<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08922

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSTKPALIAADGNGPATAANGAANPASGRPLPPELAHVTNNIVPLSNILRFHTQEAYKQLSRQIELLAHTRASEPDAVRKRKLLAVLVALRQDFVKLYVLVKWAQRSKDVARLIDLLNWLRSQEFCFDNLALGLNELNHFSGAKLPQADILTALEVLVKGRPQLPSYLHLGRPPVSPQRIGQVLRDLNLALTARLALVDDMPPRFRKNYEVKDGRVVFTLAHEFRVSITVANDLVVDSAADYYRSPFFFIDFAFLFGVNSDHSLTSHDGTRAATLLPHRARARLESVVNHVLLQHSLAGLYDVLHKYATAFKLYLIARQLRVLSINSKWRGNIQYQSGSFLVIVNYWAGHFLLRGWRSFLEIGIDRNYNLHFRWFKNGRYHHDHGIRTAASTDALDALDAQYAQELNIDYVLSLVINRHSELLVRKVYDSYASAVSADTVSFLNPHQLLLKLTPKKSTVFAIDPLTGHFYFMNPSPIESAVQTKINTKPPAAKAKASVTEADLVANVVSHLVELRTDNLSKATHMRLVTMGWVANGIIKLSDYETAKLLSGLVGETSSPLHKFSFFRSRTWPPSWFLISMVSGLSSKAYWWVARLKSVKGEWVIQWVQSLDLSDTEEADHSFFKSLSRSSSNIIIHHLIVEELQRRGIGFLKLHDESVLEKFNLSHPHSHSASRTVLALHNDGNLLPIAASASTLFMACLFSGDGKLKELHTTLFGCFRNKSENYANSLLKLGVTVAVDKDQFQINSTVDLSNKLNTEDKPSNTVSMLGQVLDSLAKMNLLIKILEQVRSTDLKVTSSSFDELSFEIDPYYKPFLFCVHSEDDLSFSLRTGESEKKNVNTLVRLLNQELGQSAGALLGCFKYLKEAVILFETIDSVENQLKPASEFMLQNNFRRLHFEPKFISLNLFQFVFSLNSTHSSSPKKIQRDKIIFNVSFKKDRFAKTRKLLLKFSMKDNFNSQNLKFKKLFETIFTSSNEVQKQAMSLNQTFMKLYYDFVIDSALLKPLMDRITSAFLEFLKTPQPQ
Length1023
PositionTail
OrganismMetschnikowia bicuspidata var. bicuspidata NRRL YB-4993
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Metschnikowia.
Aromaticity0.10
Grand average of hydropathy-0.114
Instability index33.94
Isoelectric point9.42
Molecular weight115681.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08922
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.09|      17|      19|      52|      68|       1
---------------------------------------------------------------------------
   52-   68 (28.09/18.45)	HTQEAYKQLSRQIELLA
   69-   85 (27.99/18.36)	HTRASEPDAVRKRKLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.81|      14|      19|     654|     671|       2
---------------------------------------------------------------------------
  654-  671 (20.62/20.40)	HDESVLekfnLSHPHSHS
  680-  693 (24.19/12.60)	HNDGNL....LPIAASAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.55|      45|      51|     920|     965|       4
---------------------------------------------------------------------------
  920-  965 (70.30/47.35)	SPKKIQRDKIIFNVSFKKDRFA.KTRKLLLKfSMKDNFNSQNLKFKK
  973- 1018 (70.25/42.54)	SSNEVQKQAMSLNQTFMKLYYDfVIDSALLK.PLMDRITSAFLEFLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      15|      16|     211|     225|       7
---------------------------------------------------------------------------
  205-  223 (20.61/14.70)	FRknyeVKDGRVVFTLAHE
  224-  242 (19.76/13.73)	FRvsitVANDLVVDSAADY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.65|      31|      56|     555|     587|       8
---------------------------------------------------------------------------
  555-  587 (53.22/34.73)	ETSSPLHkfSFFRSRTWPPSWFLIS..MVSGLSSK
  614-  646 (47.43/25.02)	DTEEADH..SFFKSLSRSSSNIIIHhlIVEELQRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.53|      12|      18|      92|     103|      10
---------------------------------------------------------------------------
   92-  103 (21.66/14.58)	QDFVKLYVLVKW
  108-  119 (20.87/13.77)	KDVARLIDLLNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.73|      21|     329|     438|     458|      12
---------------------------------------------------------------------------
  437-  457 (34.29/19.34)	AD.TVSFLNPHQLLLKLTPKKS
  458-  479 (33.43/18.67)	TVfAIDPLTGHFYFMNPSPIES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08922 with Med14 domain of Kingdom Fungi
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