<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08767

Description XK-related protein
SequenceMHNINRERNNVTWVALALQAVWRSSMLISRFIVLLLALIFLKAWFFLFLGDNRHFPGLHWFIMTIWVILQKTKFCSTAWEERIYNCVIGLIYCFDFFNLRDDRSRYRVLIFYSVIAAQNVIFLIIYMLHVGETIAMIMIASVIVSCMLIGLTSMSLYYGKFHPSRTATNISRNISEHSTTTKVDASRSFKLFHRDSLVSLHHSMDISPRTEEVPTDKQSLLTNIAQISDCVEEGIVNRNYSSENEFNASALRLSTECERSHSRIGVKHKEEVTLVNDNPDNALTSSAPLNSLYSGLPDIDSSRKRRGIYEHDITPQLDWHAPDILNIDLNQLGSLDNSERSNSLTLDSCSKVIGALDVIKNREKLTTPTPLESSRIFDIEKQRDETMSCVTSIHDYENVCPLGIARPPWCIRSWKGYTDIETYIHDDSVVRDRRRDTLTSTTGTTYSSEYSDGMISRGILKQDDYADALTYDLVESKGNKSSYSDSTFSTSDDQNASLYIAKPVVFDDRGGMLALDTILEERDDLSSSDEKFQHGSELSRDSASTLVSTIDQIRRYTAENSPRHIYHTTGTHWEDLNPKNLMAQARFAKVLFDNDLRNASTTTGSIDLTARDVEKREIDAIREFVRCCAIESIKKTPLIDAVLSDSPILDKASKLMRQVTFADCKNDFDTNESDLYVEMSPLVSVENGENLCQARPIDTKTAEADESDTLKRNTLPTISKKSPNKENLSPSLSNNNRRINNIYDDKDNNDSHAWTIERDEKNDKSLCNMRFNLKEKRHLFLEQVLSPVPKLWNKLGQPSPGGGSASDKGKEWQMEFLMEKLRSKSSTYKPLVETAKNMRMAMLDKRFAIDSIEKNQLQKCLDTLQHSIKVTSFQSMVERLESLARQLGLKFMMSGPPGTEIFISSDMFFLEVLLEPPSGLVRDVKIHHEGKSEQQSCEALASALSHGDFVDFTTQLEGLASIYQLNADKKVKCKAFSALQSLEADLGILAQLQTFMKEPFNLVHKSPVGILERRRGGHPMKLTYFVSPYDLIDEENRTYDALNSDTIIKRKIGHSVTVCMEGSTGHKLPTSSIITVNRSPTGKSTPSYAPLTSTNSSMLPACFVLKLVKKMPICMELVKRIQKVTELECGDISAPHPLLSLIIQHASDGQLDCRNNRGLYVTLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNCLVASCVRPMARQDPEHTTILEVSALSWQHISVSVEHPYEETMATAELDLTDISMLKCRLYGMSMTTNVEQTSDLSGRVLQRCLSIPLTMRMLLKIWEGRSLPAVMNSLTSGSGSSNGSYNLNLGSGANSTSTSMLNPLQLGALLGQAKNSLTSNSNTNERGKKTRKRKTGTDGLWRSPKRKSDGGDNNTATEILLESSSSENSTPLGTPTSRENLAETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSSTEQQQQQQPQQEVEELIKMRESSSTRKSKKNRSSGGSEEKKSSPTNIFVDETSTTSNGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTPSPKTGSLTSATEDRQRSERKSGGGKSSSSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATCGKPVQSPKHSPVYGSTVSVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSKDSSGRGDKDRRTSSVSSSGGSGSGHQSPKTKSSSSKMKLEMISPGSEATQVSSLQASGGSTPPSGQVDAASKSAIAAQQARNRKSSLNAVIDKLKNAQHCTETDACGNGGGNVKGSGSSGLSSTGGMSSAGQKEKNIGGSGSSSSSGGKTIGEGGKSCVTKNASIDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSSSNVITGNNGSPKTHTGLKPGVNSGPASKKPQTLQATQKMLPTKMMLAAAGMKSAISSSGATNTGTGAGITASATGGVGGNPLSKSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQLDTKFQIPKLSARANVADADKNKSSDKLSILPDSTKQTLDGLKQEQSKIAGLSNITVSVSKSSQPDDQSRRDHSQNKPDNLSITTSAASAISLNLVGENTGLMLPPQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGMRQTSTGQQFLGKIDDTNVGGILSKSNVSDQLTSSGAKSYGTMTSSNTSTASSGAIVAESLNLSTKPADQAVLQTKYNKITVEEKKQQQTSSASLSSSSSSSSSSSSSLIFSSLASVATSSDAAAEMLLDFSAANKDSMTKGSHGLPVSLTQHHLTTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
Length2622
PositionMiddle
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.04
Grand average of hydropathy-0.503
Instability index55.11
Isoelectric point8.70
Molecular weight282024.33
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-UniRule
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08767
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1094.67|     188|     191|    1614|    1801|       2
---------------------------------------------------------------------------
 1360- 1451 (62.96/17.93)	............................................................................................................................................................L......TSNSNT..............NERG.............................KKTRK..RKTGTD.............GLWRSPKRKSDGGDNNTA........TEIllE....SSSSENST...PLGT...............................PT...SrE.NLAETRTSTP...TSATSLTSGMDFSN.....LDTTD.............
 1452- 1563 (131.13/46.33)	......IL.D.KSASDY.DLDNSEK.DS..EIMEVQ...HSS............................................................................................................................TEQ..............QQQQQPQ.QEVEE.........likmRESSSTRKSKKN..RSSGGS.............E....EKKSSPTNIFVDE........TST..T....SNGNK......GLPV...............................PP...S.V.SITP..................ISCGN.....LDQA..........STTN
 1564- 1730 (239.15/91.33)	YNSVLTGM.GlERRP................GIEIIPIASSP.....SQTNLPSSITITPI.......AGPTP............................................S.................................pktgsL......TSATED..............RQRSERK.SGGGK.............SSSSSSKSSSED..TKSGGS.............KLEKRRKRKREDGPMGPP........DKV..P....SGGKQQQD...PLSK...............................PV...S.V.SIKPSTEQSP...PSGGSAGVGLSCSS.....SRPTSPAAVRKFSPSPTH
 1731- 1926 (208.48/78.55)	SSSLATLV.G.KSSPTL.KAGQSAA.AT..CGKPVQSPKHSPVYG..STVSVPVPASASPK.......HGNTSS.....PKH...........................GSSAASSGK.................................psmsaL......KSAANSpssksssssssdsaTTPSKVK...................SSSS...SSSKD..SSGRGD.............K.DRRTSSVSSSGGSGSG........HQS..PktksSSSKMKLEmisPGSE...............................AT...Q.VsSLQASGGSTP...PSG...QVDAASKS.....AIAAQQARNRK.......
 1927- 2168 (166.56/61.09)	.SSLNAVI.D.K....L.KNAQHCT.ETdaCGNGGGNVKGSGSSGlsSTGGM...SSAGQK.......EKNIGG.......S...........................GSSSSSGGKtigeggkscvtknasidtknpgeymvkhssdgikitinK......TRTKDS..............KQAANLKlSSSGSmaatssssslssvASSSSSSSSSSNviTGNNGS...............PKTHTGLKPGVNSGPA........SKK..P....QTLQATQK...MLPT...............................KMmlaA.A.GMKSAISSSG...ATNTGTGAGITASAtggvgGNPLSKSSSSKASGSPKT
 2169- 2394 (118.29/40.98)	SSGVTDLSrG.RDKPRIsKSGDKGIfAS..KGLG.DARKSSP........SALREESESERafkllaaHASISNlppslPPQlmmeglmkqldtkfqipklsaranvadADKNKSSDK......................................LsilpdsTKQTLD............glKQEQSKI.AGLSN.............ITVSVSKSSQPD..DQS.........................RRDHSQNKP........DN....................LSIttsaasaislnlvgentglmlppqstadsdvPT...N.L.CIQPMVDNEP...SRDSCKDLGM..........RQTSTG..QQF......
 2395- 2600 (168.11/61.73)	.......L.G.KIDDTN.VGG.............ILS.......K..SNVSDQLTSSGAKS.......YGTMTS.......S...........................NTSTASSGA..............ivaeslnlstkpadqavlqtkynkI......TVEEKK..............QQQTSSA.SLSSS.............SSSSSSSSSSLI..FSSLASvatssdaaaemllDFSAANKDSMTKGSHGLPvsltqhhlTTI..P....ERAMTQAA...PTVR...............................RN...T.P.PPPPPPPPLPapfPPAASPSVSVHIVK.....SPAPSP...RVIPPSP.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.86|      50|     501|     769|     844|       3
---------------------------------------------------------------------------
  781-  844 (74.12/79.97)	LEQVLSpVP.......KLWNKLGQPSPGGGSASDKGkewqmeflmeklrSKSSTYK.PLVETAKNMRMAMLD
 1288- 1345 (76.75/34.92)	LQRCLS.IPltmrmllKIWEGRSLPAVMNSLTSGSG.............SSNGSYNlNLGSGANSTSTSMLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.96|      56|     501|     615|     675|       4
---------------------------------------------------------------------------
  615-  675 (78.01/75.95)	KReIDAIREfVRCCAIESikKTPLIDAVL...SDSPiLDKASKLMRQVTFADCKN.DFDTNESDL
 1119- 1178 (90.95/64.70)	KR.IQKVTE.LECGDISA..PHPLLSLIIqhaSDGQ.LDCRNNRGLYVTLPDQQHcYFMTENKNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.14|      42|     187|     167|     208|       5
---------------------------------------------------------------------------
  167-  208 (71.36/51.03)	ATNISRNISEHSTTTKVDASRSFKLF.HRD....SLVSLHHSMDISP
  355-  401 (63.78/44.61)	ALDVIKNREKLTTPTPLESSRIFDIEkQRDetmsCVTSIHDYENVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.09|      23|     801|     275|     297|      12
---------------------------------------------------------------------------
  275-  297 (43.01/22.73)	VNDNPDNALTSS.APLNSLYSG.LP
 1076- 1100 (34.08/16.22)	VNRSPTGKSTPSyAPLTSTNSSmLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08767 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQHCTETDACGNGGGNVKGSGSSGLSSTGGMSSAGQKEKNIGGSGSSSSSGGKTIGEGGKSCVTKNASIDTKNPGEYMVKHSSDGIKITINKTRTKDSKQAANLKLSSSGSMAATSSSSSLSSVASSSSSSSSSSNVITGNNGSPKTHTGLKPGVNSGPASKKPQTLQATQKMLPTKMMLAAAGMKSAISSSGATNTGTGAGITASATGGVGGNPLSKSSSSKASGSPKTSSGVTDLSRGRDKPRISKSGDKGIFASKGLGDARKSSPSALREESESERAFKLLAAHASISNLPPSLPPQLMMEGLMKQ
2) EMLLDFSAANKDSMTKGSHGLPVSLTQHHLTTIPERAMTQAAPTVRRNTPPPPPPPPPLPAPFPPAASPSVSVHIVKSPAPSPRVIPPSPHSSASPCITDDELMDEALVGMGK
3) LLGQAKNSLTSNSNTNERGKKTRKRKTGTDGLWRSPKRKSDGGDNNTATEILLESSSSENSTPLGTPTSRENLAETRTSTPTSATSLTSGMDFSNLDTTDILDKSASDYDLDNSEKDSEIMEVQHSSTEQQQQQQPQQEVEELIKMRESSSTRKSKKNRSSGGSEEKKSSPTNIFVDETSTTSNGNKGLPVPPSVSITPISCGNLDQASTTNYNSVLTGMGLERRPGIEIIPIASSPSQTNLPSSITITPIAGPTPSPKTGSLTSATEDRQRSERKSGGGKSSSSSSKSSSEDTKSGGSKLEKRRKRKREDGPMGPPDKVPSGGKQQQDPLSKPVSVSIKPSTEQSPPSGGSAGVGLSCSSSRPTSPAAVRKFSPSPTHSSSLATLVGKSSPTLKAGQSAAATCGKPVQSPKHSPVYGSTVSVPVPASASPKHGNTSSPKHGSSAASSGKPSMSALKSAANSPSSKSSSSSSSDSATTPSKVKSSSSSSSKDSSGRGDKDRRTSSVSSSGGSGSGHQSPKTKSSSSKMKLEMISPGSEATQVSSLQASGGSTPPSGQVDAASKSAIAAQQARNRKSSLNAVIDKL
4) LVGENTGLMLPPQSTADSDVPTNLCIQPMVDNEPSRDSCKDLGMRQTSTGQQFLGK
5) PKLSARANVADADKNKSSDKLSILPDSTKQTLDGLKQEQS
6) QARPIDTKTAEADESDTLKRNTLPTISKKSPNKENLSPSLSNNNRRINNIYDDK
7) SNITVSVSKSSQPDDQSRRDHSQNKPDNLSIT
1939
2510
1352
2342
2255
693
2300
2247
2622
1936
2397
2294
746
2331










Molecular Recognition Features






MoRF SequenceStartStop




1) LQATQKMLPTKMMLAA
2) RAFKLL
3) SSKMKLEMIS
2105
2217
1876
2120
2222
1885