<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08746

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSSETQITNILNDILKVEAIEEAFSCVLVHHPKKETDKVAAWHQELRTAMTGLTKEQQEAAVRQFLSIAAAMTNHRRLQLLLSLLENLVHSNFLPARLVCECILSCDKLQYQLEDFWVECFVLIKHILGGVDYKGVREIMKGCKEKAQTIPARLDASVQPQLKALENVIEFIFDRNACLLPGYFIVNEIQKAYPDGKNWPHWKLAKLLSDFVESFRHTAQMVSIVGHSKMLPVVEHTGYADYLINPWLLDPTTLKFSLKGNLPYDPDLLKPQTELLRYVLEQPYSRDMVCSMLGLQKQHKQRCVVLEEQLVELVILAMERSENETLPAEGMDGTVANHWVWLHLSSQLIYFILFQFACFPSIVMAIHDKLAGRELRKGRDHLMWVLLQFISGSIQRNPLSNFLPVLKLYDLLYPEKEPLPVPDYTQALCTHQMAITCIWIHLLKKAQTEPGTNIHRPIPHTLKVHHEFLQHLVMPNASLCMGSDYRIALLCNAYSTNQEYFSRPMAALVDTILGTQKNQQQQPLQNLQNNAALANGPTTPLSMSILDSLTVHSKMSLIHSIVTHVIKLAQSKSNMALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSHAWGTLYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRALVLTLARSMHVTGTGADSLSGTWCKELLNTIMQNTPHSWANHTLQCFPPVLSEFFQQNSVAKENKQQIKKAVEEEYRNWASMNNENDIIAHFSVPGTPPLFLCLLWKMILETDRISPIAYKILERIGARALSAHLRKFCDYLVFEFANSVGGQHVNKCVDTINDMIWKYNIVTIDRLVLCLALRTQEGNEAQVCFFIIQLLLLKAAEFRNRVQEFVKENSPEHWKQSNWHEKHLAFHRKFPEKFAPEGIMEQTSGGPSQYQNLPVYFGNVCLRFLPVFDIVVHRYLEIPPVIKSLEILLEHLGCLYKFHDRPVTYLYNTLHYYEKKLRDRPLLKRRLVSAVLGSLREIRAPGWALSEAYQMYMTRFNDDAVSWVPELDYYIRLVQRIVETMSGTAHFPATDWRFNEFPNPAAHALYVTCVELMALPVAPDAVANFLLDVVAKGYTVVPSDEIHLWINCVGLLLAALPECYWSALHKRLLETISSPGLVNWQYNNLTPFQMFNFNITHNSLLENKYSYMLALAHSVWHHAGVGQITTMPQFIKEKLQPVVSSEEQLIYACHLIGPTLARFNAERPHCVVELAVCLYEMLERVDHTQTTLNYMDSICDLLVSYFLMLCLSFYESFYIFLNNSDRYHIKYMFVGDMTKNEVECIIRRLRPALQMRLRFIAHINIDEIHTS
Length1381
PositionTail
OrganismAtta colombica
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Myrmicinae> Atta.
Aromaticity0.10
Grand average of hydropathy-0.024
Instability index46.57
Isoelectric point6.68
Molecular weight158499.29
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08746
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.73|      34|     148|     454|     495|       1
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  454-  495 (56.85/47.95)	IHRPIPHTLKVH...........HEFLQHLVMPNaslcmgsdYRIALLCNAYS
  603-  647 (54.88/30.57)	ISQLLPTVFKSHawgtlytllemFSYRMHHIQPH........YRVQLLSHLHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     465.71|     162|     260|     799|    1016|       2
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  799- 1004 (234.45/232.04)	PGTPplfLCLLWKMIL...ETDRIS..P.IAY..KILERIgARALS..AHLrKFCDYLVFEFANSVGGQHVNKCVDTINDMIWK..............YNIVTIDRLVL...ClalrtqegneaqvcffiIQLLLLKAAE.....FRNRVQEFVkeNSPehwKQSNWHEKHLAFHRKFPEKFAPEGIME.QTS............GGPSQyqnlpvyfgnvcLRFLPVFdivVHRYLEipPVIKSLEILLE
 1055- 1261 (231.25/147.88)	PGWA...LSEAYQMYMtrfNDDAVSwvPeLDYyiRLVQRI.VETMSgtAHF.PATDWRFNEFPNPAAHALYVTCVELMALPVAPdavanflldvvakgYTVVPSDEIHLwinC.................VGLLLAALPEcywsaLHKRLLETI..SSP...GLVNWQYNNLTPFQMFNFNITHNSLLEnKYSymlalahsvwhhAGVGQ............ITTMPQF...IKEKLQ..PVVSSEEQLIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.96|      68|     260|       8|     132|       3
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   52-  120 (115.50/141.67)	GLTKEQQEAAVrQFLSIAAAMTNHRRLQLLLSLLENL.VHSNF.LPARLVCECI.LSCDKLQYQLEDFWVEC
  514-  584 (103.46/51.19)	GTQKNQQQQPL.QNLQNNAALANGPTTPLSMSILDSLtVHSKMsLIHSIVTHVIkLAQSKSNMALAPALVET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.39|      31|     277|     387|     419|       4
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  254-  276 (33.94/19.44)	LKFsLKGNLPYDP............DLLKPQTELL
  387-  419 (51.48/41.03)	LQF.ISGSIQRNP.LSNFLPVLKlyDLLYPEKEPL
  675-  701 (31.98/17.84)	......GSAEVQPqLSRFLSEPK..TLVSAESEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.12|      20|     277|    1008|    1028|       5
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 1008- 1028 (35.67/28.49)	CLYKFHDRpVTYLYNTLHYYE
 1287- 1306 (38.45/24.87)	CLYEMLER.VDHTQTTLNYMD
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.69|      60|     135|     187|     249|       7
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  187-  249 (102.06/67.84)	NEIQKAYP.DGKNWPHWKLAKLLSDFVE.SFRHTAQMVSIVG..HSKMLPVVEHTGYaDYLInpWLL
  323-  386 (97.63/55.30)	NETLPAEGmDGTVANHWVWLHLSSQLIYfILFQFACFPSIVMaiHDKLAGRELRKGR.DHLM..WVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.36|      45|     583|     126|     176|       8
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  126-  176 (72.63/58.65)	HILG.GVDYkgvreiMKG..CKEKAQTIPARLDAS.VQPQLKALENVIEFIFDRN
  714-  762 (69.73/44.04)	HVTGtGADS......LSGtwCKELLNTIMQNTPHSwANHTLQCFPPVLSEFFQQN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08746 with Med23 domain of Kingdom Metazoa
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