Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MENVDQIKRPLEGVYLIDQEATYNAPNPTPLDNLLAMYDLELIASSLGRTKPDGSKGVKLRKSYKNHIQDLKGKHQIPPSKPLNGQILDPELAKIPDVITEFNPELLSAALKFDKTSINGIPGFSPSDLALSDQAASTRGDDNGESEEAKRKRKKKQLMGVEYKRHHI |
Length | 168 |
Position | Head |
Organism | Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Metschnikowia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.735 |
Instability index | 37.71 |
Isoelectric point | 7.88 |
Molecular weight | 18672.02 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP08926 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 102.92| 32| 63| 26| 57| 1 --------------------------------------------------------------------------- 26- 57 (54.71/34.73) PNPTPLDNLLAMYDLELIASSL..GRTKPDGSKG 90- 123 (48.21/29.87) PELAKIPDVITEFNPELLSAALkfDKTSINGIPG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EEAKRKRKKKQLMGVEYKRHHI 2) LDNLLAMYDLELIASSL 3) LRKSYKNHIQDLKGKHQI | 147 31 60 | 168 47 77 |
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