<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08752

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMATDDSWKTPHFRQSVVAKIDEAIQVSGMPTTKNSIEMENHVFQKAKSKEEYLGFVARLILHVREMNSKKSATGNAPGISTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPLNMPGIQNKMPGMGMMPSQTGGSMNHMGPIQSMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQINNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKSSEMINTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSIGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYIEPLRRMIAKMSNEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRGDGSVGPPVTTLKEHQIFSPLLEAVSAHLQSPVINHTLQRTFGPCLDALFGPEIKNLPPPLKKQKIEESSSEIPDVLQGEIARLDQRFKVSLDPAQQSGSRCIQLICWLDDRHLPCVPPISVTVPADYPSTPPRCVMAPHEYEATTFLCAVQKALNIRIAKLPRRFSLSQLLDTWEMSVRQASAPKEMSITASTVLMGL
Length635
PositionTail
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.03
Grand average of hydropathy-0.467
Instability index59.04
Isoelectric point9.39
Molecular weight68923.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08752
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.06|      22|      22|     283|     304|       2
---------------------------------------------------------------------------
  102-  118 (24.60/ 6.92)	.QGTGNN..QMM....S..MGGPNHQ
  125-  148 (29.59/ 9.91)	PTNTATNllQSLNQRPA..QPLNMPG
  283-  304 (39.94/16.12)	PRNVTPN..QFLRQSPS..PSAPSPA
  306-  327 (26.85/ 8.27)	LGAPSSN..QMV.ASPAlvPS.PSPQ
  334-  355 (34.08/12.60)	PTRSVNS..IGMAPSPS..SSLNTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.77|      15|      16|     221|     235|       3
---------------------------------------------------------------------------
  159-  171 (23.01/ 8.32)	MPSQTGGSMNHM..G
  221-  235 (29.27/12.80)	MQTQLPGQINNQITG
  268-  282 (20.49/ 6.52)	IQRKSSEMINTGFPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.10|      20|      20|     391|     410|       4
---------------------------------------------------------------------------
  391-  410 (31.93/23.87)	MSNEGNVDKLSKMKKLLEIL
  413-  432 (32.17/24.11)	PSKRMPLDTLLKCEVVLEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.22|      10|      20|     236|     250|       5
---------------------------------------------------------------------------
  236-  250 (10.91/14.32)	PmGNIQtsisQQMNQ
  258-  267 (21.31/ 8.32)	P.GQMQ....QQLNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.91|      17|      22|     444|     465|       6
---------------------------------------------------------------------------
  444-  460 (29.57/28.08)	PVTTLKEHQIFSPLLEA
  468-  484 (32.34/16.98)	PVINHTLQRTFGPCLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.28|      20|      22|     583|     604|       7
---------------------------------------------------------------------------
  583-  604 (28.83/29.46)	FLCAVQkaLNIRIAKLPRRFSL
  607-  626 (34.46/27.14)	LLDTWE..MSVRQASAPKEMSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.36|      10|      30|     530|     539|       8
---------------------------------------------------------------------------
  530-  539 (19.62/ 9.23)	PAQQSGS..RCI
  561-  572 (15.74/ 6.16)	PADYPSTppRCV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08752 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNSKKSATGNAPGISTAGTNNQGMPDPIGALQTLARQGTGNNQMMSMGGPNHQGIISQPPTNTATNLLQSLNQRPAQPLNMPGIQNKMPGMGMMPSQTGGSMNHMGPIQSMQNNPMLTQMNQMGQGNIPPQMNQMVPGQMGQLGAGQMQQNMQSQMQTQLPGQINNQITGPMGNIQTSISQQMNQIGPGQLGPGQMQQQLNHIQRKSSEMINTGFPGPRNVTPNQFLRQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSPQHAIMTGPTRSVNSIGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
66
376










Molecular Recognition Features






MoRF SequenceStartStop




NANANA