<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08777

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGSANNQPSTPTSSSQSATGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNVESNNNPQSPSITKNEVNGSKDTAVVVQGPLNVLTVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLRVAQENIKARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYTKIFTPPPKDNSSERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDVDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKVDIPLSHSTKGGPASVGVGVGVSSRFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSSELSQWLDTVAKAAIDVFQLNNTSSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGSNVGNTGIGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMMQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRIQPGAARPPYLQAPNVTMNAMGPMGTGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2165
PositionKinase
OrganismCyphomyrmex costatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Cyphomyrmex.
Aromaticity0.06
Grand average of hydropathy-0.512
Instability index51.59
Isoelectric point8.07
Molecular weight241426.18
Publications









Function






Annotated function


ECO:0000256	ARBA:ARBA00003861

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP08777
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     462.24|      56|      56|    1919|    1974|       1
---------------------------------------------------------------------------
 1784- 1838 (71.07/23.45)	......QQM..QQPPSQL........QQmafGNQQ...apvAQQP......GMFTGQPPQ..PQQQwyS...NQQT..HTPAQQ.....Y....GY
 1848- 1894 (46.08/12.82)	GGpryeRPG..MNNQSKQalsnmlrlRL...PSNQ..................FMGSQQQ..PPT..............AT.......PV...AGP
 1895- 1956 (100.70/36.06)	GA....FQG..MQRQFIR........QQ...LRAQhgapgiNPQQ......GMFAAQQQQ..QQQQ..Q...QQQG.IYAGIQQGMNQNY...AGY
 1957- 2009 (88.01/30.66)	GG....QQM..MQQQQQQ........QQ...TSQQ....tqQQQQ......QQLLQQQQQ..QQQQ..Q...QQQG.ILNQ.QQSM..MF...P..
 2010- 2070 (75.15/25.19)	NQ....QQM..MGPQRGQ........EY...MPQQ......RIQP......G..AARPPY..LQAP..NvtmNAMGpMGTGVQNQPAPPYrqsAGK
 2071- 2104 (32.93/ 7.22)	PG....A......................................vgvtgvGTANVSLQQ..NQQF..Q...QQQA.....INQRMRQ........
 2105- 2141 (48.32/13.77)	.......QMlaMQQQQQQ.....................................AQQQQaaQQQQ..Q...QQQG.A.AGGQQPTPQ........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.47|      27|      46|    1390|    1416|       3
---------------------------------------------------------------------------
 1390- 1416 (44.65/26.35)	NKSDKKSGSIWLVAPLVSKLPSAVQGR
 1437- 1463 (46.82/28.00)	ERGRSKSPSLFNHQPFLSLVLTCLKGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.60|      36|      41|      83|     118|       4
---------------------------------------------------------------------------
   83-  118 (64.31/39.30)	MPDTGRKRQQINPKDNFWPVTARTKNGI..EAWFKDLS
  123-  160 (56.29/33.49)	LVALAKKAPNFNKKEEIFMMLCEYQVPMlrAAWFIKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.99|      29|      46|    1651|    1683|       5
---------------------------------------------------------------------------
 1651- 1683 (47.78/33.56)	SQRVSAWELLEghknPAPLSWAWFRAVRLERKP
 1699- 1727 (54.21/28.62)	SQIRPASHYLD....PPPLPPEDLEPDKKESEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      15|     273|     287|       6
---------------------------------------------------------------------------
  273-  287 (25.11/15.83)	EDGILKLLLPLALQY
  289-  303 (24.90/15.62)	EEFIQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      19|    1039|    1054|       8
---------------------------------------------------------------------------
 1039- 1054 (27.65/18.50)	CNAIVAVCSETDNDKL
 1061- 1076 (30.04/20.77)	CAELTACCNALNAEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      12|      42|    1270|    1281|      10
---------------------------------------------------------------------------
 1270- 1281 (22.54/15.37)	AHHVLRQICSQE
 1310- 1321 (23.38/16.28)	AQKLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.65|      17|     177|     735|     757|      16
---------------------------------------------------------------------------
  488-  504 (32.20/11.28)	YTKIFTPPPKDNSSERD
  735-  751 (34.46/27.53)	YTTHFPLPQDETCSQHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08777 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) NYAGYGGQQMMQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYMPQQRIQPGAARPPYLQAPNVTMNAMGPMGTGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
3) THSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVGSNVGNTGIGNVNTNGKGKAMKNKRHNRRAKGAATPTTPISQQMQQPPSQLQQMAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQ
687
1952
1697
727
2165
1933










Molecular Recognition Features






MoRF SequenceStartStop




1) LYTKIF
2) MLRLRL
3) MMGILYEKRPLK
4) QPTPQLVTHLQRHL
487
1868
1
2137
492
1873
12
2150