<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08856

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDGDAAAAAANATADADAGRDAGGDWRSKIRPDGRAKIVDQIIGKLKMHTQNSVPEALRAIASKVEEKHFTTATSQGQPLAVPKVEHSPENTPLTPQNFRKITDSLTVHGTSFSPNCNMRCAPVVLRNSPNRSLGQDEVPNSNTVQRQVQNSHFYANHTRQLPMQNSRHQSLLQSNMQQQPPREHFSLLPNQFQSPHQSFMDSNFNLRQNQVRQVIPSSIHEHLQSTSVGRQHHAPLNFGQLRSSSVRRQSISTPQKSIMPSREQLIGQRSNISNMQQRQLLGQQNGVLIFSDIHKNCQNSADNLGVTNAVPQLQTHQPSLMLLESQSQKTRHQPSQQQLYSDIQTMMQLQRESAMHQQPDSLKQETDDPQSSDSVLRPQNIIEDNKQSIPSNAETLVASSSSPVDTATQMESATQLDWQEDLYQKINFLKEAILLREGINEISYISLIPLKRRLFMVVLRLEIQSMKEMYFGELKHLHQKFSLLIQQNQHTPMLHFPKGDSSFYAPSTLKETEKTSGTSAVPSVANCRHNLTTVASQQTQPNGVTTLGGISSSPLLSNFSSSEENKPSVIDDTNGPEKPINRLIKSVQSMSPEVLHSVVDDILGVGNLTGRIAGSAPGCISRPRPSLGKNLAVITKRHLQDQQFSSQQRKKMKRDITSVASSFVSSTGRKSDGLDESYSVVTSESESAASTCSKRRKIAAGHALVDEIREINRLLIDTVLSISNEDKDFNDAASKGHEGTIIKLSFSAVSISPSLKSHLASSQPSLIMPLRLLVPANYPKCSPIVLDNPLGEESIKSGDLSTRMQSRFSMYLCCLSQPMSLRAIAKGWDACARKVIEEYALQNGGAYLEPLGDIAPVSGGEDDGVDFELPPVDELCLPGREPLDRGHHLYLAGSNLAQRAGVEHRRPPLRVLELERAGRGPLQSEFLDVSEHQPRQEKQNLVDEPQWQPFQEEYRHFERRFAEHFSREHVNLLRKHSLERFLKTYGVADDHRGECVVVAEVEADLHAGVAAADDEHALPRVLLAGLVVGDVRDAAAEFGVEPRDLGHDALRVLAGGDDEPPPDVLDLGAAGPGLGGPHAPEAAGAVEAGRLHGLVEARVDVIKNGVRYYVIDELLLGRVVGVVVGEGEARQLAELLGQVQLEAVVGAVLPEGGHAVCPLQDDERHALLLQAGRHRQPRRPRADDNRPVHPHAPPRRRRQHELIPLPHPDHYS
Length1213
PositionTail
OrganismAnanas comosus (Pineapple) (Ananas ananas)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Bromeliaceae> Bromelioideae> Ananas.
Aromaticity0.04
Grand average of hydropathy-0.535
Instability index56.00
Isoelectric point6.41
Molecular weight133777.84
Publications
PubMed=27374615

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08856
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      14|      15|    1178|    1192|       1
---------------------------------------------------------------------------
 1178- 1192 (24.95/15.08)	PRRPRADDNRPVhPH
 1195- 1208 (28.73/12.96)	PRRRRQHELIPL.PH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.01|      20|      22|    1106|    1127|       2
---------------------------------------------------------------------------
 1105- 1126 (29.26/23.29)	NGVRYYVIDelLLGR.....VVGVVVG
 1127- 1151 (26.75/14.75)	EGEARQLAE..LLGQvqleaVVGAVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.96|      18|      22|     267|     288|       3
---------------------------------------------------------------------------
  271-  288 (32.49/28.53)	SNI.SNMQQR.QLLGQQNGV
  292-  311 (23.47/ 8.22)	SDIhKNCQNSaDNLGVTNAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.68|      15|      22|    1045|    1061|       5
---------------------------------------------------------------------------
 1045- 1061 (22.60/17.84)	DLGhdALRVLAGGDDEP
 1067- 1081 (30.09/16.39)	DLG..AAGPGLGGPHAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.48|      10|      15|     223|     232|       6
---------------------------------------------------------------------------
  223-  232 (18.69/ 9.96)	HLQSTSVGRQ
  241-  250 (17.78/ 9.11)	QLRSSSVRRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.97|      27|      27|     157|     183|       7
---------------------------------------------------------------------------
  157-  183 (52.30/26.39)	NHTRQLPMQ.N...SRHQSLLQ....SN..MQQQPPR
  184-  213 (37.84/17.11)	EHFSLLPNQfQ...SPHQSFMD....SNfnLRQNQVR
  312-  332 (24.15/ 8.32)	......PQL.Q...THQPSLML....LE..SQSQKTR
  333-  360 (22.67/ 7.37)	HQ....PSQ.QqlySDIQTMMQlqreSA..MHQQP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.43|      21|      24|      76|      96|       8
---------------------------------------------------------------------------
   55-   72 (19.90/ 8.62)	...PEALRAIASKVE.EKHFTT
   76-   96 (36.60/22.73)	QGQPLAVPKVEHSPE.NTPLTP
  102-  123 (30.93/17.94)	ITDSLTVHGTSFSPNcNMRCAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.71|      24|      28|     550|     576|      11
---------------------------------------------------------------------------
  553-  576 (42.13/35.02)	SSP...LLSNFSS.SEENKPSVIDDTNG
  578-  605 (31.58/15.54)	EKPinrLIKSVQSmSPEVLHSVVDDILG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.52|      16|      28|     881|     908|      12
---------------------------------------------------------------------------
  881-  908 (14.60/28.62)	REPLDRGhhlYLAGSnlaqragvEHRrP
  920-  935 (30.92/13.66)	RGPLQSE...FLDVS........EHQ.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.45|      18|      28|     787|     804|      13
---------------------------------------------------------------------------
  787-  804 (30.45/16.26)	LDNPLGEESIKSG.DLSTR
  816-  834 (27.00/13.65)	LSQPMSLRAIAKGwDACAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.37|      19|      28|     937|     955|      14
---------------------------------------------------------------------------
  937-  955 (35.47/24.11)	QEKQNLVDEPQWQPFQEEY
  968-  986 (31.90/20.87)	REHVNLLRKHSLERFLKTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.19|      13|      28|     998|    1010|      15
---------------------------------------------------------------------------
  998- 1010 (21.83/13.83)	VVAEV.EADLHAGV
 1028- 1041 (17.36/ 9.49)	VVGDVrDAAAEFGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.72|      23|      24|     434|     457|      16
---------------------------------------------------------------------------
  430-  456 (28.34/28.89)	LkeaILLREGIN...EISYISLIPLKRRlF
  457-  482 (35.39/30.15)	M...VVLRLEIQsmkEMYFGELKHLHQK.F
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08856 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALLLQAGRHRQPRRPRADDNRPVHPHAPPRRRRQHELIPLPHPDHYS
2) MDGDAAAAAANATADADAGRDAGGDWRSKIRPDG
3) MRCAPVVLRNSPNRSLGQDEVPNSNTVQRQVQNSHFYANHTRQLPMQNSRHQSLLQSNMQQQPPREHFSLLPNQFQS
4) QVRQVIPSSIHEHLQSTSVGRQHHAPLNFGQLRSSSVRRQSISTPQKSIMPSREQLIGQRSNISNMQQR
5) SADNLGVTNAVPQLQTHQPSLMLLESQSQKTRHQPSQQQLYSDIQTMMQLQRESAMHQQPDSLKQETDDPQSSDSVLRPQNIIEDNKQSIPSNAETLVASSSSPVDTATQME
6) SVPEALRAIASKVEEKHFTTATSQGQPLAVPKVEHSPENTPLTPQNFRKITDSLTVHG
1167
1
119
211
301
53
1213
34
195
279
412
110










Molecular Recognition Features






MoRF SequenceStartStop




NANANA