<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08879

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGGFLLGFGSEVLESRRQPQLAPYKLKCEKEPLNSRLGPPDFYPQTPTCPEETLTREYLQSGYKESVEGIEEVREIILSQVGYFIKPEVTLRCKEAIRKRFRAINESRAQKRKVDTSIVLSSRQLIYNAGQVYGVPLSGSLLIKPGVFPEQRPCGEDFRRKWIEALSQQHKRLRSLSEHVPHGYRRKSLFDVLIRHNVPLLRATWFIKVSYLNQVRPASTSVSSGAPDKAQATRTEQWTKDITDYLQQLLDEFLSKDGSAVPLSGRDQSSPGLMGQPPSAKHRAESSPVISEVEDTSFLFRWWYVVRLLQWHFAEGLVLPSLVIEWVFAQLQEKDSVDALELLLPIVLSMIESISLSQTYARTFVEITIRNLSDLSSGNLSLISSSKKTSVASTLVEMLRYMILSVPDTFVSLDCFPLPSHVAPDIYGRSNIEAVHFETRDAYVRYLSCGHAVSCIQRRASNLGKIVSPNLQGSSAAKVVQTLDKALTMGSMTLAYSSLFEDLSDPAMEERWIAEVSPCLRASLMWIGTIELSLICSIFFLCEWATCDYRDTRTTPSQNVKFTGRKDFSQIYVAVLLLKNKVQEMHSQLTSKNSAPLVIRNSGRSASLNDTSLQAAVVENPSFIRSCTKILDEKRINKKDIFQSPGPFHDIIVCWLDQHEICDSGGLKRVEVLILELIRSGIFHPQVYVRQLIVSGIMDRNDTQLDLERKRRHHKILKQLPASCLFDILEEARIAEAQLLHEVVAVYSTERRLVLRELSDGQSNYVSNRSERNSSGQKQNDHQAGTRDVKHGRTKEQVAQVKTLISNLLRFPYSSSLPIEARSDESKGSVKRPINSSDIKVDFAEGRPGCEECKGSKRQKLDERSSFQGILLNQSDDEDSWWVRKGPKFPESFKVEPPQKTTKQSSRGRQKIVRKTQSLAQLAAARIESSQGASTSHVCDNKVSCPHHKSVGEGEISKDFERGKVQSPVDVGKAIKRLRMVEKRSVALWLLKSVRQLVEGNEKAASKASVTSVFSASTDDRNAVRWRLGEDELLSVLYIFDICCDFVSAVRFLIWLLAKTLSGVSNPTQVGRNIMLPKNRESLICHVGEAFLLSSLQRYENVLVATDLLPEALTAIMPKSTNMIVGRVYGSVAFSYGRNLLKKYKDLVSVVRWEKNYRASGDQKLLAELDAGRSVDGDSVFSSGASAGGEEIDEHIRQKLSGRMPRTVTNMKEIVQRHVEEALHHFYGKERKNIATAPRTPPEKWEDSYQIAHDIVMGLLDCIRQNAGATPDGDPSVVASAVAAIVGNVGLAVAKLPDFSCSNYQNLPSSIKNSLNCARHILSIHIVSLCLLKEALGERYSRIIEIALAVEASSAVSVAFAPPRGHRSQFQVSPEAHDIYGNHSSEVLNNSQKGFGGRATKAAAAVSALVVGALIHGIISLERMIVVFKLKEGLDILQFMRNARSSSNGMSRSVGTFKPENCIELYVHWFRLLVGNCRTVLDGLVGEILGESYILALSRIQRMLPLSLVFPPAYAIFGMVIWRPYILNSNVIMREDIPVYQYLSLAIGEAIRHQPFRDVCFRNSYTFYDLLANDIGDSEFAAMLELQSPDKHLKTMAFIPLRARLFLNALIDCKMPASTIMKEDGSWVSESGELRSNTESEAKLLERLLQILDTLQPAKFHWQWVELRLLLNEQALVEKIETQNMSFVDAIRSLSPNAENFALTESEKRFTEIVLSRILVRPDAAPLYSEVVHLIGKLLQESLVMDTKWFLAGHDVLLGRKSIRQQLLFVAQRKGLPTKAQFWKPWGWSSLGEAVANRGEKRKLEAIAIEEGEVVDECIDHKKLGKMNSQTVDSEGVGSIYQHITEKAFAELILPCIDRSSSELRNLFATELIKQMGVIEQHISTITRNGMKQAGVASVGVEGTSNKANSRKGMRGGGSPVLGRRPTAVSDSVPPSAVALRASLSLRLQFLIRLLPVIFADREPSARNMRQALASIILRLLGSRVVYEDADLSLPPPNPSALKWDAESSMDACVTSLFDRPGESLFERLLSIFHALLSSCKPSWLKPKSAPKSTVKSPRDFPAFDREAAESIQMLQSDLDRMELPLTIKRRIQSAMPFLPPSLPSSIPCHPPILPPSALSPLQSTMLAPAPQQRTAQASRVPTNLSGRSKALPSLDPDMEIDPWTLLEDGTVSASTSSSGGNGSMGGVSVDHANFKACSWLKGAIRVRRTDLTYTGALDDDS
Length2222
PositionKinase
OrganismAnanas comosus (Pineapple) (Ananas ananas)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Bromeliaceae> Bromelioideae> Ananas.
Aromaticity0.07
Grand average of hydropathy-0.208
Instability index54.04
Isoelectric point8.83
Molecular weight247441.03
Publications
PubMed=27374615

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08879
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.77|      52|     123|    1234|    1290|       1
---------------------------------------------------------------------------
 1152- 1187 (39.42/19.24)	..........RWEKNYRA...SGDqKLLAELD.....AGRSVDGD.SVFSSGASA......
 1234- 1290 (83.28/67.80)	IATAprtPPEKWEDSYQI...AHD.IVMGLLDCIRQNAGATPDGDPSVVASAVAAIVgnVG
 1358- 1412 (80.06/50.51)	VAFA...PPRGHRSQFQVspeAHD.IYGNHSSEVLNNSQKGFGGRATKAAAAVSALV..VG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.96|      41|     123|     831|     872|       2
---------------------------------------------------------------------------
  831-  872 (67.10/50.25)	KRPINSSDIKVDFAEGR...PgCEECKGSKRQKLDERSSFQGILL
  948-  991 (63.85/42.39)	HKSVGEGEISKDFERGKvqsP.VDVGKAIKRLRMVEKRSVALWLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.32|      23|     123|     135|     159|       3
---------------------------------------------------------------------------
  135-  159 (39.33/25.09)	VPLSGSLLIKPGVFPEqrPCGEDFR
  261-  283 (43.99/22.49)	VPLSGRDQSSPGLMGQ..PPSAKHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.99|      35|     123|     399|     481|       5
---------------------------------------------------------------------------
  356-  390 (55.21/100.93)	LSQTYARTFVEITIRNLSDLSSGNLSLISSSKKTS
  447-  481 (58.78/18.63)	LSCGHAVSCIQRRASNLGKIVSPNLQGSSAAKVVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.96|      27|      87|    1113|    1139|       9
---------------------------------------------------------------------------
 1113- 1139 (49.66/31.52)	LTAIMPKS.TNM..IVGR.VYGSVAFSYGRN
 1200- 1230 (37.31/21.88)	LSGRMPRTvTNMkeIVQRhVEEALHHFYGKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.59|      47|     103|    1953|    2002|      14
---------------------------------------------------------------------------
 1953- 2002 (70.60/45.01)	RLLPVIfaDRE..PSARNMRQALASIILRLLGSRVVyEDADLSLPPPNPSAL
 2059- 2107 (78.98/40.63)	RDFPAF..DREaaESIQMLQSDLDRMELPLTIKRRI.QSAMPFLPPSLPSSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08879 with Med12 domain of Kingdom Viridiplantae
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