<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08908
Description |
Mediator of RNA polymerase II transcription subunit 5 (Fragment) |
Sequence | MSSTTLLKKLLRASLARNTNPKLFASLLEQLLAREQISDAELGEMLLNVADSPVKANSTTSILARRLQIEYVLEFAFSSSENLARFFKLLPQLSLKSQLKYILYFKTQVGKIIDRSLINEFYNGLAQFTIAASPSRPGECSPHSNRLWYHVVFVWGAFIDLDSSIPANPSLKESFQKMALFAGDLEDDYIGALISRKFGAAADPGASLNFQTTRMAKSEEAPTTMPEKSLSLNLNGKKYSNYVSLKKFIWLNFHFQLWKMDTEMSRAFMTFFNLQDLSHTDLAKELICSFLNGAAVAVRLGEEPYVIFNWKNFILTHLAQDLKEIVLSSHAVDHEWHETVSAAITSCNDLVITETKIGGVKESYNLNKEFMRSCLHQELISLEKYIQVFPSEAENLSTSILAHEIENLRLTELITAEFKSRLENVNPEFTSLQESNLIDYFKNLPLTNFRFLNAKQCKLAQLSENLIDNIVREKNNEKLRWISLVFLNVPSIANFIFYQSRKGPWMFLSKIINYIDSESFNVDEDDGNFQDTYACFGVILTSVISVAAFFGIEFASLGLKNSYTIDYINQFYFRLCNMLTNTYTGASEQEKQIISNYENLVTEWANALFDVNNDGLSDDLLKSVNVKQIYK |
Length | 631 |
Position | Tail |
Organism | Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Metschnikowiaceae> Metschnikowia.
|
Aromaticity | 0.12 |
Grand average of hydropathy | -0.094 |
Instability index | 40.17 |
Isoelectric point | 5.51 |
Molecular weight | 71876.23 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP08908
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.31| 12| 26| 346| 357| 1
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346- 357 (20.95/12.71) SC..NDLVITETKI
373- 386 (16.36/ 8.52) SClhQELISLEKYI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.56| 24| 34| 156| 179| 2
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156- 179 (42.35/30.65) GAFIDLDSSIPANPSLKESFQ..KMA
191- 216 (37.21/26.03) GALISRKFGAAADPGASLNFQttRMA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 118.71| 39| 55| 401| 440| 3
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401- 440 (58.40/44.20) LAHEIENLrLTELITAEFKSRLENVNPEFTSLQE.SNLIDY
459- 498 (60.31/40.69) LAQLSENL.IDNIVREKNNEKLRWISLVFLNVPSiANFIFY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.08| 13| 16| 6| 20| 4
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6- 18 (20.35/17.30) LLKKLLRASLARN
23- 35 (20.73/ 8.88) LFASLLEQLLARE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.26| 27| 161| 101| 155| 6
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115- 155 (36.29/75.41) RSLINEFYNGlaqftiAASPSRPGEcSPHsnrlwyhVVFVW
284- 310 (51.97/24.85) KELICSFLNG......AAVAVRLGE.EPY.......VIFNW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 33.49| 10| 17| 56| 65| 7
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56- 65 (16.54/12.85) ANSTTSILAR
76- 85 (16.95/13.41) AFSSSENLAR
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