<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08793

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGSGNNQPSTPTSSSQSATGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNVESNNNPQSPSITKNEVNGSKDTTVAAQGSLNLLTVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYAKIFTPPPKDNSNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDVDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMMDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKVDIPLSHSTKGAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSSELSQWLDTVAKAAIDVFQLNNTLSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHTRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQSAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2159
PositionKinase
OrganismTrachymyrmex cornetzi
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Trachymyrmex.
Aromaticity0.06
Grand average of hydropathy-0.511
Instability index51.67
Isoelectric point8.00
Molecular weight240676.36
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     253.85|      25|      25|    1799|    1823|       1
---------------------------------------------------------------------------
 1799- 1822 (43.56/16.63)	..........QMAFGNQ...QAP.V.AQQPG.MFTGQ.PPQ
 1823- 1849 (29.41/ 8.73)	P........qQQWYSNQ...QTH.TpAQQYG..YSQQlPPT
 1865- 1888 (24.62/ 6.05)	S.........KQALSNMlrlRLP.S.NQ.....FMGS.QQQ
 1910- 1935 (34.19/11.40)	R.........QQLRAQH...GAPgI.NPQQG.MFAAQ.QQQ
 1967- 1988 (34.76/11.72)	..........QMM..QQ...QQQ.Q.QQQTS.QQTQQ.QQQ
 1989- 2018 (25.16/ 6.36)	QqqgilnqqqSMMFPNQ...Q......QMMG.PQRGQ.EYM
 2039- 2064 (25.17/ 6.36)	T.........MNAMGPM...GAG.V.QNQPApPYRQS.AGK
 2107- 2133 (36.98/12.96)	Q.........QQAQQQQ.aaQQQ.Q.QQQQS.AAGGQ.QPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.12|      36|      41|      61|     100|       2
---------------------------------------------------------------------------
   61-  100 (56.55/56.62)	VTA.AKVG..AYFNAILAKKEELAtmpdTGRKRQQINPKDNFW
  102-  140 (52.57/39.65)	VTArTKNGieAWFKDLSGSKPLVA....LAKKAPNFNKKEEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.35|      14|      41|    1850|    1864|       3
---------------------------------------------------------------------------
 1850- 1864 (24.99/20.54)	PVGGPRyERPGMNNQ
 1894- 1907 (28.37/17.21)	PVAGPG.AFQGMQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.14|      31|      41|    1052|    1086|       4
---------------------------------------------------------------------------
 1052- 1086 (41.43/43.14)	DKLNDIAItcAELTAcCNALnAEWLGVLMALCCSS
 1094- 1124 (53.71/34.31)	DVLNQVDV..QDLSI.HNSL.AIFTSILIARHCFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.04|      43|      44|    1378|    1420|       5
---------------------------------------------------------------------------
 1342- 1387 (52.87/34.28)	LEN....LE.QWSLRMS...WLDLQLMYKqfTPSSSElsqwlDTVAKAAIDVFQ
 1388- 1430 (69.35/47.68)	LNN...TLS.NKSDKKSGSIWLVAPLVSK..LPSAVQ.....GRVLKVAGQVLE
 1431- 1467 (33.83/18.78)	SGNwskTAGrERGRSKSPSLFNHQPFLSL..VLTCLK.....GQ..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      12|      42|    1274|    1285|       7
---------------------------------------------------------------------------
 1274- 1285 (22.54/15.75)	AHHVLRQICSQE
 1314- 1325 (23.38/16.68)	AQKLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.04|      19|      41|    1669|    1687|       9
---------------------------------------------------------------------------
 1669- 1687 (36.11/22.64)	NPAPLSWAWFRAVRLERKP
 1713- 1731 (35.93/22.49)	DPPPLPPEDLEPDKKESEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      19|      39|     863|     884|      11
---------------------------------------------------------------------------
  863-  884 (24.08/21.52)	ELALNIYGLI...DVCIqILKelPE
  903-  924 (29.64/15.19)	NLSLYVVGVLrryHCCL.LLS..PE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.98|      38|      47|     671|     716|      14
---------------------------------------------------------------------------
  679-  716 (65.59/47.64)	DSKIDDDLDKIL...QHIKEDQQNSMDAPDSPKEDALT.GHG
  722-  763 (61.38/28.53)	DSKMPSSHSRHLlytTHFPLPQDETCSQHDCNQRHVLLyGVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      15|     273|     287|      15
---------------------------------------------------------------------------
  273-  287 (25.11/17.31)	EDGILKLLLPLALQY
  289-  303 (24.90/17.09)	EEFIQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.72|      14|      33|     983|     996|      16
---------------------------------------------------------------------------
  983-  996 (24.22/13.54)	KIRAALYSTLQPTP
 1018- 1031 (26.49/15.57)	KIEPQWARQLNETP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08793 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) NYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQSAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
3) THSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMKNKRHTRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQQQQGIYAG
687
1959
1701
727
2159
1951










Molecular Recognition Features






MoRF SequenceStartStop




1) MMGILYEKRPLK
2) NMLRLRL
3) QPTPQLVTHLQRHL
4) TLYAKIF
1
1871
2131
486
12
1877
2144
492