<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08813

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVTLAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGSGNNQPSTPTSSSQSVTGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNVESNNNPQSPSITKNEVNVAFNDYLTCAHHRDVIYSLATIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYAKIFTPPPKDNSNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDMDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYIVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKIDIPLSHSTKGGGPASVGVGVGVSSSGPGELSISHILGTSDILGGGDDLGLDLAMSSSSSSVGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSSELSQWLDTVAKAAIDVFQLNNTLSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2197
PositionKinase
OrganismTrachymyrmex septentrionalis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.06
Grand average of hydropathy-0.506
Instability index52.65
Isoelectric point7.53
Molecular weight244537.55
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08813
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     310.96|      22|      22|    1989|    2010|       1
---------------------------------------------------------------------------
 1823- 1846 (26.38/ 7.01)	QQMA.fgNQQAPVAQQPGMFT.....GQ..PP
 1847- 1866 (30.66/ 9.40)	QP.....QQQWYSNQQTHTPA.....QQ..YG
 1905- 1924 (27.60/ 7.69)	NQFM...GSQQQPP..TATPV.....AG..PG
 1950- 1981 (27.67/ 7.73)	QQGMfaaQQQQQQQQQQQQQGiyagiQQgmNQ
 1989- 2010 (43.98/16.85)	QQMM...QQQQQQQQQTSQQT.....QQ..QQ
 2012- 2028 (34.37/11.47)	QQLL...QQQQQQQQQ..........QQ..QQ
 2029- 2050 (31.95/10.12)	QGIL...NQQQSMMFPNQQQM.....MG..PQ
 2053- 2074 (26.61/ 7.13)	QEYM...PQQRMQPSAARPPY.....LQ..AP
 2136- 2149 (24.94/ 6.20)	QQML...AMQQQQQQA...............Q
 2150- 2171 (36.79/12.83)	QQQA...AQQQQQQQQGAAGG.....QQ..PT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.17|      30|      39|      89|     127|       2
---------------------------------------------------------------------------
   89-  118 (53.90/42.25)	KRQQINPKDNFWPVTARTKNGI..EAWFKDLS
  129-  160 (49.27/23.11)	KAPNFNKKEEIFMMLCEYQVPMlrAAWFIKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.72|      15|      15|    1231|    1245|       3
---------------------------------------------------------------------------
 1231- 1245 (25.37/14.38)	STKGGGPASVGVGVG
 1247- 1261 (25.35/14.37)	SSSGPGELSISHILG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      19|    1022|    1037|       4
---------------------------------------------------------------------------
 1022- 1037 (27.65/17.39)	CNAIVAVCSETDNDKL
 1044- 1059 (30.04/19.55)	CAELTACCNALNAEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      15|     273|     287|       5
---------------------------------------------------------------------------
  273-  287 (25.11/20.56)	EDGILKLLLPLALQY
  289-  303 (24.90/20.30)	EEFIQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.15|      18|     156|    1928|    1946|       6
---------------------------------------------------------------------------
 1928- 1946 (30.14/23.16)	GMQRQFiRQQLRAQHGAPG
 2087- 2104 (35.01/21.90)	GVQNQP.APPYRQSAGKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      12|      39|    1299|    1310|       7
---------------------------------------------------------------------------
 1299- 1310 (22.54/13.27)	AHHVLRQICSQE
 1339- 1350 (23.38/14.06)	AQKLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.40|      15|      15|     451|     465|       8
---------------------------------------------------------------------------
  451-  465 (26.03/14.66)	DALDRHSFDKMDASN
  468-  482 (27.37/15.81)	DTLYAKIFTPPPKDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.47|      27|      45|    1419|    1445|      11
---------------------------------------------------------------------------
 1419- 1445 (44.65/25.35)	NKSDKKSGSIWLVAPLVSKLPSAVQGR
 1466- 1492 (46.82/26.95)	ERGRSKSPSLFNHQPFLSLVLTCLKGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08813 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) NYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
3) THSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQGIYAG
670
1982
1726
710
2197
1974










Molecular Recognition Features






MoRF SequenceStartStop




1) MMGILYEKRPLK
2) NMLRLRL
3) QQPTPQLVTHLQRHL
4) TLYAKIF
1
1896
2168
469
12
1902
2182
475