<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08832

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAIWNAPTTEIDPEALASTDMLYLAYTMARIRPVVPDVFVLQRLKDVQRIKGLTMETVILQFWLAGLTGLAESNSSSQRLLWKCLVLVKIPSIVSKLGYGYEELCDTVESTLRQLSFYRGILNECDDCVAEDGTGERADVLKSIAIGCRAKGLVRLDQLDILADVPSTHYDPEQYKFGKYSEQSPADAVNDLCGRTLSDFEHQEALLDRIIQVCEEAAANNDVLTLSKLCQTLDDNPLVVDLILLMRPPSSLLVPLESFVNNLQQNGDDDIDTCNSNLEGFGDVLILIMTIIRRYELAECLDSVLKDKQGFCYLWLHHTSATIPTASMSSMTTDMQGLMGRWISALFDSMGISDDLIQTSKPQMLLEISPSIFEQSLAACQAGVIDATTLNSGLDYFLQPCLLFVLIGVVQYLCQEIVFSAPSPLNSTHHSAHGASSASSMMSPTGTSPLASRGSASGSSGGKAGHTVTSGKSVAMMQSSLKSLLAGEAFPARLIRLLKSEISAALGHHAIENDHQLAIIHERLAETTVNYDSWKISEAYDVPKLAQQTVFAYDAIISGGRTPLVIKREKGWPVFGGSSYHLDVDLFRATLCYVGPAQFVTNILKRFLKAALTPNGRRAAELGAAMMTTPLVGCGDKHLSPQSLLWTLLCQTLWIPVPSRLETFTQGKHLATFVGMTLDMFQSSTFVQHRQEQLQQQQQEKGVDGTTATAAGEAASMEVDSSQTTTVAAAAAAAVGVSALEQLERDAAVEPFRVMLEQRLKVLEPIARDKPGFEGFIQGMAQYRERHPPLSLPLQGTSSTATTASSLRKVRMG
Length813
PositionTail
OrganismMortierella elongata AG-77
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Linnemannia.
Aromaticity0.07
Grand average of hydropathy0.012
Instability index43.41
Isoelectric point5.20
Molecular weight88588.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08832
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.78|      45|     563|      67|     112|       2
---------------------------------------------------------------------------
   67-  112 (72.96/54.26)	LTGLAESNSSSQRLLWK..CLVL.VKIPSIVSKLGYGyEELCDTVESTL
  631-  678 (73.83/49.53)	LVGCGDKHLSPQSLLWTllCQTLwIPVPSRLETFTQG.KHLATFVGMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.02|      49|     113|     241|     289|       3
---------------------------------------------------------------------------
  241-  289 (85.80/55.52)	DLILLMRPPSSLLVPLESFVNNLQ..QNGDDDIDTCNSNLEGF.GDVLILIM
  355-  406 (75.23/47.81)	DLIQTSKPQMLLEISPSIFEQSLAacQAGVIDATTLNSGLDYFlQPCLLFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.16|      18|      18|     423|     440|       4
---------------------------------------------------------------------------
  423-  440 (31.96/16.68)	SPLNSTHHSAHGASSASS
  443-  460 (31.21/16.14)	SPTGTSPLASRGSASGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      13|      18|      30|      42|       6
---------------------------------------------------------------------------
   30-   42 (22.52/17.07)	RIRPVVPDVFVLQ
   49-   61 (21.19/15.60)	RIKGLTMETVILQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.47|      37|     103|     465|     506|       7
---------------------------------------------------------------------------
  465-  506 (51.65/47.34)	GHTVTSGKS....VAMMQSSLksLLAGeafPARLI.RLLKSEISAAL
  571-  612 (57.82/37.57)	GWPVFGGSSyhldVDLFRATL..CYVG...PAQFVtNILKRFLKAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.31|      14|      14|     709|     722|       8
---------------------------------------------------------------------------
  709-  722 (22.53/15.88)	TAAGEAASMEVDSS
  725-  738 (20.78/14.05)	TTVAAAAAAAVGVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08832 with Med5 domain of Kingdom Fungi
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