<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08758

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMGILYEKRPLKRPRLGPPDVYPQELKQKEDELSLTNVKHGFMATTTQLTDESGTGRNYNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVTLAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQDNGTGNNQPSTPTSSSQSVTGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKLAHMCNNVESNNNPQSPSITKNEVNVAFNDYLTCAHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLRIAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDKMDASNSLDTLYAKIFTPPPKDNSNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSTCSNGSPPVLPIFQPLLMKFLDMDAPVLDNTSNQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKILQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRIRDEARHVVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYIVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRAALYSTLQPTPSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEVEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDATAAKQPPKKVDIPLSHSTKGGAMSSSSSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTPRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFTPSSNELSQWLDTVAKAAIDVFQLNNTLSNKSDKKSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNAELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSSSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKELEPGKADTPMSIDSPGRVGGSVGSTGVGNVNTNGKGKAMRNKRHNRRAKGAATPTTPISQQMQQPPQLQQIAFGNQQAPVAQQPGMFTGQPPQPQQQWYSNQQTHTPAQQYGYSQQLPPTPVGGPRYERPGMNNQSKQALSNMLRLRLPSNQFMGSQQQPPTATPVAGPGAFQGMQRQFIRQQLRAQHGAPGINPQQGMFAAQQQQQQQQQQQQGIYAGIQQGMNQNYAGYGGQQMMQQQQQQQQQTSQQTQQQQQQQLLQQQQQQQQQQQQQGILNQQQSMMFPNQQQMMGPQRGQEYIPQQRMQPSAARPPYLQAPNVTMNAMGPMGAGVQNQPAPPYRQSAGKPGAVGVTGVGTANVSLQQNQQFQQQQAINQRMRQQMLAMQQQQQQAQQQQAAQQQQQQQQGAAGGQQPTPQLVTHLQRHLSQPPQHSYQHQPPPY
Length2152
PositionKinase
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.06
Grand average of hydropathy-0.522
Instability index51.69
Isoelectric point8.00
Molecular weight240364.97
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08758
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     207.08|      21|      21|    1945|    1965|       1
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 1787- 1806 (26.90/ 8.31)	QQ.APVA...QQPGMFTGQPP.QPQ
 1862- 1882 (26.44/ 8.03)	NQFMGSQ...QQPPTATPVAG.PGA
 1883- 1906 (24.91/ 7.06)	FQGMQRQfirQQLRAQHGAPG.INP
 1945- 1965 (42.55/18.13)	QQMMQQQ...QQQQQQTSQQT.QQQ
 1968- 1989 (32.41/11.77)	QQLLQQQ...QQQQQQQQQQGiLNQ
 1990- 2010 (30.06/10.29)	QQSMMFP...NQQQMMGPQRG.QEY
 2110- 2125 (23.81/ 6.38)	.....QQ...QQQQQQGAAGG.QQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.83|      17|     180|    1907|    1924|       2
---------------------------------------------------------------------------
 1907- 1924 (30.67/13.75)	QQgMFAAQQQQQQQQQQQ
 2091- 2107 (35.16/12.52)	QQ.MLAMQQQQQQAQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      15|      15|     272|     286|       3
---------------------------------------------------------------------------
  272-  286 (25.11/15.33)	EDGILKLLLPLALQY
  288-  302 (24.90/15.13)	EEFIQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.17|      30|      39|      88|     126|       4
---------------------------------------------------------------------------
   88-  117 (53.90/41.13)	KRQQINPKDNFWPVTARTKNGI..EAWFKDLS
  128-  159 (49.27/22.54)	KAPNFNKKEEIFMMLCEYQVPMlrAAWFIKLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.47|      27|      45|    1377|    1403|       5
---------------------------------------------------------------------------
 1377- 1403 (44.65/31.56)	NKSDKKSGSIWLVAPLVSKLPSAVQGR
 1424- 1450 (46.82/33.53)	ERGRSKSPSLFNHQPFLSLVLTCLKGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      19|    1021|    1036|       8
---------------------------------------------------------------------------
 1021- 1036 (27.65/16.53)	CNAIVAVCSETDNDKL
 1043- 1058 (30.04/18.61)	CAELTACCNALNAEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.66|      16|      19|    2028|    2043|      10
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 2028- 2043 (30.28/14.48)	APNVTMNAMGPMGAGV
 2048- 2063 (28.38/13.15)	APPYRQSAGKPGAVGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      13|      15|    1263|    1275|      11
---------------------------------------------------------------------------
 1263- 1275 (25.43/20.78)	QICSQEWVLERCL
 1280- 1292 (23.36/18.25)	ELCHQDMLLDNML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.46|      11|      15|    1687|    1697|      12
---------------------------------------------------------------------------
 1687- 1697 (20.52/12.42)	QIRPASHYLDP
 1704- 1714 (18.94/10.81)	DLEPDKKELEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      17|      20|     449|     465|      13
---------------------------------------------------------------------------
  449-  465 (29.69/23.46)	LDALDRHSFDKMDASNS
  466-  482 (31.04/24.98)	LDTLYAKIFTPPPKDNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.04|      10|      20|    1160|    1169|      14
---------------------------------------------------------------------------
 1160- 1169 (19.88/12.45)	YSV..STSPHPL
 1177- 1188 (15.16/ 7.38)	YSIklSCDRHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.78|      10|      20|    1069|    1078|      15
---------------------------------------------------------------------------
 1069- 1078 (17.40/ 9.85)	NSSAFYIDVL
 1090- 1099 (16.39/ 8.88)	NSLAIFTSIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.81|      15|      21|    1499|    1513|      21
---------------------------------------------------------------------------
 1499- 1513 (25.87/17.73)	LVGGV.FDTIQRNTTA
 1521- 1536 (20.94/12.84)	LVQLVsYGVIDLNNNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.10|      14|     126|    2012|    2025|      25
---------------------------------------------------------------------------
 1818- 1831 (25.74/12.01)	PAQQYGYSQQLPPT
 2012- 2025 (28.78/14.49)	PQQRMQPSAARPPY
 2141- 2152 (26.57/12.69)	PQHSYQHQP..PPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08758 with Med12 domain of Kingdom Metazoa
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