRPCAVIANEGGEKMLYHFSNAGAGHSEGESEVPAYEGLEEITPAPQLLSITQLVSCSQHGHDPSCLDPKPLDTGAISTCKVSLDLSGGVSRHLELLASALVEKIAWQQGKGSRLLTQSSFTSSYTSFNSSLRPISSQRFLLSVNPPRQPSSSTTHTPTPLLLSPLNLPALLLCPSSLTSTQESHLISSFDSAFGHTWKEGRSERRTRSLMLGESYSDWSIYWVPLDSIEKWQSFQGVLTIWPTHLSHPYFLCSASTIRRPIARPHTDATTHTDLLGISAGLFDFMSTYKEPDPPPDGDGDGDGEDEDEEEDVNMDAESTVITAEADSDQILQQANLPEVNEVESDLDDLFSAHSDSPNVTIIPDQVLDQPILSMMDTDPPIESLDGYITSMPITSSGDNNRQLSRNGTENGQKEEMVTEDDFAFFDSPTDAVDISTDPNDVSAEMTQKNPTIDDHTMAIDGSLPPRNEWATLNPPVSDASDTKDAASEEQPLEMIVQDQATEEALQAAVNGKKIAVAEKQQNLPTTLIASPPPTAIPKLPSPPTPSPPPTELPSSWLTTDLIPPTFSPLPLLPLSDSPFPYSLPTPAPTPSSLNWDLVERLQPPKSNKPTYADDWNMEDEQSDLDEEDPYTDPPTPITDYTTDSEEEITCNQKAKAQPNDIAEGHDHEIESSGARCVGAEWLHLVYELAKLNDIAQLWNSSWIKAHEVLPILPPTPPEEVSRKNWLKGLDVGRFVKQILGNTNMRSSSLCLRLGSSSLSQTSTWAALVEKNCMTLADLSHDVKTRPLPQPQISAGYHHYSINLNISSLQYWTELGLQPHGGHKDVKAVFLCDDSPGSTQRAASAGAEIGRAWRELHFGSHELADDAIISAKSTVMVEAAANVLNQSPDDTVLYIVLPHNPPTKLIRGLFNYAISPAPSTVVHLLPQHSLTASQYKTVASEVYNKVSESIREINARSVPDPYGLHHSSSDSDSHENDDRIARQAFTLARSENPTPEFSMSWPLKSYDVLNNNRFIHSAYTVDEDLGIMIGFMMDDLGNMSDVNTWTDIAKMKWENRVEKLWKWAKAKADKWVIQWRLSVMRCGGMVNDELKAWRKILQDGNLPITLLLTAGLESEEASDANEDEDIPRPKGFTNIPPATLNDPSSSIIDLAHAAQLTILGNKLPIDLIASSASPATSTSTSTSTASQEVIYPISSFLLTLSQSQGSESQTTLYNVIHHQEPPSNPVGPWFASTTTKKKDGKESDDAVKLENELGEEIYRIGCLIFAKWGIRGGIKGVLGMAVKELKVLSLSEME
Length1385
PositionKinase
OrganismKwoniella dejecticola CBS 10117
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cryptococcaceae> Kwoniella.
Aromaticity0.06
Grand average of hydropathy-0.435
Instability index50.49
Isoelectric point4.64
Molecular weight151858.52
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1049.69|     168|     168|     609|     776|       1
---------------------------------------------------------------------------
  237-  425 (109.61/51.24)	..........................................PPR.Q.PS........SSTT.......HT...P..TPLL....LS.............................PLNL....PALL.LCPSSLtstqeshlissfDS.AFGHT..WKEGRSERRT..RSlmlgesyS...DWSI...YWV...PLDSIEKWQS..........FQ........GVLT..IWPTHlSHPYFLCSastirrpiarphtdatthtdllgisaglfdfmstyKEP.DPP.PDGDGDGDGEDEDEEEDVN.MDAE..........................stvitaeadsdqilQQ
  426-  612 (167.85/83.30)	A..NLP..E............VNE..VESDLDDLFSAHSDSPNVT.IIPDqvldqpilSMMDTD..PPIESldgY..ITSMP...ITSS.........................GDNNRQ....LSRN.GTENGQ............KE.EMVTE..DDFAFFDSPT..DA...vdisT...DPN..D.VSA...EMTQKNPTIDdhtmaidgslPPrnewatlnPPVS..D.ASD......TKD...................................AAS.EEQ.PLEMI.VQDQATEEALQAA.VNGKKIAV....................AE..............KQ
  613-  780 (287.29/149.06)	Q..NLP..TTLI.........ASP..PPTAIPKLPSPPTPSPPPT.ELPS........SWLTTDLIPPTFS...P..LPLLP...LSDS.........................PFPYSL....PTPA.PTPSSL............NW.DLVER..LQPPKSNKPT..YA.......D...DWNMED.EQS...DLDEEDPYTD..........PP........TPIT..DYTTD.SEEEITCN...................................QKA.KAQ.PNDIAEGHDHEIESSGARC.VGAEWLHL....................VY..............EL
  781-  971 (168.03/83.40)	A..KLNdiAQLW.........NSS..WIKAHEVLPILP.PTPPEE.VSRK........NWL.KGLDVGRFV...KqiLGNTN...MRSS.........................SLCLRL....GSSS.LSQTS.............TWaALVEK........NCMT..LA.......DlshDVKTRPlPQP...QISAGYHHYS..........IN........LNISslQYWTE.LGLQPHGG...................................HKDvKAVfLCDDSPGSTQRAASAGAE..IGRAWRELhfgsheladdaiisakstvmVE..............AA
  972- 1144 (159.86/78.90)	A..NV.....LN.........QSP..DDTVLYIV....LPHNPPT.KLIR........GLFNYAISPAPST...V..VHLLPqhsLTASqyktvasevynkvsesireinarsvPDPYGL...hHSSS.DSDSHE............ND.DRIARqaFTLARSENPTpeFS.......M...SWPL...KSY...DVLNNNRFIH.......................S..AYTVD.EDLGIMIG........................................FM.MDDLGNMSDVNTWTDIAK....MKW.........................................
 1189- 1359 (157.05/77.35)	QdgNLP..ITLLltagleseeASDanEDEDIPR.PKGFTNIPPATlNDPS........SSI.IDLAHA..A...Q..LTIL......GN.........................KLPIDLiassASPAtSTSTST............ST.ASQEV..IYPISSFLLT..LS.......Q...SQGSES.QTTlynVIHHQEPPSN..........PV........GPWF..ASTTT.KKKDGKES...................................DDA.VKL.ENELGE....EIYRIG..ClIFAKW.........................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08933 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) STYKEPDPPPDGDGDGDGEDEDEEEDVNMDAESTVITAEADSDQILQQANLPEVNEVESDLDDLFSAHSDSPNVTIIPDQVLDQPILSMMDTDPPIESLDGYITSMPITSSGDNNRQLSRNGTENGQKEEMVTEDDFAFFDSPTDAVDISTDPNDVSAEMTQKNPTIDDHTMAIDGSLPPRNEWATLNPPVSDASDTKDAASEEQPLEMIVQDQATEEALQAAVNGKKIAVAEKQQNLPTTLIASPPPTAIPKLPSPPTPSPPPTELPSSWLTTDLIPPTFSPLPLLPLSDSPFPYSLPTPAPTPSSLNWDLVERLQPPKSNKPTYADDWNMEDEQSDLDEEDPYTDPPTPITDYTTDSEEEITCNQKAKAQPNDIAEGHDHEI
378
761










Molecular Recognition Features






MoRF SequenceStartStop




NANANA