<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08762

Description CREB-binding protein
SequenceMHPAYTNYGGGGSGNMQQIQAPSQQLHLQQHPLQHWNNNTIQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQQLSHHLIQQQQGNKNLVANSLVMAAGTLGNKSPNMQSPPNVSVSKGGIVDPQMVVSLGNLPSSIASSLANNQMSIANSMGGLQSSMSIAGSNPAMSMPGGMNSGLVMTSTASGNNMGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMIGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTSAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGAKSTPDPEKCRLIQQQLVLLLHAHKCQRRESQVNGEMRQCTLPDCKTMKNVLNHMTNCQAGKTCTVPHCSMSRQIISHWKHCNRSDCPVCLPIKQANKNRTNSAQAPAIQPNNQPNTSPSEMRRAYEALGIQCPTTTPGILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQDFYEKSNKRWAPMCVSAAPGQSVVGAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAANIQQSVNMQTLFGLNESGQPGVIGGENRLANLQLPGGLQPGQVTATPVQGTKEWHLSVTPDLRNHLVHKLVQAIFPTPDPQAMLDKRMHNLVAYARKVEGDMYEMANSRSEYYHLLAEKIYKIQKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMTIQQHNRMQFPQQAQQQQAQQQQVQAQQQIQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGPQMSQANLTTTTASNNATTSQFPTSNGTTAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQQSQQQPQPTNAPSQVGTPATSIPQTPSPFSGMQQPSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPTTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKEPIQPSGTSTDKKKCLFKPDELRQALMPTLEKLYRQDPESIPFRQPVDPQALGIPDYPTIVKKPMDLSTIKKKLDTEKYSDPWEYVDDVWMMFDNAWLYNRKTSRVYRYCTKLSEVFEQEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNRYTFCQKCFNDIPGDTVTLGDDPTQPQTAIKKEQFQEMKNDHLELEPFVTCTDCGRRVHQICVLHMEAIWPLGFTCDNCLKKKGQKRKENKFNAKRLPVTKLGTYIETRVNNFLKKKEAGAGEVAIRVVASSDKVVEVKPGMRSRFVENGDMPGEFPYRAKALFAFEEVDGTDVCFFGMHVQEYGSECTPPNTRRVYIAYLDSVHFFRPRQFRTAVYHEILLGYLDYAKQLGYTMAHIWACPPSEGDDYIFHCHPAEQKIPKPKRLQEWYKKMLDKGMVERIVLDYKDILKQAMEDRLSSAADLPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAAANAIFSLSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAKIFATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPVINCDLMDGRDAFLTMARERHYEFSSLRRAKFSSMSMLYELHNQGQDKFVYTCNNCKSHVETRYHCTVCDDFDLCVSCKDKDGHPHPMEKLGFDLDDGSSPADAKQTNPQEARKLSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVMHTKNCKRKTNGGCPICKQLIALCCYHAKHCQETKCLVPFCSNIKHKIKQQQLQQRLQQAQLLRRRMAVMNTRPTGPVAMQTGQQTSNVAMSTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHSVSYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRQQPGQHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQSQQQQPQQQTQQQQQQGRLQIQMLTQQAQQQQPVQAQSQWYKQQMLVMQQRQQQVAQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
Length2503
PositionKinase
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.05
Grand average of hydropathy-0.727
Instability index59.26
Isoelectric point9.23
Molecular weight272391.03
Publications









Function






Annotated function

Acetyltransferase enzyme. Acetylates histones, giving a
specific tag for transcriptional activation.



ECO:0000256	ARBA:ARBA00002581

GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
histone acetyltransferase complex	GO:0000123	IEA:InterPro

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coactivator activity	GO:0003713	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08762
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     759.57|      58|      58|    1022|    1079|       1
---------------------------------------------------------------------------
  919-  964 (52.34/ 9.82)	P............P........G..PSPNGQ...S..T.....SNA........NMVPNP..G.L.......S....PFG.........PQmS.QANLTTT.TA.SN....NATT......S
  965- 1019 (65.16/14.41)	Q...........FP........TSNGTTAGL...P..N.....SSP........IQNQHQFPD.LmkvrlaqA...QAQAA..Q.QQQQQQ.Q.QQQQQ............S.........Q
 1022- 1079 (106.27/29.14)	P...........QP........TNAPSQVGT...P..A.....TSI........PQTPSPFSG.M.......Q...QPSAQ..Q.PQQQPQ.Q.QSNQQFP.TR.PL....SATT.....PN
 1082- 1133 (55.39/10.91)	G...........IA........TSTPQTIPP...P..A.....SS...........GPSPTGG.V............PTTT..TgTTNGP....QSTTSTP.NT.PL....VPSL.....MT
 1134- 1192 (53.95/10.39)	P...........NQ........TVSSASNQT...P..P.....HSG........P.TPSP.AG.L.......A...SLGKEpiQ.PSGTST.D.KKKCLFK.PD.EL...rQALM.....PT
 2084- 2150 (60.16/12.62)	P...........LP........VQMPNPSGThliPmdQ.....WTAryqsntvmQQNP....N.L.......A...RQQTP..Q.QLMQQQ.Q.QQQHQAQ.PGmGM....GAQM......A
 2151- 2200 (57.31/11.60)	R...........QP........GVIG.PVGQ...V..G...................P.QAST.M.......H...KHALQ..Q.LMQTLR.S.PHTPDQQ.NQ.IL....QILK.....SN
 2201- 2276 (72.62/17.09)	PplmaafikqrqQP........GQHGGGVGG...P.lG.....PNQ........PQQQQP..G.L.......QhmmSQQQQ..S.QQQQPQ.Q.QTQQQQQ.QG.RL....QIQMltqqaQQ
 2277- 2335 (80.22/19.81)	Q...........QP........VQAQSQWYK...Q..Q.....MLV........MQQRQQQVA.Q.......Q...QQQQQ..Q.QQQQQQ.Q.QQQQQQPfTQ.PP....APPY.....GQ
 2336- 2399 (59.05/12.22)	Q...........RPirpllgygGFNEQGYGQ...P..G.lkptPPP........V..PSPQGV.M.......G...PPGIS......VQQQ.LmQSVRS.P.PP.IR....SPQ......PN
 2400- 2451 (54.03/10.42)	P.......................SPRPVPS...P..R.....NQP........V..PSPRSGpV.......P...SPHHH..P.PHGTPT.H.S.....P.AH.ELgggpSEMM.....LS
 2452- 2496 (43.09/ 6.50)	Q...........LG........GGPGAPTGH...P..AtmphhPSP..........APAPTNG...............GAD..A.NEVTP........MTP.QD.QL...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     322.64|      50|      50|     251|     300|       2
---------------------------------------------------------------------------
   78-  141 (33.22/ 6.82)	...............PPATGP...GPGQQNGaldtelRQHVQQQQQQlsHHLIQQQQGnknlvanslvmaagtlgnKSPNMQ
  142-  189 (39.70/ 9.74)	S.ppnVSVSKGGIvdPQMVVSLGNLPSSIAS.......SLANNQMSI..ANSMGGL....................QS....
  194-  238 (42.55/11.03)	................AGSNPAMSMPGGMNS......GLVMTSTASG..NNMGGMAGG.............slivtNSLNKQ
  250-  299 (93.76/34.15)	T....QAIHHPGA..PHGVTPMQNGPGMMNT......RAVAMQQQQQ..AHMIGPARG..................QSPHQQ
  300-  342 (61.88/19.76)	V....HQVGIVGP..GQGGPRMQAPPNMAN...........MPTMGQ..LGASNPYSY..................GSPN..
  409-  462 (51.53/15.08)	AqppaPS...PAQ..PQSGAPTGGQPGAKST...pdpEKCRLIQQQL..VLLLHAHKC..................QRRESQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     199.79|      35|      49|    1862|    1902|       3
---------------------------------------------------------------------------
  483-  503 (25.35/ 6.47)	NHMTNCQAGKtCTVPHCS.MSR...........................
  508-  529 (29.59/ 9.12)	.HWKHCNRSD.C..PVCLPIKQ.........ANKN..............
 1821- 1852 (46.76/21.46)	YHCTVCDDFDlC..VSC...KD.........KDGH...PHPMEKLgFDL
 1882- 1927 (47.26/25.47)	VHACQCRDAN.CRLPSCQKMKRvvmhtknckRKTNggcPI.CKQL.IAL
 1930- 1961 (50.84/22.37)	YHAKHCQETK.CLVPFCSNIKH.........KIKQ...QQLQQRL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.48|      31|     109|     585|     615|       4
---------------------------------------------------------------------------
  540-  582 (36.48/13.96)	.QPNNQPNTSPSE.MRrayealgiqcpttT........PGI....LPGQGVG.RGVRM
  583-  599 (26.89/ 7.70)	P....................................aPGM....AGPPGAL.GNVRL
  600-  642 (39.83/16.14)	AQPQTQDFYEKSN.KR.............WapmcvsaaPGQsvvgAGQQVVA.PNVSL
  668-  702 (26.29/ 7.31)	AAAAAANIQQSVNmQT.............L........FGL..neSGQPGVIgGENRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      15|      16|    1990|    2004|       5
---------------------------------------------------------------------------
 1990- 2004 (27.45/13.91)	TSNVAMS..TGVAMKPG
 2007- 2023 (23.05/10.13)	TSNLPTPhqPGIGLKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.95|      20|     105|     706|     736|       6
---------------------------------------------------------------------------
  706-  725 (34.73/12.40)	QLPGGLQPGQVTATPVQGTK
  812-  831 (33.23/11.71)	QLQAQQQQQQQQPTQPPGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      40|      49|    1717|    1762|       7
---------------------------------------------------------------------------
 1717- 1761 (59.91/65.56)	GNDlsAkiFATM..EKHKEvFFVIRLHSAQSAASLAPI..QDPDPVI....NC
 1766- 1813 (59.49/39.89)	GRD..A..FLTMarERHYE.FSSLRRAKFSSMSMLYELhnQGQDKFVytcnNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      10|      50|    1515|    1525|       9
---------------------------------------------------------------------------
 1515- 1525 (16.71/12.69)	CtPPNTRRVYI
 1568- 1577 (21.33/11.50)	C.PPSEGDDYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.93|      15|      21|     880|     894|      12
---------------------------------------------------------------------------
  880-  894 (29.45/11.02)	QQHNRMQFPQQAQQQ
  896-  910 (26.48/ 9.09)	AQQQQVQAQQQIQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.39|      13|      21|     732|     744|      13
---------------------------------------------------------------------------
  732-  744 (24.55/15.45)	TPDLRNHL...VHKLV
  750-  765 (20.83/11.69)	TPDPQAMLdkrMHNLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.77|      20|      21|    1280|    1299|      14
---------------------------------------------------------------------------
 1206- 1223 (32.50/17.52)	FRQPVD..P..QALGIPDYPTI
 1224- 1242 (19.51/ 7.19)	VKKPMDlsTIKKKLD...TEKY
 1280- 1299 (38.76/22.49)	FEQEID..PVMQALGYCCGRKY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08762 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANSLVMAAGTLGNKSPNMQSPPNVSVSKGGI
2) GAGQQVVAPNVSLPLNSDPSTVGVAGNQTVPTTGPTSAAAAAAA
3) ILPGQGVGRGVRMPAPGMAGPPGALGNVRLAQPQTQDFY
4) LLRRRMAVMNTRPTGPVAMQTGQQTSNVAMSTGVAMKPGVSTSNLPTPHQPGIGLKPGTQTPPAHVLQVVKQVQEEAARQQAPHSVSYGKVTPGGGVGVGVGVGGQTGGVMPPPQMQRPLPVQMPNPSGTHLIPMDQWTARYQSNTVMQQNPNLARQQTPQQLMQQQQQQQHQAQPGMGMGAQMARQPGVIGPVGQVGPQASTMHKHALQQLMQTLRSPHTPDQQNQILQILKSNPPLMAAFIKQRQQPGQHGGGVGGPLGPNQPQQQQPGLQHMMSQQQQSQQQQPQQQTQQQQQQGRLQIQMLTQQA
5) LSEDAETPDGKKKGQKKAKKSNKSKANQRKNSKKSNTPQTGNDLSAK
6) MGGLQSSMSIAGSNPAMSMPGGMNSGLVMTSTASG
7) MGGMAGGSLIVTNSLNKQPLNTVTMMGPNTQAIHHPGAPHGVTPMQNGPGMMNTRAVAMQQQQQAHMIGPARGQSPHQQVHQVGIVGPGQGGPRMQAPPNMANMPTMGQLGASNPYSYGSPNTVGPGAGVTVCSNNPVGVVKPQQKGVGTNMSPMQAAAAASRFTSAAGPIGTTNVVGGQEGGTAAQQAQPPAPSPAQPQSGAPTGGQPGAKSTPDPEK
8) MHPAYTNYGGGGSGNMQQIQAPSQQLHLQQHPLQHWNNNTIQKRNYISNTEMFDLENDLPDDLLSSGSWGSTTESTKPPATGPGPGQQNGALDTELRQHVQQQQQQLSHHLIQQQQ
9) QKELDEKRQKRKEQQQLQAQQQQQQQQPTQPPGTSGPGLRPCAPPNVGTVMPGASKPVGTVPPTLRSHSPSMGQLATIPAMTIQQHNRMQFPQQAQQQQAQQQQVQAQQQIQQQQQQGILVGPPGPSPNGQSTSNANMVPNPGLSPFGPQMSQANLTTTTASNNATTSQFPTSNGTTAGLPNSSPIQNQHQFPDLMKVRLAQAQAQAAQQQQQQQQQQQQQSQQQPQPTNAPSQVGTPATSIPQTPSPFSGMQQPSAQQPQQQPQQQSNQQFPTRPLSATTPNDNGIATSTPQTIPPPASSGPSPTGGVPTTTTGTTNGPQSTTSTPNTPLVPSLMTPNQTVSSASNQTPPHSGPTPSPAGLASLGKEPIQPSGTSTDKKKCLFKPDE
10) RQQQVAQQQQQQQQQQQQQQQQQQQQQPFTQPPAPPYGQQRPIRPLLGYGGFNEQGYGQPGLKPTPPPVPSPQGVMGPPGISVQQQLMQSVRSPPPIRSPQPNPSPRPVPSPRNQPVPSPRSGPVPSPHHHPPHGTPTHSPAHELGGGPSEMMLSQLGGGPGAPTGHPATMPHHPSPAPAPTNGGADANEVTPMTPQDQLSKFVEGL
123
630
570
1966
1677
184
221
1
797
2297
153
673
608
2274
1723
218
439
116
1184
2503










Molecular Recognition Features






MoRF SequenceStartStop




1) RPIRPLLGYGGF
2337
2348