<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08757

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMIENRTGPQTIEFLTKRVVALGAVQVGQFLVDCETYMSVPQLGVQRTVHVLHNSEQPASVFALLESGSKVVPLIADGLFDLLMMKMTTIYTSKKQTKIESKGPRFEIGDFCVKLGSVTMSQNFKGVLVEVEYRPCVVPASAWELIREFLQGFLGSTVSNQAPQYLQVNIYFFKINFVNANTTIGEVKQELYKLKKAANVNRQSLRLDAKGKSLSDSETIKSLSLKTGGKLYYKDLGPQIGWKTVFLLEYAGPLVMYLWLYQRPWLFYGNVDTSNFHYIAKCAAGAWSIHYVKRLLETIFVHRFSHATMPLRNLFKNCSYYWLFAMYVAYHTNHPLYTAPSKFQFHIGSIIFVLCELGNLSIHLALRNLRPSGTTVRKVPMPTKNPFTALFLLVSCPNYTYEIGSWIGFTVMTSCLPAGLFTLAGAYQMTVWALGKHKAYKKEFSHYPKNRKAIIPNIKLSNYDKHVINNSVNF
Length473
PositionHead
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.13
Grand average of hydropathy0.024
Instability index39.26
Isoelectric point9.55
Molecular weight53675.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
endoplasmic reticulum membrane	GO:0005789	IEA:UniProtKB-SubCell
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
oxidoreductase activity, acting on the CH-CH group of donors	GO:0016627	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
lipid metabolic process	GO:0006629	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08757
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.73|      41|      54|     308|     350|       1
---------------------------------------------------------------------------
  264-  289 (39.99/18.84)	.............WLF..YGNVDTSNF......HYIA..KCAAGAWSIH
  308-  350 (74.66/48.22)	MPLRNLFKNCSyyWLFAMYVAYHTNHP......LYTAPSKFQFHIGSII
  363-  406 (61.08/32.98)	LALRNLRPSGT....TVRKVPMPTKNPftalflLVSCPN.YTYEIGSWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.01|      10|      15|     202|     211|       2
---------------------------------------------------------------------------
  202-  211 (17.09/10.20)	QSLRLDAKGK
  220-  229 (16.92/10.03)	KSLSLKTGGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08757 with Med20 domain of Kingdom Metazoa
Unable to open file!