<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08844

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMEDPNAQQQGAAFPAPPYYFQRYTQPNLALLEKTKSDPTNPDLTTALDALPFPVLALEPPPPIKRGICWMFGRPWPVQDTLATLSEQGIEQLYPKGDIDRVKELKKLNHSAIFNFLDLVHVLSTSPGEFATKVDHIRVIFINMHHILNEYRPHQARETLRLMMNDQLDRKRKETAALRKTCADLRKQLAGLRALEQDRLVVPAGATASENNQDVDMAPATPEAASTSATVTEAGENGTAIGGSTSVTKKNAEAMSRMMQLCDTIE
Length265
PositionMiddle
OrganismMortierella elongata AG-77
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Linnemannia.
Aromaticity0.06
Grand average of hydropathy-0.439
Instability index45.27
Isoelectric point5.91
Molecular weight29389.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08844
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.36|      15|      15|     217|     231|       1
---------------------------------------------------------------------------
  202-  215 (17.62/ 8.72)	.PAGATASENNQDVD
  217-  231 (23.46/13.69)	APATPEAASTSATVT
  233-  247 (23.28/13.53)	AGENGTAIGGSTSVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.73|      16|      23|     106|     122|       2
---------------------------------------------------------------------------
  106-  122 (22.75/22.77)	KLNHSAIFnFLDLVHVL
  132-  147 (28.98/22.67)	KVDHIRVI.FINMHHIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.31|      13|      15|     148|     160|       3
---------------------------------------------------------------------------
  148-  160 (23.64/16.27)	NEYRPHQARET..LR
  164-  178 (16.10/ 8.92)	NDQLDRKRKETaaLR
  182-  192 (16.56/ 9.37)	ADLRKQLA..G..LR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08844 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VVPAGATASENNQDVDMAPATPEAASTSATVTEAGENGTAIGGSTSVTKKNAEAMSRMMQL
200
260










Molecular Recognition Features






MoRF SequenceStartStop




1) AAFPAPPYYFQRYTQPNLALLEKT
11
34