<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08762

Description CREB-binding protein
SequenceMHPAYTNYGGGGSGNMQQIQAPSQQLHLQQHPLQHWNNNTIQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSIAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMIGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTSAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGAKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQVNGEMRQCTLPDCKTMKNVLNHMTNCQAGKTCTVPHCSMSRQIISHWKHCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRRAYEALGIQCPTTTPGILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQDFYEKSNKRWAPMCVSAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPVQGTKEWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMTIQQHNRMQFPQQAQQQQAQQQQVQAQQQIQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGPQMSQANLTTTTASNNATTSQFPTSNGTTAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQQSQQQPQPTNAPSQVGTPATSIPQTPSPFSGMQQPSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPTTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAMQTGQQTSNVAMSTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHSVSYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRQQPGQHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQSQQQQPQQQTQQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVAQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2503
PositionKinase
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.05
Grand average of hydropathy-0.727
Instability index59.26
Isoelectric point9.23
Molecular weight272391.03
Publications









Function






Annotated function

Acetyltransferase enzyme. Acetylates histones, giving a
specific tag for transcriptional activation.



GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08762
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     759.57|      58|      58|    1022|    1079|       1
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  919-  964 (52.34/ 9.82)	P............P........G..PSPNGQ...S..T.....SNA........NMVPNP..G.L.......S....PFG.........PQmS.QANLTTT.TA.SN....NATT......S
  965- 1019 (65.16/14.41)	Q...........FP........TSNGTTAGL...P..N.....SSP........IQNQHQFPD.LmkvrlaqA...QAQAA..Q.QQQQQQ.Q.QQQQQ............S.........Q
 1022- 1079 (106.27/29.14)	P...........QP........TNAPSQVGT...P..A.....TSI........PQTPSPFSG.M.......Q...QPSAQ..Q.PQQQPQ.Q.QSNQQFP.TR.PL....SATT.....PN
 1082- 1133 (55.39/10.91)	G...........IA........TSTPQTIPP...P..A.....SS...........GPSPTGG.V............PTTT..TgTTNGP....QSTTSTP.NT.PL....VPSL.....MT
 1134- 1192 (53.95/10.39)	P...........NQ........TVSSASNQT...P..P.....HSG........P.TPSP.AG.L.......A...SLGKEpiQ.PSGTST.D.KKKCLFK.PD.EL...rQALM.....PT
 2084- 2150 (60.16/12.62)	P...........LP........VQMPNPSGThliPmdQ.....WTAryqsntvmQQNP....N.L.......A...RQQTP..Q.QLMQQQ.Q.QQQHQAQ.PGmGM....GAQM......A
 2151- 2200 (57.31/11.60)	R...........QP........GVIG.PVGQ...V..G...................P.QAST.M.......H...KHALQ..Q.LMQTLR.S.PHTPDQQ.NQ.IL....QILK.....SN
 2201- 2276 (72.62/17.09)	PplmaafikqrqQP........GQHGGGVGG...P.lG.....PNQ........PQQQQP..G.L.......QhmmSQQQQ..S.QQQQPQ.Q.QTQQQQQ.QG.RL....QIQMltqqaQQ
 2277- 2335 (80.22/19.81)	Q...........QP........VQAQSQWYK...Q..Q.....MLV........MQQRQQQVA.Q.......Q...QQQQQ..Q.QQQQQQ.Q.QQQQQQPfTQ.PP....APPY.....GQ
 2336- 2399 (59.05/12.22)	Q...........RPirpllgygGFNEQGYGQ...P..G.lkptPPP........V..PSPQGV.M.......G...PPGIS......VQQQ.LmQSVRS.P.PP.IR....SPQ......PN
 2400- 2451 (54.03/10.42)	P.......................SPRPVPS...P..R.....NQP........V..PSPRSGpV.......P...SPHHH..P.PHGTPT.H.S.....P.AH.ELgggpSEMM.....LS
 2452- 2496 (43.09/ 6.50)	Q...........LG........GGPGAPTGH...P..AtmphhPSP..........APAPTNG...............GAD..A.NEVTP........MTP.QD.QL...............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     322.64|      50|      50|     251|     300|       2
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   78-  141 (33.22/ 6.82)	...............PPATGP...GPGQQNGaldtelRQHVQQQQQQlsHHLIQQQQGnknlvanslvmaagtlgnKSPNMQ
  142-  189 (39.70/ 9.74)	S.ppnVSVSKGGIvdPQMVVSLGNLPSSIAS.......SLANNQMSI..ANSMGGL....................QS....
  194-  238 (42.55/11.03)	................AGSNPAMSMPGGMNS......GLVMTSTASG..NNMGGMAGG.............slivtNSLNKQ
  250-  299 (93.76/34.15)	T....QAIHHPGA..PHGVTPMQNGPGMMNT......RAVAMQQQQQ..AHMIGPARG..................QSPHQQ
  300-  342 (61.88/19.76)	V....HQVGIVGP..GQGGPRMQAPPNMAN...........MPTMGQ..LGASNPYSY..................GSPN..
  409-  462 (51.53/15.08)	AqppaPS...PAQ..PQSGAPTGGQPGAKST...pdpEKCRLIQQQL..VLLLHAHKC..................QRRESQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     199.79|      35|      49|    1862|    1902|       3
---------------------------------------------------------------------------
  483-  503 (25.35/ 6.47)	NHMTNCQAGKtCTVPHCS.MSR...........................
  508-  529 (29.59/ 9.12)	.HWKHCNRSD.C..PVCLPIKQ.........ANKN..............
 1821- 1852 (46.76/21.46)	YHCTVCDDFDlC..VSC...KD.........KDGH...PHPMEKLgFDL
 1882- 1927 (47.26/25.47)	VHACQCRDAN.CRLPSCQKMKRvvmhtknckRKTNggcPI.CKQL.IAL
 1930- 1961 (50.84/22.37)	YHAKHCQETK.CLVPFCSNIKH.........KIKQ...QQLQQRL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.48|      31|     109|     585|     615|       4
---------------------------------------------------------------------------
  540-  582 (36.48/13.96)	.QPNNQPNTSPSE.MRrayealgiqcpttT........PGI....LPGQGVG.RGVRM
  583-  599 (26.89/ 7.70)	P....................................aPGM....AGPPGAL.GNVRL
  600-  642 (39.83/16.14)	AQPQTQDFYEKSN.KR.............WapmcvsaaPGQsvvgAGQQVVA.PNVSL
  668-  702 (26.29/ 7.31)	AAAAAANIQQSVNmQT.............L........FGL..neSGQPGVIgGENRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      15|      16|    1990|    2004|       5
---------------------------------------------------------------------------
 1990- 2004 (27.45/13.91)	TSNVAMS..TGVAMKPG
 2007- 2023 (23.05/10.13)	TSNLPTPhqPGIGLKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.95|      20|     105|     706|     736|       6
---------------------------------------------------------------------------
  706-  725 (34.73/12.40)	QLPGGLQPGQVTATPVQGTK
  812-  831 (33.23/11.71)	QLQAQQQQQQQQPTQPPGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      49|    1717|    1762|       7
---------------------------------------------------------------------------
 1717- 1761 (59.91/65.56)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1766- 1813 (59.49/39.89)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      10|      50|    1515|    1525|       9
---------------------------------------------------------------------------
 1515- 1525 (16.71/12.69)	CtPPNTRRVYI
 1568- 1577 (21.33/11.50)	C.PPSEGDDYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.93|      15|      21|     880|     894|      12
---------------------------------------------------------------------------
  880-  894 (29.45/11.02)	QQHNRMQFPQQAQQQ
  896-  910 (26.48/ 9.09)	AQQQQVQAQQQIQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.39|      13|      21|     732|     744|      13
---------------------------------------------------------------------------
  732-  744 (24.55/15.45)	TPDLRNHL...VHKLV
  750-  765 (20.83/11.69)	TPDPQAMLdkrMHNLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.77|      20|      21|    1280|    1299|      14
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 1206- 1223 (32.50/17.52)	FRQPVD..P..QALGIPDYPTI
 1224- 1242 (19.51/ 7.19)	VKKPMDlsTIKKKLD...TEKY
 1280- 1299 (38.76/22.49)	FEQEID..PVMQALGYCCGRKY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08762 with Med12 domain of Kingdom Metazoa
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