Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MFIEQRLEALNKIDEGIVQLLESLGCIFETYTVPSKSDFQDVSQIRDHFSGDVRKFYSSLSNVAISLRKEVKLLDDNTGTSQLNKDLVMVLPVSVEKKNTALGEIKLEAELKNLE |
Length | 115 |
Position | Head |
Organism | Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Metschnikowia. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.204 |
Instability index | 29.46 |
Isoelectric point | 4.93 |
Molecular weight | 12976.69 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP08916 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) QLNKDLVMVLPVSVE 2) VSQIRDHFSGDVRKFYSSLSNVAISLRKEVKLLDDNT | 82 42 | 96 78 |
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