<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08773

Description CREB-binding protein
SequenceMADHLVDGPPPKRPKLDPFQGTSDSTVVGMPPLLMHPAYTNYGGGGSGNMQQIQAPTQQLHLQQHPLQHWNNNTVQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMVGPARGQSPHQQVHQVGIVGPNQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTGAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGPQQATQGQMPGAGAPAGAKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQANGEVRQCALPDCKTMKNVLNHMTNCQAGKNCTVPHCSMSRQIINHWKHCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRRAYEALGIQCPTTTSGILPGQGVGRGVRMPGPGMTGPPGALGNVRLAQPQTQNFYEKSNKRWAPMCVSAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVASNQTVPTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPMQGTKDWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANTRSEYYHLLAEKIYKIQKELVNTYQNTYTKRDLSNNVDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQQHNRMQFPQQQQAQQQQQAQQQQQVQAQQQIQQQQQQQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGQPQMSQANLTTTTASNNATTSQFPTSNGTSAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQQQSQQQPQPTSTPSQVGTPATSIPQAPSPFSGMQQSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPVTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKVPEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKEKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAAMQAGQQTSNVGMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHINYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQPNTVMQQNPNLARQQTPQQLMQQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRALVHQQQPGQHGGGVGGPLGPNQPQQQPGLQHMMSQQQQPQQQQPQQQAQQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVAQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2586
PositionKinase
OrganismCyphomyrmex costatus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Cyphomyrmex.
Aromaticity0.05
Grand average of hydropathy-0.732
Instability index58.61
Isoelectric point9.24
Molecular weight281322.96
Publications









Function






Annotated function

Acetyltransferase enzyme. Acetylates histones, giving a
specific tag for transcriptional activation.



ECO:0000256	ARBA:ARBA00002581

GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08773
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.48|      15|      16|     957|     971|       1
---------------------------------------------------------------------------
  959-  976 (28.44/ 7.36)	QAQQQQQAQQQQQvqaQQ
 1130- 1144 (27.74/ 6.95)	SAQQPQQQPQQQS...NQ
 2204- 2218 (26.48/ 6.22)	TPQQLMQQQQQQQ...QH
 2386- 2400 (32.81/ 9.89)	VAQQQQQQQQQQQ...QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     608.47|      89|     104|     883|     986|       2
---------------------------------------------------------------------------
  873-  979 (149.16/38.80)	KRKEQQQ............lqaQQQQ....Q.QQ...QP..TQPP....GTS........GPGLRPC..............APP.....NVGTVM.....PGASKPVGTVPPTLRSHSPSMG....QLATIPAMAIQQH..........NR.MQ.........FP........QQQqaqqqqqaqqqqqVQAqqQI..Q
  980- 1084 (116.04/28.33)	QQQQQQQ...............QQQQgilvG.PP...GP..S.PN....GQStsnanmvpNPGLSPF..............GQPqmsqaNLTTTT.....ASNNATTSQF.PT..SNGTSAG.....L...PNSSPIQ...........NQ.HQ.........FPdlmkvrlaQAQ.............AQA..AQ..Q
 1085- 1123 (49.49/ 7.29)	QQQQQQQ...............QQQQ....QsQQ...QP...QP......TS........TPS..QV..............GTP.......ATSI.....PQAPSP.............................................................................................
 2117- 2203 (116.47/28.46)	KQVQEEA...............ARQQ....A.PHinyGK..VTPG....GGV........GVGVGVG..............GQT.......GGVM.....PP...PQMQRPLPVQMPNPSGT....HL..IP.MD.QWT..........AR.YQ..........P...ntvmqQNP.............NLA..RQ..Q
 2219- 2335 (100.76/23.50)	QAQPGMG...............MGAQ....M.AR...QPgvIGPV....GQV........GPQASTM..............HKH.....ALQQLMqtlrsPHTPDQQNQILQILKSNPPLMAafikQRALVHQQQPGQHgggvggplgpNQpQQ.........QP..glqhmmSQQ.............QQP..QQ..Q
 2380- 2490 (76.56/15.85)	.QQRQQQvaqqqqqqqqqqqqqQQQQ.......Q...QP.fTQPPappyGQQ............RPIrpllgyggfneqgyGQP.....GLKPTP.....PPVPSP..........QGV.MG.......P.PGISVQQQ...........L.MQsvrspppirSP........QPN.............PSP..RPvpS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      15|      16|    2071|    2085|       4
---------------------------------------------------------------------------
 2071- 2085 (28.59/12.17)	TSNVGMT..TGVAMKPG
 2088- 2104 (25.18/ 9.81)	TSNLPTPhqPGIGLKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     242.64|      48|      51|    1147|    1194|       6
---------------------------------------------------------------------------
 1147- 1186 (67.29/25.41)	..............PTRPL..SATTPNDNGIA.........TSTPQTIP......PPASSGPS.PTG....G.......V..PVT
 1187- 1247 (56.34/19.86)	TTGTTNGPqsttstPNTPLvpSLMTPNQT.VS.........SASNQT.P......PHSGPTPS.PAGlaslG......kVpePIQ
 1248- 1302 (44.75/13.98)	PSGTSTDKkkclfkPDELR..QALMPTLEKLY.........RQDPESIPfrqpvdPQALGIPDyPT...................
 2512- 2574 (74.25/28.93)	PHGTPTHS......PAHEL..GG.GPSEMMLSqlgggpgapTGHPATMP......HHPSPAPA.PTN....GgadanevT..PMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.88|      19|      21|     444|     464|       7
---------------------------------------------------------------------------
  281-  302 (31.34/ 8.66)	PNTQAIHHP..GAPHGVTPmqnGP
  444-  464 (35.55/15.29)	PPAPSPAQPqsGAPTGGQP...GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     174.02|      21|      21|     518|     538|       8
---------------------------------------------------------------------------
  518-  533 (22.53/ 6.77)	..........R..QCALPDCKTMKNVLN
  534-  557 (34.11/13.77)	HMTNC..qagK..NCTVPHCSMSRQIIN
  558-  582 (32.21/12.62)	HWKHCnrsdcP..VC.LPIKQANKNRTN
 1963- 1985 (35.68/14.72)	HACQC.....RdaNCRLPSCQKMKRVVM
 1986- 2006 (26.45/ 9.14)	HTKNCkrktnG..GC..PIC...KQLIA
 2011- 2029 (23.04/ 7.08)	HAKHC...qeT..KCLVPFCSNIK....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      49|    1797|    1842|       9
---------------------------------------------------------------------------
 1797- 1841 (59.91/60.59)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1846- 1893 (59.49/36.83)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      19|      19|     190|     208|      10
---------------------------------------------------------------------------
  190-  208 (32.32/19.67)	QMVV..SLGNLPSSIASSLAN
  210-  230 (30.18/17.80)	QMSIanSMGGLQSSMSMAGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.17|      26|      50|     614|     640|      11
---------------------------------------------------------------------------
  614-  635 (34.86/12.93)	...............................PTTTSGILPGQG.VGRGVRMPG...P
  636-  688 (24.57/ 8.92)	GMTGppgalgnvrlaqpqtqnfyeksnkrwaPMCVSAA.PGQSvVGAGQQVVA...P
  738-  763 (30.74/10.58)	NESG..............................QPGVIGGEN.RLANLQLPGglqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.73|      17|      21|    2339|    2355|      12
---------------------------------------------------------------------------
 2339- 2355 (32.57/13.41)	QQAQQQQ....QQGRLQIQML
 2357- 2377 (29.16/11.11)	QQAQQQQpvqaQSQWYKQQML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.29|      27|      50|     356|     384|      13
---------------------------------------------------------------------------
  356-  384 (49.24/28.79)	NMPTMGQ.......LGASNPYsyGSPNTVGPGAGVT
  404-  437 (42.05/18.44)	NMSPMQAaaaasrfTGAAGPI..GTTNVVGGQEGGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.52|      14|      48|    1670|    1683|      14
---------------------------------------------------------------------------
 1670- 1683 (26.20/16.31)	PKRLQEWYKKMLDK
 1686- 1699 (20.63/11.42)	VERIVLDYKDILKQ
 1720- 1732 (20.69/11.47)	PNVLEESIKE.LDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.41|      10|      56|     336|     345|      17
---------------------------------------------------------------------------
  336-  345 (20.16/10.46)	VGIVGPNQGG
  391-  400 (19.25/ 9.55)	VGVVKPQQKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.33|      20|      56|    1350|    1372|      18
---------------------------------------------------------------------------
 1350- 1369 (35.77/16.75)	YRYCTKLSEVFEQEIDPVMQ
 1379- 1398 (35.56/19.46)	YTFNPQVLCCYGKQLCTIPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.00|      16|      58|     590|     605|      19
---------------------------------------------------------------------------
  590-  605 (29.89/16.54)	QPNNQPNTSPSEMRRA
  640-  650 (18.26/ 6.20)	PPGALGN.....VRLA
  651-  666 (29.85/16.50)	QPQTQNFYEKSNKRWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.63|      26|      49|    1439|    1465|      22
---------------------------------------------------------------------------
 1439- 1465 (45.51/31.43)	KEQFQEMKNDHLELEPFvTCTDCG....RRV
 1488- 1517 (34.12/18.23)	KKKGQKRKENKFNAKRL.PVTKLGtyieTRV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08773 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANSLVMAAGTLGNKSPNMQSPPNVSVSKGGI
2) GAGQQVVAPNVSLPLNSDPSTVGVASNQTVPTTGPTSAAAAAAA
3) LLRRRMAVMNTRPTGPVAAMQAGQQTSNVGMTTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHINYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQPNTVMQQNPNLARQQTPQQLMQQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNP
4) LSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAK
5) MAAFIKQRALVHQQQPGQHGGGVGGPLGPNQPQQQPGLQHMMSQQQQPQQQQPQQQAQQQQQQGRLQIQMLTQQA
6) MADHLVDGPPPKRPKLDPFQGTSDSTVVGMPPLLMHPAYTNYGGGGSGNMQQIQAPTQQLHLQQHPLQHWNNNTVQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQLSHHLIQQQQGNKN
7) MGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMVGPARGQSPHQQVHQVGIVGPNQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTGAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGPQQATQGQMPGAGAPAGAKSTPDPEK
8) PGQGVGRGVRMPGPGMTGPPGALGNVRLAQPQTQNFY
9) QNTYTKRDLSNNVDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMAIQQHNRMQFPQQQQAQQQQQAQQQQQVQAQQQIQQQQQQQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGQPQMSQANLTTTTASNNATTSQFPTSNGTSAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQQQSQQQPQPTSTPSQVGTPATSIPQAPSPFSGMQQSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPVTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKVPEPIQPSGTSTDKKKCLFKPDE
10) RQQQVAQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
11) SSLANNQMSIANSMGGLQSSMSMAGSNPAMSMPGGMNSGLVMTSTASG
156
680
2046
1757
2285
1
254
622
855
2382
204
186
723
2282
1803
2359
153
489
658
1264
2586
251










Molecular Recognition Features






MoRF SequenceStartStop




1) RPIRPLLGYGGF
2420
2431