<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08826

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNNIPQEGNRGGSISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLYVRLLALVKWANSASKVDKSTHIMAFLDKQSLLFVDTADMLARMARDTLVHARLPNFHIPAAVEVLTTGTYGRLPACIRERIVPPDPITPTEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVTFLIEQEFSVSLTVMGDGPTVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESTNPLSEVYHILHYFCQSLQLEVLYSQTLELTRKDPRSELGYRLTVQVDQHDPARPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRSRTLAGSPAILSVPILQPCLRAELLLVTVDTHTGMLQCHVPQYDAPLVPELTMALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPIVAFKEKESSPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDSGNNDQDGGCITEVVETSNNKRRSTGVGGRTDAAGTPQNRRPKHPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLKLVQLPAPSPSIATSSAWHALLKRLLSVSIRVQGKGMAKTWTVEFVFYGSPLSSSHPKEQGLRRPVYFQYEMGTADTVSRTVDVLLNDWAQIVHLYLIVHDLAEYFKMEKYNLRNMVSIKSYSYSKLVLAYGPNQGATVTIQWSTNDKAFKLVFGPTNTVTNAHSIMKEQLEAHLNRYTNLAQIIHILNDTLQPLTSISKLPSIPQLCVHARPRVPVQTFTIMPQCVTLVRIAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVDEFTPTQGLKAFLSKYVDENAVYRRRSQSEDDNPPSPVTMDSDGAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQANQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQGMASPAASNWPGSPSVPRPSPARPGQSPGHAALHSPQASDHKTGSHISRVLPQRSWAGAVPTLLTHEALEMLCCPSNHPSALPGPDMSPLERFLGCVYMRRQLQRFIQTEDCLTGINAEPGVVHFKSESLQCRVGLNPTHFQSLHIKVLSLPEYKDQWSVEELQIIEKFFDTRVAAPPYKHNTLSGFGRMLNVRFKVLKDFVQIMKLDLVPSLVQQQQLKWSVQLCLRIPPSAGPIVPPGTEGVHVCRSKILFFLQITRLGISYQGETPSLVLPFVHDVNTNITQLADRRDLTPPPSAMAAASMQLKRFAEYGANQSECSLFPAVRDLLANFTLPSEPPVISQVVPSPAGTQVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
Length1469
PositionTail
OrganismTrachymyrmex septentrionalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.06
Grand average of hydropathy-0.229
Instability index57.46
Isoelectric point8.39
Molecular weight162130.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08826
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     332.24|      75|      77|     954|    1028|       1
---------------------------------------------------------------------------
  948-  999 (81.50/24.88)	.....................GL.........RFH..pP..LTPPSGSNP.......HTPASP..HTANISQANQHQSFG.S.SPA.....TSFNLASPPSL
 1000- 1086 (115.28/37.70)	PPNTPNMLPHPSPG......SGLVANSPLNPMHVP..sPagLMPTSSPGPcsnvqvgHSPAGSfmQTGHIDGSPFPASQGmA.SPA.....AS.NWPGSPSV
 1087- 1134 (64.89/18.57)	........PRPSPA...............RPGQSPghaA..LHSPQASD........HKTGS...H...ISRVL..........PQ.....RSWAGAVPTLL
 1362- 1407 (36.48/ 7.79)	.........................................LTPPPSA.........MAAASM..QLKRFAEYGANQSEC.SlFPAvrdllANFTL...PSE
 1408- 1452 (34.10/ 6.88)	PPVISQVVP..SPAgtqvasAQQIQNTAMQ.MHSP..mAagQGPPQGPGP....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.25|      53|      76|     306|     368|       2
---------------------------------------------------------------------------
  306-  361 (82.65/44.92)	LTVQVDQHdpaRPLAVVHIPSLGSKESEIAHRAIRSDQLSMECLLVHTIYVRTRSR
  384-  436 (90.61/48.75)	LLVTVDTH...TGMLQCHVPQYDAPLVPELTMALNGDHSRLPTLISELRFWITQRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.22|      17|     131|     441|     457|       5
---------------------------------------------------------------------------
  441-  457 (30.91/18.07)	LQHLPATSHERLPIVAF
  573-  589 (30.31/17.58)	LAHVVALCDERIPFVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      14|      16|     808|     823|       6
---------------------------------------------------------------------------
  820-  838 (19.88/13.00)	QLCvharpRVPVQTFTIMP
 1294- 1308 (23.08/11.03)	QLC....lRIPPSAGPIVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.39|      21|     133|     705|     750|       7
---------------------------------------------------------------------------
  730-  750 (38.08/62.58)	MVSIKSYSYSK.....LVLAYGPNQG
  863-  888 (31.31/ 6.59)	LVSLRDGAYSRfdrsnVVDEFTPTQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      20|      56|    1264|    1284|      10
---------------------------------------------------------------------------
 1264- 1284 (31.30/25.73)	RFKVLKdFVQIMKLDL.....VPSLV
 1318- 1342 (29.84/18.76)	RSKILF.FLQITRLGIsyqgeTPSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.09|      39|     408|     223|     266|      12
---------------------------------------------------------------------------
  223-  266 (61.39/44.38)	WR.LLELEILVSDRETGDGKAlvhplQTRYVHQVVQSRLAESTNP
  632-  671 (66.70/37.47)	WHaLLKRLLSVSIRVQGKGMA.....KTWTVEFVFYGSPLSSSHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08826 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGGCITEVVETSNNKRRSTGVGGRTDAAGTPQNRRPK
2) TQVASAQQIQNTAMQMHSPMAAGQGPPQGPGPYGIQGMQPMGMMGGPPQ
3) VYRRRSQSEDDNPPSPVTMDSDGAGGNVSFLGHHRSGPQSPAQQREGLRFHPPLTPPSGSNPHTPASPHTANISQANQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPASQGMASPAASNWPGSPSVPRPSPARPGQSPGHAALHSPQASDHKTGSHISRVL
528
1421
902
564
1469
1121










Molecular Recognition Features






MoRF SequenceStartStop




NANANA