<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08846

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMNTTHLSVEERRTMEYLESVKTRLVQLHESIHFFLRSINPETTPGTVSWTELHSKFNVLIAKYLHLTNILNNPQITLQPRDYTVFPFEPPANDQQVQNLSVLLRTKLFPELEQADEERIREGTIPGLPVLPPSPAPNKAVNPNALNVPYGTPEEKKQWNVYKLKVAMHDELCRKADGIFEQQRDTVHTKVRYESDDDDEDGNEEDVAVGAENGGGGTKRERDTSGPSGAGISNKKSKVEANPLPTDEFLGGSSASVRYVDDWAGNLNDMDGYSSGADDQAGEGAGIEGDDVFDDSYFEARRREGALSSDGDDEEEEEESSEEELESLQGDESAEQSLDQGHGEEEDEEEDAFMEVVSPTAPISSQISSAGSNVSMVPAVETFEEEDDDDEEEMEEVGNV
Length399
PositionHead
OrganismMortierella elongata AG-77
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Linnemannia.
Aromaticity0.06
Grand average of hydropathy-0.858
Instability index59.14
Isoelectric point4.18
Molecular weight44163.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08846
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      86.99|      14|      39|     343|     356|       2
---------------------------------------------------------------------------
  193-  206 (24.61/11.83)	ESDDDDEDGNEEDV
  273-  286 (18.64/ 7.16)	SSGADDQAGEGAGI
  343-  356 (20.56/ 8.66)	EEEDEEEDAFMEVV
  383-  396 (23.18/10.71)	EEEDDDDEEEMEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.13|      23|      60|      73|      95|       3
---------------------------------------------------------------------------
   73-   95 (41.66/31.59)	PQITLQPRDYTVFPFEPPANDQQ
   99-  118 (26.45/16.98)	LSVLLRTK...LFPELEQADEER
  136-  157 (34.03/24.26)	PNKAVNPNALNV.PYGTPEEKKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08846 with Med8 domain of Kingdom Fungi
Unable to open file!