<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08819

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMRRPLRPFHHNPIRIAVENFSLVYPADEGHNRDDRSMYMTSFFHAIVLLLKIEAIEEAFSCVLVHHPKKETDKVAAWHQELRTAMTGLTKEQQEAAVRQFLSIAASMTNHRRLQLLLSLLENLVHSNFLPARLVCECILNCDKLQYQLEDFWIECFVLIKHILGGVDYKGVREIMKGCKEKAQTIPARLDASVQPQLKALENVIEFIFDRNACLLPGYFIVNEIQKAYPDGKNWPHWKLAKLLSDFVESFRHTAQMVSIVGHSKMLPVVEHTGYADYLINPWLLDPTTLKFSLKGNLPYDPDLLKPQTELLRYVLEQPYSRDMVCSMLGLQKQHKQRCVVLEEQLVELVILAMERSENETLPAEGMDGTVANHWVWLHLSSQLIYFILFQFACFPSIVMAIHDKLAGRELRKGRDHLMWVLLQFISGSIQRNPLSNFLPVLKLYDLLYPEKEPLPVPDYTQALCTHQMAITCIWIHLLKKAQTEPGTNIHRPIPHTLKVHHEFLQHLVMPNASLCMGSDYRIALLCNAYSTNQEYFSRPMAALVDTILGTQKNQQQQPLQNLQNNAALANGPTTPLSMSILDSLTVHSKMSLIHSIVTHVIKLAQSKSNMALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSHAWGTLYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRALVLTLARSMHVTGTGADSLSGTWCKELLNTIMQNTPHSWANHTLQCFPPVLSEFFQQNSVAKENKQQIKKAVEEEYRNWASMNNENDIIAHFSVPGTPPLFLCLLWKMILETDRISPIAYKILERIGARALSAHLRKFCDYLVFEFANSVGGQHVNKCVDTINDMIWKYNIVTIDRLVLCLALRTQEGNEAQVCFFIIQLLLLKAAEFRNRVQEFVKENSPEHWKQSNWHEKHLAFHRKFPEKFAPEGIMEQTSGGPSQYQNLPVYFGNVCLRFLPVFDIVVHRYLEIPPVIKSLEILLEHLGCLYKFHDRPVTYLYNTLHYYEKKLRDQPLLKRRLVSAVLGSLREIRAPGWALSEAYQMYMTRFNVDAVSWVPELDYYIRLVQRIVETMSGTAHFPATDWRFNEFPNPAAHALYVTCVELMALPVAPDAVANFLLDVVAKGYTVVPSDEIHLWINCVGLLLAALPECYWSALHKRLLETISSPGLINWQYNNLTPFQMFNFNITHNSLLENKYSYMLALAHSVWHHAGVGQITTMPQFIKEKLQPVVSSEEQLIYACHLIGPTLARFNAERPNCVAELAVCLYEMLERVDHTQTTLNYMDSICDLLISYSLMCLSKDFYVPFYIFLNNSDRYHIKYMFVGDTTKNEVECIIRRLRPALQMRLRFITHINIDEIHTS
Length1417
PositionTail
OrganismTrachymyrmex septentrionalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.10
Grand average of hydropathy-0.042
Instability index46.96
Isoelectric point6.92
Molecular weight162843.27
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.06|      21|     157|     531|     556|       1
---------------------------------------------------------------------------
  316-  336 (41.65/28.58)	EQPY.SRDM...VCSMLGLQKQHKQ
  532-  556 (30.42/33.84)	NQEYfSRPMaalVDTILGTQKNQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     421.24|     138|     558|     597|     746|       2
---------------------------------------------------------------------------
  597-  746 (206.65/152.11)	VTHVIKLAQSKSNMALAPALVETYSRllVYTEIESLGIKGFIS..QLLPTVFKSHAWGTLYT.LLEMFS......YRMHHIQPHYRVQL.LSHlHSLaavpQTNQTQLHLCVESTALRLiTGLGSAEVQPQlsrFLSEP.KTLVSAEsEELNRALVL...TLAR
 1156- 1307 (214.60/126.62)	VTCVELMALPVAPDAVANFLLDVVAK..GYTVVPSDEIHLWINcvGLLLAALPECYWSALHKrLLETISspglinWQYNNLTPFQMFNFnITH.NSL....LENKYSYMLALAHSVWHH.AGVGQITTMPQ...FIKEKlQPVVSSE.EQLIYACHLigpTLAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.44|      41|     261|     845|     887|       3
---------------------------------------------------------------------------
  845-  887 (64.60/47.76)	WKMIL...ETDRIS..P.IAY..KILERIgARALS..AHLrKFCDYLVFEFAN
 1098- 1148 (53.84/31.02)	YQMYMtrfNVDAVSwvPeLDYyiRLVQRI.VETMSgtAHF.PATDWRFNEFPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.43|      40|     309|     181|     228|       6
---------------------------------------------------------------------------
  183-  225 (61.01/55.12)	QTIPAR.LDASVQPQ...LKALENVIEFIFDRNAClLPGyfIVNEIQ
  359-  402 (63.41/31.63)	ETLPAEgMDGTVANHwvwLHLSSQLIYFILFQFAC.FPS..IVMAIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.67|      20|     203|     285|     310|       9
---------------------------------------------------------------------------
  289-  309 (33.08/32.31)	LKFsLKGNLPYDP...........DLLKPQTE
  422-  452 (28.60/ 7.45)	LQF.ISGSIQRNPlsnflpvlklyDLLYPEKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.86|      52|     889|      22|      80|      13
---------------------------------------------------------------------------
   22-   80 (77.59/64.43)	LVYPADEGHNRDdrsmymTSFFHAIVLLLKIEAIEEAFScVLVHHPKKETDKVAAWHQE
  920-  971 (90.27/54.86)	LALRTQEGNEAQ......VCFFIIQLLLLKAAEFRNRVQ.EFVKENSPEHWKQSNWHEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08819 with Med23 domain of Kingdom Metazoa
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