<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08915

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPVADSTAAVATHYYKVARLQLVSYSIYTTTDAAPDQVLLELELRIRHDHPRVLVTYNNKCLYHFRLGHWPAANDCPGSSHNTPGSGHNNPGSNNTPGSGHNNPGSGHNNPGSNNTNDPAGPADLPARYPQLTRKHHAVVSAEQLASPAAGPRPRSGTPAGAPAADEHLPYASLLFAKAVKKLLVYNVAAGGQMHMFGNHVAARTAPGLAQYRVVQMDPVLLAGGELWVLVTQRARLPLFDLGVVSLDHVTPGFAACFAIYVVPAGLRCHLYDPHNVRRSFTATPPRSAPTLMRLLKASTGVELAAKPRVVWAKLVPNLQHLNSHTSPVARFVHDVDNRKYILWPWELCMLQFGSADVPPRQTARPPPDPMALLDAYWAHALSAPGPGPPAAGSTPTRGLATAALAPVETGDPFSVPSGASGAQPGVLSAGHAMLPLVFLGHVSAAAPFGDAPDLAFPFVPSDGGKNDIDIDIDNKNDIDIVNDNDNDNDANDNKNDNKNDNDNKIENNTNTNTNTNANDNKNDIKNDNDIGNSGSDDDLFGASSDLDARELPDGSAGSAPPGEPLPASQNTPPRASASPMRAKEDSPRPAGSAAYLGIPRNEMIHADIRQFTPGSYDDPGAPPPLVPTPAVAQHGVFGGFPGLLPLHAPQNTHLQPPASAHRLARRDRRHLDSAAAWAFSPIVFNPKIKNSIDTKYGKGGKFYVDTEESSGPELEPRRPRLRETSVLAYDLNVLKDSAAHLPTRVSDSSLSAAEGKDGDTATGRRPATAANLPPELASNVDLDMLSAESDHDVDSDDDNDDGADDDEIESDEDEDDSTRLPFSDLNGATLKLNTHVGDLFDTAPSQDAMQDPHPPPELAVSAHFPFSGANSVLISPGTAQINPSRTNKDSSPFGLGIDTHAVSLSPLPVSDMKPDVNPGVASEPLDPLPSNKDILVPEASNTPSSSSSTSSGVSESSNCLPLILRSINTQSIPNMFLLNKVPGAWGTVSMAGGFDMDADDEEDDIEHKDAGLSVKVKHMDELLNWLMPNLVFDLGLTDFERHTQLRLPDFFSEEVLTGLTDSSASQETARIFKETFPQSHVVTLNELLVTPSTSSSAVSLPALDSKAPLPFLDEMTMDMNEGSLNFASPSADASLLYWDSFIPNASIGSGVSGSEKRRTGKFDEKSVVVFDEVKVQVCKNQKDIINLNILGTRFWKYFNFSPINGPKKFQVLMLTENHLRHDKHFSNTCGDAEFLDMLKYNYMDMRLGSVKTLNLQTFETRPDLEGISNGILMIDKDLGDRSYNDFYKRANRKLKNLAELIKLDLINRTNRFEFDRPLLLLFIDFGESINSVLQIAKICRNFKVNLNNHQLSLVEVFAHVIPSSHLFKKSSSGCYLKYLSDSKLAKISTTIYNKCPNTHLVDLKLPVLDREEPRKLYSQLVKDTPTSINFKFLSRLGKESLNSDGQDDMFLHVAYERSVDKNWICAAWSDPLGIVTHMRSWYCPPSAKAGSDKDVHDLGSIIFKIWEISNNLFKKLNEDILQRICGSSKKKFLVLARVSSIIPDDELLHWKRLTAKYKDISLIVLTTNRLPKYLFKSASSNGHSMFDETHNETKIVLEAQGNVSENTEKKSFKSEGSDFIQSFDAFPATHSSTSPLGGIAMSASPMNNALTFHSPQQFLNAPSSIYLPPDGRLESMPNDADCTLKDTSFDIVGVIPRVALPSCNSPTRYSMRTGYLVKESLALKNLVEKEYVVFEFSLLSCSNYWNLDNAMKITLKQFKKLVMLNDILGVYDRAAVSMDDSRKARQAELQTLVPWHINAVVKALDYLVHVHVEE
Length1815
PositionKinase
OrganismMetschnikowia bicuspidata var. bicuspidata NRRL YB-4993
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Metschnikowia.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index41.00
Isoelectric point5.56
Molecular weight198153.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08915
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.25|      17|      18|      77|      94|       1
---------------------------------------------------------------------------
   68-   86 (29.50/12.22)	GH.WPAANdcPGSSHNTPGS
   87-  106 (27.75/15.18)	GHnNPGSNntPGSGHNNPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.23|      19|      20|     483|     502|       2
---------------------------------------------------------------------------
  484-  502 (38.71/19.98)	DNDNDNDANDNKNDNKND..N
  503-  523 (27.52/13.37)	DNKIENNTNTNTNTNANDnkN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     815.03|     188|     196|     649|     842|       3
---------------------------------------------------------------------------
  360-  554 (187.02/101.59)	.PRQT.ARPP.PDPMAL.........LDAYWAHALSA..PGPGPPAAGSTPTR.GlataalapveTGDPFSVPSG.ASGAQ..........P...................GVLSAGHAMLPlVFLGHVSAAAPFGDAPDLAFPFVPSDGGknDIDID.IDNKND..IDIVN.....dndndndandnkndnkndndnkienntntntntnandnknDIKNDNDiGNSGS...........DD.......D..LFGASSDLDAR..ELPD
  568-  648 (76.81/35.11)	ASQNT...PPrASASPMrAKEDsPRPAGSA...AYLG..IPRNEMIHADI.RQFT..........PGS..YDD..PGAPPPLVP............TPA.......VA.QHGVFGGFPGLLP.LH.................................................................................................................................................
  650-  842 (296.52/181.62)	.PQNTHLQPP.ASAHRL.ARRD.RRHLDSAAAWAFSP..IVFNPKIKNSIDTKYG..........KGGKFYVDTEESSGPELEP.....RRPRLrETSV.......LAYDLNVLKDSAAHLP.TRVSDSSLSAAEGKDGDTATGRRPATAA..NLPPE.LASNVD..LDMLSAESDH........................................DVDSDDD.NDDGAdddeIEsDEDEDDSTRLPFSD..LNGATLKLNTHVGDLFD
  844- 1039 (254.67/141.67)	APSQDAMQDP.HPPPEL.AVSA.HFPFSGANSVLISPgtAQINPSRTNKDSSPFG..........LG....IDTHAVS...LSPlpvsdMKPDV.NPGVasepldpLPSNKDILVPEASNTP.SSSSSTSSGVSESSNCLPLILRSINTQS...IPNMfLLNKVPgaWGTVSMAGGF........................................DMDADDE.EDD......IE.HKDAGLSVKVKHMDelLNWLMPNLVFDLG.LTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.91|      32|      32|     190|     221|       4
---------------------------------------------------------------------------
  190-  221 (58.75/33.67)	AGGQMHMFGNH........VAARTAPGLAQYRVVQMDPVL
  223-  251 (48.13/26.18)	AGGELWVL...........VTQRARLPLFDLGVVSLDHVT
  265-  292 (22.04/ 7.78)	AGLRCHLYDPHnvrrsftaTPPRSAPTL............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.91|      43|      51|    1337|    1387|       5
---------------------------------------------------------------------------
 1343- 1387 (68.31/63.06)	FKVNLNNHQLSL.VEVFAHVIPS...SHLFKKSSSGCYLKYLsdSKLAK
 1393- 1439 (65.60/39.29)	YNKCPNTHLVDLkLPVLDREEPRklySQLVKDTPTSINFKFL..SRLGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.15|      30|      32|    1058|    1087|       7
---------------------------------------------------------------------------
 1058- 1087 (48.52/28.40)	TGLTDSSASQETARIFKETF.P..QSHVVTLNE
 1091- 1122 (43.74/24.78)	TPSTSSSAVSLPALDSKAPL.PflDEMTMDMNE
 1125- 1148 (20.88/ 7.51)	..LNFASPSADASLLYWDSFiP..NASI.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08915 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANDCPGSSHNTPGSGHNNPGSNNTPGSGHNNPGSGHNNPGSNNTNDPAGPADLPARYPQLTRKHHAVVSAEQLASPAAGPRPRSGTPAGAPA
2) DAPDLAFPFVPSDGGKNDIDIDIDNKNDIDIVNDNDNDNDANDNKNDNKNDNDNKIENNTNTNTNTNANDNKNDIKNDNDIGNSGSDDDLFGASSDLDARELPDGSAGSAPPGEPLPASQNTPPRASASPMRAKEDSPRPAGSAAYLGIP
3) HLPTRVSDSSLSAAEGKDGDTATGRRPATAANLPPELASNVDLDMLSAESDHDVDSDDDNDDGADDDEIESDEDEDDSTRLPFSDLNGA
4) LSPLPVSDMKPDVNPGVASEPLDPLPSNKDILVPEASNTPSSSSSTSSG
5) NTHVGDLFDTAPSQDAMQDPHPPPELAVSAHFPF
6) PGPGPPAAGSTPTRGLATAALAPVETGDPFSVPSGASGA
7) SVLISPGTAQINPSRTNKDSSPFGLGIDTH
73
451
741
905
834
385
872
164
600
829
953
867
423
901










Molecular Recognition Features






MoRF SequenceStartStop




NANANA