<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08803

Description CREB-binding protein
SequenceMPPLLMHPAYTNYGGGGSGNMQQIQAPPQQLHLQQHPLQHWNNNTIQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMSTRAVAMQQQQQAHMVGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTSAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGPQQATQGQMPGAGAPTGAKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQANGAMRQCTLPDCKTMKNVLNHMTNCQAGKNCTVPHCSMSRQIINHWKYCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRKAYEALGIQCPTTTPGILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPVQGTKEWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPSNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQQHNRMQFPQQQQAQQQQAQQQQQVQAQQQIQQQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGPQMSQANLTTTTASNNATTSQFPTSNGTTAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQSQQQPQPTSAPSQVGTPATSIPQAPSPFSGMQQPNAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPVTTAGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPQDTTTSDIKPLVPEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAMQTGQQTSNVAMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHVSYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRALVHQQQPGQHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQPQQQQPQQQTQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVAQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPASMPHHSSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2516
PositionKinase
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.04
Grand average of hydropathy-0.718
Instability index58.79
Isoelectric point9.22
Molecular weight273391.25
Publications









Function






Annotated function

Acetyltransferase enzyme. Acetylates histones, giving a
specific tag for transcriptional activation.



GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08803
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     672.04|      58|      58|    2248|    2305|       1
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  873-  919 (65.49/13.09)	MGQLATIPAMAIQQHNRMQF.......PQQQQA......................QQQQAQQ.Q.....QQV....QA..........QQ....................QIQQQ..Q..........
  920- 1001 (51.54/ 8.44)	QQQQGI.LVGPPGPSPNGQStsnanmvPNPGLS.......................PFGPQM.SQANLTTTT....AS..........NNattsqfptsngttaglpnssPIQNQ.HQ...FPD...L
 1002- 1051 (76.10/16.63)	M.KVRLAQAQAQAAQQQQQQ.......QQQQQQ......................SQQQPQP.T....SAPS....QV..........GT....................PATSI.PQ.....A...P
 1052- 1115 (59.52/11.10)	..SPFSG.MQQPNAQQPQQQ.......PQQQSN......................QQFPTRPlSA...TTPN....DNgiatstpqtiPP....................P..AS.SGP..SPTggvP
 2124- 2179 (69.23/14.34)	MQQ...NPNLARQQTPQQLM........QQQQQ......................QQHQAQP.GMGMGAQMA....RQ..........PG.................vigPVGQVgPQA..ST.....
 2180- 2246 (46.98/ 6.91)	MHKHALQQLMQTLRSP.H.T.......PDQQNQilqilksnpplmaafikqralvHQQQPGQ.HGGGVGGPL....GP..........NQ....................P.................
 2248- 2305 (101.70/25.17)	QQQPGLQHMMSQQQQPQQQQ.......PQQQTQ......................QQQQGRL.QIQMLTQQA....QQ..........QQ....................PVQAQ.SQW..YKQ...Q
 2309- 2364 (77.20/17.00)	MQQR..QQQVAQQQQQQQQQ.......QQQQQQ......................QQQQP.......FTQPPappyGQ..........QR....................PIRPL.LGYggFNE...Q
 2366- 2415 (76.86/16.89)	YGQPGLKPTPPPVPSPQGVM.......GPPGIS......................VQQQ........LMQSV....RS..........PP....................PIRS..PQP..NPS...P
 2426- 2465 (47.41/ 7.06)	VPSPRSGPVPSPHHHPPHGT.......PTHSPA......................HELGGGP.SEMMLSQ..........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      17|      18|    1130|    1146|       2
---------------------------------------------------------------------------
 1129- 1145 (34.38/17.06)	T.STPNTPLVPSLMTPNQ
 1165- 1182 (23.39/ 8.60)	TtTSDIKPLVPEPIQPSG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.87|      20|      21|     415|     435|       3
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  342-  361 (27.21/ 7.63)	YGSPNTVGPGAGV.TVCSNNP
  415-  435 (35.66/17.87)	PPAPSPAQPQSGApTGGQPGP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     161.81|      21|      21|     489|     509|       4
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  489-  509 (39.60/20.62)	RQ.....CTLPDCKTMKNVLN....HMTNC
  513-  533 (40.86/21.51)	KN.....CTVPHCSMSRQIIN....HWKYC
  536-  553 (23.65/ 9.31)	SD.....C..PVCLPIKQANK....NRTN.
 1902- 1922 (37.04/18.80)	AN.....CRLPSCQKMKRVVM....HTKNC
 1923- 1947 (20.66/ 7.19)	KRktnggC..PIC...KQLIAlccyHAKHC
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     339.94|      79|      83|     562|     643|       5
---------------------------------------------------------------------------
  562-  621 (96.40/32.72)	.................................P.NNQPNTSPSEMRKAYEALGIQCPTTTP...GILPGQGVGR..GVRMPA.PGM..AGPPGAL.GNVRLA
  623-  708 (96.40/37.43)	PQTQAAP..GQSVV......GAGQQvvAPnvslPlNSDPSTVGVAGNQT.......VPTTGPtsaAAAAAANIQQ..SVNMQTlFGLneSGQPGVIgGENRLA
 1987- 2033 (64.68/18.94)	...................................NTRP.TGPVAMQTGQQTSNVAM.TTGV...AMKPG..VST..S.NLPT.P.....HQPG.I.G.LK..
 2034- 2105 (82.47/25.28)	PGTQTPPahVLQVVkqvqeeAARQQ..AP....H.VSYGKVTPGGGV....GVGVGVGGQTG...GVMPPPQMQRplPVQMPN.P....SG............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     243.14|      51|      51|     178|     228|       6
---------------------------------------------------------------------------
   53-  119 (46.76/13.47)	SNTEMfDLENDLpD..DL..LS......SGSW.G...SttestK.PPATGPGpGQQNGALDTElrqhvqqqqQLSHHLIQQQ
  178-  228 (89.82/32.85)	ANNQM.SIANSM.G..GL..QS......SMSMAG...S.....N.PAMSMPG.GMNSGLVMTS.........TASGNNMGGM
  229-  276 (61.87/20.27)	AGGSL.IVTNSL.NkqPL..NT.......VTMMG...P.....NtQAIHHPG.APH.GV.............TPMQNGPGMM
  282-  331 (44.68/12.53)	AMQQQ.QQAHMV.G..PArgQSphqqvhQVGIVGpgqG.....G.PRMQAPP.NM.....................ANMPTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     150.68|      36|      72|    1313|    1348|       8
---------------------------------------------------------------------------
 1200- 1238 (24.40/ 9.42)	.ALMPT..LEKLYRQDpESIPFRQP...V......................................dPQALG..IpdYPtivK...K
 1242- 1276 (36.50/17.99)	LSTIKKklDTEKYS...DPWEYVDD...VW.................................mmFD.NAWL......YN...R....
 1277- 1324 (25.55/10.24)	.....K..TSRVYR.......YCTKlseVF...............eqeidpvmqalgyccgrkytFN.PQVLC..C..YG...K...Q
 1325- 1399 (37.74/18.87)	LCTIPR..DAKYYSYQ.NRYTFCQK...CFndipgdtvtlgddptqpqtaikkeqfqemkndhleLE.PFVTCtdC...G...RrvhQ
 1400- 1436 (26.49/10.90)	ICVLHM..EA..I.WP.LGFT.CDN...CL........................kkkgqkrkenkFN.AKRL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.01|      39|      49|    1729|    1774|      10
---------------------------------------------------------------------------
 1729- 1773 (57.22/49.96)	GNdlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1778- 1825 (52.80/25.88)	GR..dA..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.14|      27|      56|    1547|    1574|      11
---------------------------------------------------------------------------
 1547- 1574 (45.73/45.74)	RPRQFRTAVYHeILLGYLD.................YAKQLGYTM
 1581- 1617 (26.43/18.54)	PPSEGDDYIFH........chpaeqkipkpkrlqewYKKMLDKGM
 1618- 1631 (16.98/ 8.39)	VER.........IVLDYKD.................ILKQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.72|      17|      36|     362|     380|      12
---------------------------------------------------------------------------
  362-  380 (24.38/21.53)	VG...VVKPQQkGvGTNMSPMQ
  395-  414 (25.33/11.89)	IGttnVVGGQE.G.GTAAQQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.39|      13|      19|     737|     749|      15
---------------------------------------------------------------------------
  737-  749 (24.55/12.99)	TPDLRNHL...VHKLV
  755-  770 (20.83/ 9.82)	TPDPQAMLdkrMHNLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.90|      20|      21|    1841|    1860|      16
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 1850- 1872 (28.35/14.58)	KDGHPHPMEKLgFDLddGS.......SPAD
 1874- 1901 (24.56/11.48)	KQTNPQEARKLsIQR..CIqslvhacQCRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.50|      17|     107|     709|     729|      17
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  711-  727 (29.06/ 9.67)	QLPGGLQPGQVTATPVQ
  831-  847 (35.48/11.15)	QPPGTSGPGLRPCAPSN
  857-  872 (24.96/ 6.51)	KPVGTVPPTLRSHSPS.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08803 with Med12 domain of Kingdom Metazoa
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