<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08879

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGGFLLGFGSEVLESRRQPQLAPYKLKCEKEPLNSRLGPPDFYPQTPTCPEETLTREYLQSGYKESVEGIEEVREIILSQVGYFIKPEVTLRCKEAIRKRFRAINESRAQKRKVDTSIVLSSRQLIYNAGQVYGVPLSGSLLIKPGVFPEQRPCGEDFRRKWIEALSQQHKRLRSLSEHVPHGYRRKSLFDVLIRHNVPLLRATWFIKVSYLNQVRPASTSVSSGAPDKAQATRTEQWTKDITDYLQQLLDEFLSKDGSAVPLSGRDQSSPGLMGQPPSAKHRAESSPVISEVEDTSFLFRWWYVVRLLQWHFAEGLVLPSLVIEWVFAQLQEKDSVDALELLLPIVLSMIESISLSQTYARTFVEITIRNLSDLSSGNLSLISSSKKTSVASTLVEMLRYMILSVPDTFVSLDCFPLPSHVAPDIYGRSNIEAVHFETRDAYVRYLSCGHAVSCIQRRASNLGKIVSPNLQGSSAAKVVQTLDKALTMGSMTLAYSSLFEDLSDPAMEERWIAEVSPCLRASLMWIGTIELSLICSIFFLCEWATCDYRDTRTTPSQNVKFTGRKDFSQIYVAVLLLKNKVQEMHSQLTSKNSAPLVIRNSGRSASLNDTSLQAAVVENPSFIRSCTKILDEKRINKKDIFQSPGPFHDIIVCWLDQHEICDSGGLKRVEVLILELIRSGIFHPQVYVRQLIVSGIMDRNDTQLDLERKRRHHKILKQLPASCLFDILEEARIAEAQLLHEVVAVYSTERRLVLRELSDGQSNYVSNRSERNSSGQKQNDHQAGTRDVKHGRTKEQVAQVKTLISNLLRFPYSSSLPIEARSDESKGSVKRPINSSDIKVDFAEGRPGCEECKGSKRQKLDERSSFQGILLNQSDDEDSWWVRKGPKFPESFKVEPPQKTTKQSSRGRQKIVRKTQSLAQLAAARIESSQGASTSHVCDNKVSCPHHKSVGEGEISKDFERGKVQSPVDVGKAIKRLRMVEKRSVALWLLKSVRQLVEGNEKAASKASVTSVFSASTDDRNAVRWRLGEDELLSVLYIFDICCDFVSAVRFLIWLLAKTLSGVSNPTQVGRNIMLPKNRESLICHVGEAFLLSSLQRYENVLVATDLLPEALTAIMPKSTNMIVGRVYGSVAFSYGRNLLKKYKDLVSVVRWEKNYRASGDQKLLAELDAGRSVDGDSVFSSGASAGGEEIDEHIRQKLSGRMPRTVTNMKEIVQRHVEEALHHFYGKERKNIATAPRTPPEKWEDSYQIAHDIVMGLLDCIRQNAGATPDGDPSVVASAVAAIVGNVGLAVAKLPDFSCSNYQNLPSSIKNSLNCARHILSIHIVSLCLLKEALGERYSRIIEIALAVEASSAVSVAFAPPRGHRSQFQVSPEAHDIYGNHSSEVLNNSQKGFGGRATKAAAAVSALVVGALIHGIISLERMIVVFKLKEGLDILQFMRNARSSSNGMSRSVGTFKPENCIELYVHWFRLLVGNCRTVLDGLVGEILGESYILALSRIQRMLPLSLVFPPAYAIFGMVIWRPYILNSNVIMREDIPVYQYLSLAIGEAIRHQPFRDVCFRNSYTFYDLLANDIGDSEFAAMLELQSPDKHLKTMAFIPLRARLFLNALIDCKMPASTIMKEDGSWVSESGELRSNTESEAKLLERLLQILDTLQPAKFHWQWVELRLLLNEQALVEKIETQNMSFVDAIRSLSPNAENFALTESEKRFTEIVLSRILVRPDAAPLYSEVVHLIGKLLQESLVMDTKWFLAGHDVLLGRKSIRQQLLFVAQRKGLPTKAQFWKPWGWSSLGEAVANRGEKRKLEAIAIEEGEVVDECIDHKKLGKMNSQTVDSEGVGSIYQHITEKAFAELILPCIDRSSSELRNLFATELIKQMGVIEQHISTITRNGMKQAGVASVGVEGTSNKANSRKGMRGGGSPVLGRRPTAVSDSVPPSAVALRASLSLRLQFLIRLLPVIFADREPSARNMRQALASIILRLLGSRVVYEDADLSLPPPNPSALKWDAESSMDACVTSLFDRPGESLFERLLSIFHALLSSCKPSWLKPKSAPKSTVKSPRDFPAFDREAAESIQMLQSDLDRMELPLTIKRRIQSAMPFLPPSLPSSIPCHPPILPPSALSPLQSTMLAPAPQQRTAQASRVPTNLSGRSKALPSLDPDMEIDPWTLLEDGTVSASTSSSGGNGSMGGVSVDHANFKACSWLKGAIRVRRTDLTYTGALDDDS
Length2222
PositionKinase
OrganismAnanas comosus (Pineapple) (Ananas ananas)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Bromeliaceae> Bromelioideae> Ananas.
Aromaticity0.07
Grand average of hydropathy-0.208
Instability index54.04
Isoelectric point8.83
Molecular weight247441.03
Publications
PubMed=27374615

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08879
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.77|      52|     123|    1234|    1290|       1
---------------------------------------------------------------------------
 1152- 1187 (39.42/19.24)	..........RWEKNYRA...SGDqKLLAELD.....AGRSVDGD.SVFSSGASA......
 1234- 1290 (83.28/67.80)	IATAprtPPEKWEDSYQI...AHD.IVMGLLDCIRQNAGATPDGDPSVVASAVAAIVgnVG
 1358- 1412 (80.06/50.51)	VAFA...PPRGHRSQFQVspeAHD.IYGNHSSEVLNNSQKGFGGRATKAAAAVSALV..VG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.96|      41|     123|     831|     872|       2
---------------------------------------------------------------------------
  831-  872 (67.10/50.25)	KRPINSSDIKVDFAEGR...PgCEECKGSKRQKLDERSSFQGILL
  948-  991 (63.85/42.39)	HKSVGEGEISKDFERGKvqsP.VDVGKAIKRLRMVEKRSVALWLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.32|      23|     123|     135|     159|       3
---------------------------------------------------------------------------
  135-  159 (39.33/25.09)	VPLSGSLLIKPGVFPEqrPCGEDFR
  261-  283 (43.99/22.49)	VPLSGRDQSSPGLMGQ..PPSAKHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.99|      35|     123|     399|     481|       5
---------------------------------------------------------------------------
  356-  390 (55.21/100.93)	LSQTYARTFVEITIRNLSDLSSGNLSLISSSKKTS
  447-  481 (58.78/18.63)	LSCGHAVSCIQRRASNLGKIVSPNLQGSSAAKVVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.96|      27|      87|    1113|    1139|       9
---------------------------------------------------------------------------
 1113- 1139 (49.66/31.52)	LTAIMPKS.TNM..IVGR.VYGSVAFSYGRN
 1200- 1230 (37.31/21.88)	LSGRMPRTvTNMkeIVQRhVEEALHHFYGKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.59|      47|     103|    1953|    2002|      14
---------------------------------------------------------------------------
 1953- 2002 (70.60/45.01)	RLLPVIfaDRE..PSARNMRQALASIILRLLGSRVVyEDADLSLPPPNPSAL
 2059- 2107 (78.98/40.63)	RDFPAF..DREaaESIQMLQSDLDRMELPLTIKRRI.QSAMPFLPPSLPSSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08879 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASVGVEGTSNKANSRKGMRGGGSPVLGRRPTA
2) NYVSNRSERNSSGQKQNDHQAGTRDVKHGRTKE
3) SPLQSTMLAPAPQQRTAQASRVPTNLSGRSKALPS
1897
764
2120
1928
796
2154










Molecular Recognition Features






MoRF SequenceStartStop




1) SWWVRKG
880
886