<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08919

Description Uncharacterized protein
SequenceMSRPKNRNSLLAGPGRLAAAARSSKDQLLLLRYSMDRPREPVHALANGAGPRVYPDYQPWAGPPAGAARLAAAECLHNGYLEPPAVPAESLSARTLVHETLLAPDAAAAALLGELLRTLARAYSVRNDTLNRIAGASHAPRPPPRVTMTAPRRDAWLRDLADADVPLARVAARVPHGLRHRLLLDHLCAWQVPEARAVWCVKCVLGAELLLLRRRRDPRDARGLLEWTQQVADHVARESRGPPLPGPRRLRLAYLLRLVRTLYVERLVDRACLLACVARQVRAAPAADGPALHYGVLLTALVLVQTFWRDFVRHDVLARLHAELLLWTHVEVERVPAAAGPGGGALPGALPAALRDSILGLVAGCVARLFRQRSSAFILPAAWLLVGPLLFRVLAQTTPPGAARRRLEAVFRLVDYRNESLLLNMRYSATGPRGAAPRGRPPDDTLAFIGLLDRMDLRGPLAAALRPTPPAAEPARWHTHVRLAVRWGASACRGSRPLAERVLVLCNYIKKSVLQPLTARGSATLKAEFEGELLDSIFALARVPRAALCMHSLAVLVNELCLLRIIAISAYLRKIIACGIFYISSRESELGTATQTDPHISFHLSVLANLPVLNNKQHYLILSKWTPEGEKISSNYARGMEVSRSHVLHGLLSGHFPHDFDAFLAEILLFSVGVKFLLANWLTSQIKSSISQSPKLIHLSPSAIARIYQFYVVTDNLTLFFRAFLRYVLKNEDKVIIFYLDTLHYVGHLLQHHYLLVNFLPGSSPNRISASYELFNLIISAYQDLASREPDSYDFRPLWEFINLSIDTNVAGAAASNQIKLDDPDLERYIFTKDTAESPLKVLLPAPRRNQAYSAELFVQNLNRLLAGDSLPPTADDITDYCRDIGPGNLSVPPEHFSPELDAASTLQVLLQSWYASADQLEERQDCAFSKLTKITMNAMEKRNRVFQTKAAFKSAGILDSSDCARLRRFLIKVIYHRILLFADTISMIAEATDAGGNSKLHPLASSLVFGKEVISHKLFYSESVMFTILQTQYRSTNIEELFRLAIKEMKDSLGSRDSDIWGLHSDVMKETVMQVIINHKDFAISLMFAELPAHVNAKLCCDLLQTDCDVSTIWSCTSLAPLANEFSLPVFQLLLLVLSSNEHLSXAEIGRFTLKFMDACEFAIDSSDSYFGELFNYLEWEDKAKIFNYLELYFLTHRDSLAVWESDFGSNEETNLLMFSRKNLQGVELLPVFKDFFKKFSVSSTESLEMLLDKFEQFSSLLLNILELVDNAAVLKLYSRQLHDIISVFLRLLIIHSASLTKVIAMHDSLHFVFLKNMMLLLNSTYLASGQDKLKILLFDLLFQIKGSLTQALAAPHEDDIMGSSPQVPEANAKTELSPDGATLESTNSAAIMTMSMILNLPEPEMNSYDFGTDEESSPITLDDEEINQSSDVAMANDPNLVLKLKENSVEQEDPFRPTDLKFTKQFRMESVALIEDTTTEINSGCISLSMFGAYTTKENPY
Length1503
PositionKinase
OrganismMetschnikowia bicuspidata var. bicuspidata NRRL YB-4993
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Metschnikowia.
Aromaticity0.08
Grand average of hydropathy0.021
Instability index44.51
Isoelectric point6.62
Molecular weight167361.06
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.76|      47|      47|      35|      81|       1
---------------------------------------------------------------------------
   12-   64 (77.87/45.59)	AG..PG........RLAAAARSSKDQL...........lllrysMD.......RPREPVHALANGAGPRVYP.DYQPWA..GPP
   65-  105 (53.77/28.82)	AG..AA........RLAAAECLHNGYL...............epPA.......VPAE...SLS..ARTLV....HETLL..APD
  106-  175 (51.82/27.46)	AA..AAallgellrTLARAYSVRNDTLnriagashaprppprvtMT.......APRRDA.WLRDLADADV.P.LARVAA..RVP
  343-  400 (54.31/29.20)	GGalPG........ALPAALRDSILGL.................VAgcvarlfRQRSSAFILPA.AWLLVGPlLFRVLAqtTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.51|      45|      49|     242|     290|       2
---------------------------------------------------------------------------
  206-  240 (29.46/16.19)	GAELL....LLRRR.............................RD......P.....R..DARGLLEwtqqvadHVARESR........
  246-  290 (80.42/36.02)	GPRRLRLAYLLRLV.............................RTL...YVE.....RLVDRACLLA.......CVARQVRAAPAADGP
  303-  341 (31.35/ 7.92)	............LV.............................QTFwrdFVRhdvlaRL..HAELLL.......WTHVEVERVPAAAGP
  401-  474 (56.29/22.20)	GAARRRLEAVFRLVdyrneslllnmrysatgprgaaprgrppdDTL...AFI.....GLLDRMDLRG.......PLAAALRPTPPAAEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.78|      14|      15|    1229|    1242|       3
---------------------------------------------------------------------------
 1229- 1242 (25.37/13.89)	ELLPVFKDFFKKFS
 1247- 1260 (24.42/13.12)	ESLEMLLDKFEQFS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.54|      47|      56|     598|     647|       4
---------------------------------------------------------------------------
  598-  647 (70.36/72.59)	PHiSFHlSVLANLPVLNNKQHYLiLSKWTPEGEKIS.SNYARGMEVSRSHV
  657-  704 (75.18/60.37)	PH.DFD.AFLAEILLFSVGVKFL.LANWLTSQIKSSiSQSPKLIHLSPSAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      21|      56|     489|     533|       5
---------------------------------------------------------------------------
  489-  511 (33.05/60.07)	ASACRGSrpLAERVLVLC........NYIKK
  546-  574 (31.04/ 6.92)	AALCMHS..LAVLVNELCllriiaisAYLRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.99|      14|      15|     715|     728|       6
---------------------------------------------------------------------------
  715-  728 (24.75/13.57)	DNLTLFFRAFLRYV
  733-  746 (24.24/13.14)	DKVIIFYLDTLHYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.59|      38|     600|     803|     840|       8
---------------------------------------------------------------------------
  803-  840 (63.97/36.95)	NLSIDTNVAGAAASNQI.......KLDDPDLERYIFTKDTAESPL
 1377- 1421 (59.62/33.96)	ELSPDGATLESTNSAAImtmsmilNLPEPEMNSYDFGTDEESSPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.83|      42|      49|    1017|    1061|      12
---------------------------------------------------------------------------
 1017- 1061 (61.14/52.20)	HKLFYSESVMFTILqtQYRSTNIEELF.....RLAIKEMKDSLGSrDSDI
 1065- 1111 (68.69/46.64)	HSDVMKETVMQVII..NHKDFAISLMFaelpaHVNAKLCCDLLQT.DCDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.93|      18|      25|     853|     876|      15
---------------------------------------------------------------------------
  866-  887 (25.58/22.12)	LAGDSLPPTADditdYCRDIGP
  892-  909 (29.36/ 7.61)	VPPEHFSPELD....AASTLQV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08919 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) LMNDMVHKWLRQDNADDDAKKQTG
2) NGPRLGELG
87
123
110
131