<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08830

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLHDNFPTNVFSISELTSFGYTRYTHTCPARQFARQLNADSWSKAPSRSRSSAAGTQHNHNHHNSASAENLHPGHPESDPLLSAYISLLTARIPCHWHYSDKDKDKGKDKDKDKKNNPPQPNNSKQRRSSSSTAVFERELWVFWLNDKSLLENHGLEALQECQSGNMTWDSILQNNNSATAGTSQTSQAGSAESVSAAKEYEMFIRGLRNVLDRGMVAKGGYRLGSSYVFPASLQPRLDGSILPNFPKMPSMTMLSCTVTMYLSLTNLIFQPTFQHHRLRALEAADLDPRQASEKELKVLISPHGTPAILRLQDMAEFTEDQTQNCLDGWADHFGTNQELVNEFSRSLPRLVAVSVKTGRNEVVLQCPTERVFVPVSCKESPSDVGQLDGMGSRNLGFIEDLGAKFAVWSWQEKTRNAIASPAVPKLVQPVSEHTPVLAEPRNRLKAGSSAWQQQQQQIQQQLLQQQQQQQQQQQSQNFFLQQQQDALVKRSSNLPTYDTNRIDYWSYTDPYAYLTSIVLNSCANAEPKGADSPSAADNQVSVVVPVTPSAKPTRSRSNLARSTTGSKEVDGWIRVRPRRNAVAPPSTHNFGVLDTPDANQTAWSNGLDPESMPASEIESNTNNSTQFNANTSNDASQADAQNTSTNTSSYQLPIDLPADNNDMMSGLMDMNSIMGLYGTGNSDDLEDWGVVTKDDFSFFDEQPRSAPVARPLSTVQEPAFDSQQSSIPMSSTDLNMISGVSTAISSVIPTVNGVMSSFSEGMMTSSPIGDSGLMDNMDLDLSGLGNMMSPSTAILPPGGTDRLVAVSSSSAAISPSGDQSLALQAGQDVNMQTPKSQAVEKELNQLDGQHSHQPPPVPTSMQMSSPDTSVVKRPSILVTHLHSPIQSFIPSSFSPLKIVGDDLVDESKYKIGGRFAYRRLYKRRKPSVPDPLNLYRRESKMLPFYQPGKDQEWIMPPRKEKQRQKAKSQPFTNGIIWNGFQPGGSINIIQIGSQSAQKTTAMTRPGSLIRSASTPATAWGLSSYPLHSSLKRKKEEESSGDSDSDSSSNSSTNDSDDDSSIASGTFRPQFGRLLRTKDEAGRIEGEGQKDTWTLRGVNSARFVATILDQAMYTSAGNVLLDLDSVSTPQSMTAAKIAEWDSADAYHSEIEFDTPFTPVIFSSAPPALVEEPPAVHESLASEYFLEAVKTLCEQAVLGDYPFAGSNEVTGTSGEITEGESFHVMLARRKILSQQLNEGVATVPALGDESFRNVMEIKTVIFDLLGLLRGNPSDDTVALPVPSEAAQEMGMGITTLHGHHHHSSQSNIVPPVIMKGPLTLLQYFTLGEVQQMPSKYSKYQVKKKKTAEPALMQLLPPDIVVGHNDDWLEASPTILRFWEKLSLGPYSGRKSISYFVLYPESADMENNVTRFWRELSVLFETSLLGKHQPGMIQDYKPGLVPIPLLPALAGESMEARQVRSYIDGCQKLGSLLGADSKDKDVHTVIYMVNPFPHGAGYFDLCRCFSIMKTQFRTAMGSMSTPMEQPRENLVLQLVPIQHVINPSTFGGYLLFGLKDIAFTVYAKCKVFLERTTFSRDFLAQINTYAPLFALAKATPPTIHFDVHQKPNSMPKPPATLHVGYGFSLDGRWLICVWTDHRGELLEQFVLDMTESTGRMLMSGKSSCTNGNHSSSNRSLSLLTGIKEIWNRTLVYQKRGSFTWKTVISKLGLMSRTELQEWTRLTAGTNYTAVVAVNIDSAIRLYPHNRGAEYLSSGMTPNTSGVNTPTNAGLTQAAGLGVGTPLVGSNSLVPNITTSSTATPTPDVGTTPATPLNFGNTGNNAGSTGLGIAGAVAAGGGGLSGGAGGMAGIGGISGNEILENSAGQVYAMILNHRIPLIVSHQEAGLLRTARSGRRGRGREGESGSRLGNQTDAGETKPLGGPKEEPEEGEYDSKDIQLEDSVMNTPLADLDQDLDMEPKVKQEETSGQHVLLKAESIDEKELSSEQTPPPLPLLTGGNDVIVPLSSGYLIQAPIQSNSVMREKHALEALGIEVHLLHLQRIPTPTPSATHKPTAATPPPPRRPMTGREHLAAYRPSTKPMLHFQPVRSTAYHLSRIPALRPIASKYLPYRSSSSFSASQFSIRPPPAAASPTSSTSGRNSLSQSPGGSVGKGVLAPDTRGSGLGSIGNGAGGGGSSSTSGEKGSGGGGAGGGKGGERGGDKGGSATASTTIKGTVAASSTREILKQFHALSYLSQSPVQTNCLPNHLILVERLSRVLLLVRE
Length2259
PositionKinase
OrganismMortierella elongata AG-77
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Linnemannia.
Aromaticity0.06
Grand average of hydropathy-0.435
Instability index50.62
Isoelectric point6.27
Molecular weight244691.77
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08830
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.30|      15|      15|     453|     467|       2
---------------------------------------------------------------------------
  453-  467 (29.15/19.02)	QQQQQQIQQQLLQQQ
  470-  484 (30.15/19.92)	QQQQQQSQNFFLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.62|      17|      20|    2164|    2180|       3
---------------------------------------------------------------------------
 2164- 2180 (32.90/13.28)	GNGAGGGGSSSTSGEKG
 2183- 2199 (30.72/11.88)	GGGAGGGKGGERGGDKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.48|      16|      20|    1813|    1828|       4
---------------------------------------------------------------------------
 1813- 1828 (30.18/12.09)	GNTGNNAGSTGL.GIAG
 1833- 1849 (22.30/ 6.98)	GGGGLSGGAGGMaGIGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.21|      14|      20|    2072|    2085|       5
---------------------------------------------------------------------------
 2072- 2085 (27.36/22.41)	PSTKPML.HFQPVRS
 2094- 2108 (21.85/15.72)	PALRPIAsKYLPYRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.17|      15|      20|     790|     804|       6
---------------------------------------------------------------------------
  790-  804 (27.79/14.67)	SPSTAILPPGGTDRL
  808-  822 (25.38/12.64)	SSSSAAISPSGDQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.53|      11|      19|    1778|    1788|       7
---------------------------------------------------------------------------
 1778- 1788 (20.01/ 8.80)	TPLVGSNSLVP
 1799- 1809 (21.52/10.03)	TPDVGTTPATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.95|      12|      15|     863|     876|      11
---------------------------------------------------------------------------
  863-  876 (17.40/14.13)	QMSSPDTSVVkrPS
  881-  892 (23.55/12.30)	HLHSPIQSFI..PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.00|      26|      26|    1122|    1147|      16
---------------------------------------------------------------------------
 1122- 1147 (45.13/24.27)	DLDSVSTPQSMTAAKIAEWDSADAYH
 1151- 1176 (46.87/25.50)	EFDTPFTPVIFSSAPPALVEEPPAVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.67|      18|      20|    1444|    1461|      18
---------------------------------------------------------------------------
 1444- 1461 (29.76/21.93)	LPALAGESMEARQVRSYI
 1467- 1484 (28.91/21.03)	LGSLLGADSKDKDVHTVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.90|      19|      20|    1950|    1969|      19
---------------------------------------------------------------------------
 1950- 1969 (27.34/23.02)	DLDmEPKVKQEETSGQHVLL
 1973- 1991 (32.57/21.65)	SID.EKELSSEQTPPPLPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.59|      11|      19|    1614|    1624|      20
---------------------------------------------------------------------------
 1614- 1624 (21.43/14.39)	TLHVGY...GFSLD
 1633- 1646 (16.16/ 8.76)	TDHRGElleQFVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.48|      26|      34|     946|     977|      23
---------------------------------------------------------------------------
  946-  971 (48.72/37.38)	YQPGKDQEWIMPPRKEKQRQKAKSQP
  981- 1006 (43.76/20.02)	FQPGGSINIIQIGSQSAQKTTAMTRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.83|      22|      34|    1254|    1286|      24
---------------------------------------------------------------------------
 1254- 1280 (28.23/38.61)	MEIKTvifdLLGlLRGNPSDDTVALPV
 1290- 1311 (42.60/20.80)	MGITT....LHG.HHHHSSQSNIVPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.67|      19|      25|    2111|    2134|      26
---------------------------------------------------------------------------
 2111- 2134 (28.50/24.19)	SFSASqfsirPPPAAA....SPTSSTSG
 2137- 2159 (29.17/13.09)	SLSQS.....PGGSVGkgvlAPDTRGSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08830 with Med13 domain of Kingdom Fungi
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