<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08851

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceRSDAEKKVDLLKFVVRTRQRMLRLHVLAKWCQQVPLVHYCQQLAATLSSHDTCFTQTADSLFYMHEGLQQARAPLFDVPSAVEVLLTNGYQRLPKCIEDLGMQSTLSADEQKPALKKLDTLVRSKLLEAVIPKEVSEVTISDGIATLRVDGEFKVLLTLGYRGHLTLWRILHLELLVGEKRGPVKLEETQRYPLGDDLERRMASAENPFTILYTILHELCVAIVMDTVIRQVQVLRQGRWKDAIRFELISDGHAGGNTAILQLGQDGELESTGLRTPGLKITYWLDLDKNNSDSSPFIKIEPGQDMQIKCLHSSFVLDPLTDKEANFSLDQSCIDVEKLLLKAIACNRHTRLLEIQRELNKNVQICRAPSDVILKHEATEFEIDSRKKEDKQNIDEYFRDEILQVRAYGRSYITLGINIRNGHFLLQSSKNILSPSALSECEEALNQGTTTATEVFMSLRTKSILHQFASIGRFLGLKVYDQSLNTLKIPKSILYGSDLLLMAFPQCGNSYYLLMQLDKDFKPVFYLLETQPDPGGKSQSASDINQAIRFSKIDVGQMQISRNELSMSLFDWEKLQRLRNVESSNQILENGLLPERGMESRLQLPGYSKSTFSSVVDEVFEYEKGASRPNNHLSTSYSMPSFPQVGSLSYSPQGVAPAIGSSRSEGGLQHSPVNNAAKTSPGLLSSGGYLSTNMRGSLQNGAINALSASSSMRNSSIQKLASSKSGQDLSSLRSPKELSNIDGSRSHQLMPPQRSTGAQISVKSSYPNISKSTLASSLVESTAGQIAEFGNSSTPSFGSVGKLEKSSTKRSLSQLLLHISSLPVQSKRRKVSESVKSLSPALQLFSSVPTPTTNGFTYGNLLAEGNHSMTPNIFVSLLLHVVRHCSLCIKHAQLTSQMEALDIPYVEEVGLRTPSSSLWLRLPFARDDSWKHICLRLGKAGTMSWDVKINDPHFKELWELHRGSKSTAWGSGVRIANTSEMDSHIHYDSDGVVLTYKTVEADSIQRLVSDLKRLSNARLFACGMRRLIGVRGEDKIEDSQTSSEAKISSVTKGASDAVDRLSEQMRKTFKIEAVGLMSLWFSYGSMPMVHFVVEWEAGREGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMTVTVSAGYNPFNKQNTVMPSQGLLTSCSSSNNAQPASSNPTTTAGMMAQLSNHSLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKEGPSAGGSLPCPQFRPFIMEHVAQGLNALEPGFVGASNTNPSSGAQLSAPNPNRMNVPTTVGMTRPTSSVVANQVPGGLNRVTNAVLASSGLASGISAVPVRLSPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPGLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQPQQQQQAQNNTQEELAAGEINEICDYFSRRVASEPYDASRVASFITLLTLPISALREFLKLIAWEKGLSQAQGGDIATAQRARVELCLENHSGSTSADNSESSSSSTKSNIHHDRAHNSVDFALTFVLDPAHIPYMNVAGGAAWLPYCMSVRLRYSFGESQNSHVSFLAMEGSHGGRSCWLRYEDWEKCKQRVARTVEGANGTSLGDASQGKLRLVAETMQRTIQGYLQQMRDSPLSGGSAAT
Length1737
PositionTail
OrganismAnanas comosus (Pineapple) (Ananas ananas)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Bromeliaceae> Bromelioideae> Ananas.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index49.34
Isoelectric point8.57
Molecular weight190513.89
Publications
PubMed=27374615

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08851
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     338.34|      96|     136|    1139|    1237|       1
---------------------------------------------------------------------------
  683-  731 (44.03/14.82)	..LLSSGGYL......STNMRGSLQNGaIN...A.LSASSSMRNSS..IQKLASSKSGQDLSS..............................................
 1139- 1237 (156.87/78.43)	GPLLALGGAI.....RPARMTVTVSAG.YN...P.FNKQNTVMPSQGlLTSCSSSNNAQPASSNPTTTAGMMAQLSnhSLHAAAMLSAAGRGGPGLVPSSLLPFDVSVV
 1275- 1372 (137.44/61.32)	GP..SAGGSLpcpqfRPFIME.HVAQG.LNalePgFVGASNTNPSSG..AQLSAPN...PNRMNVPTTVGMTRPTS..SVVANQVPGGLNRVTNAVLASSGLASGISAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.15|      14|      68|      78|      91|       2
---------------------------------------------------------------------------
   78-   91 (24.99/15.76)	VPSAVEVLLTNGYQ
  149-  162 (25.15/15.91)	VDGEFKVLLTLGYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     244.90|      72|     159|     576|     651|       3
---------------------------------------------------------------------------
  534-  574 (26.14/ 9.10)	...................................PG.GKSQSASDINQAIRFSKidvGQMQiSRNELSMSlFDWEK..........
  576-  651 (120.00/86.32)	QRLRNVES..SNQILEngllPERGMESRLQL....PGYSKSTFSSVVDEVFEYEK...GASR.PNNHLSTS.YSMPSFPQVGSLSYS
  736-  806 (98.76/62.04)	KELSNIDGsrSHQLMP....PQRSTGAQISVkssyPNISKSTLAS...SLVESTA...GQI....AEFGNS..STPSFGSVGKLEKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     667.65|     227|    1138|     253|     507|       5
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  253-  507 (331.75/263.77)	HAGG..NTAILQLGQDGELESTGLRTPGLK.....ITYWLDLdknnsdSSPFIKIePGqdmQIKCLHSSFVLDpltDKEANFSLDQS.............CIDVEK..LLLKAIACNR.HTRLLEIQRELNKNVQICRAPSDVilkHEATEFEidSRK..KE..DKQNIDEYFRDEILQVRAYgRSYITLgINIRNGHFLLQSSKNILSPSALSE.CEEAlNQGTTTA..TEVFMSlRTKS.ILHQFASIGRFLGLKVYdqsLNTLKIPKSILYGSDLLLmafPQC
 1385- 1642 (335.89/198.77)	HMKGelNTAFIGLGDDGGYGGGWVPLAALKkvlrgILKYLGV......LWLFAQL.PG...LLKEILGSILKD...NEGALLNLDQEqpalrffvggyvfAVSVHRvqLLLQVLSVKRfHHQQPQQQQQAQNNTQEELAAGEI...NEICDYF..SRRvaSEpyDASRVASFITLLTLPISAL.REFLKL.IAWEKGLSQAQGGDIATAQRARVElCLEN.HSGSTSAdnSESSSS.STKSnIHHDRAHNSVDFALTFV...LDPAHIPYMNVAGGAAWL...PYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.52|      22|     136|     941|     962|       6
---------------------------------------------------------------------------
  941-  962 (46.52/30.10)	GTMS.WDVKINDP..HFKELWELHR
 1075- 1099 (36.00/21.55)	GLMSlWFSYGSMPmvHFVVEWEAGR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08851 with Med14 domain of Kingdom Viridiplantae
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