<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08734

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDHGSRNGSHTNHDRDERHNGVNGIIYTSEKTQDKGKGRVEPQQNMTPISPTMPNGINGTFSDDPQHANGAGNGHDMQNRVDQLPPEILHITQGYMPLSGLLSRLAQHSNTALQATLTELAQMPLPASMTNGNTSHSSSTDDNSPENQAKKKRLLDFATNTHESWTKALVVTGWSRKADEVSRAVDIKVHVDQEKAFYTACIDELAFRRRSFSTDPKKRWPNPDLKTAVPVLTTGKAHWMPDLGYISQPPLTSKDVLQSLEKLNTLLSARLNLDDYDSIPLQFKDFTIKSGRATFKVEGEFELDVTIADEEPQSQFWFIDFRFLFWPSASILTPRARTFIESRVNEILLRDGLSGCYKFLHEMILTYKISEFRHQAIDLGRAKWVETLKVEALNRALSVQYWLDRYNGSGTKSWIILGVHSGKREDGRPDANSTSRLSLRWFRDHKEVKDADISFDTVNISTESLLRVVIAMHISHILTVIFDKLSAHTLYANRELGISLVTSPDDPSKPELEVSLTNERRLSLKIDPISGRFVFSPTMLMAHKYEVMMNAPSRDPKDSTGKRMEDTIDKALRVLENLRYSFITDDIVTRGVSLGWRRLPDPGIKRSVLFESIPKNTQMSLWLRRPGWAEDWYLLVCLSMSGANWFLIKLMRQATPLDPNPNALGIGPFLKVQIKTVSPTINYMFLTALNIYTGGLLSYYANLKTLHAKRVRQMLRQGPPSRSLTLPVIFVKISELLRDSPTMMNSKAFWAKKDVIKLTYKGVEVHAPSPNDINALSQTSITATQSSNATLIRRPTIMEEKAVLVTEARMIVPLPKNLAILNEKVDPDIAFHPTTGSFALRLYSKIGESVIPELIERITGIGRLVQFVDVLQKHEKTLKCESVSLGKIVFKYGQASSTQSDPSPATRPSLQYSATVDFSTGENTMTLILEKANPHLRIKNFLTNVLNSAEGLNGVATLLTLTLPLLRGLTAIEEAWNDSALYEKGEAFVTARATDWYNIRYNLRQPAAQNQTTPPRLRRVLFDLRLRQRRGEPWWHLHRTDNLRLKDWDNLDTALKPLWTTSGPGWRAMMSSAAGQGNGIEELLAKMDDVVRTFAMSDVGIQSQQAADVPAPIPKQAPTQAPPSRQPQQQRQQPTPSQSQSQSQDRGNPRHKVIEID
Length1162
PositionTail
OrganismPhialocephala scopiformis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index48.57
Isoelectric point9.22
Molecular weight130751.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08734
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.42|      71|     124|     939|    1020|       1
---------------------------------------------------------------------------
  939- 1020 (111.32/94.84)	PHLRiknfltNVLNSAEGL.NGVATLLTLTLPLLRGLtaieeAWNDSALYEKGEAFVTARATDWYNIRY.NLRQPAAQNQTTPP
 1069- 1141 (118.10/77.20)	PGWR......AMMSSAAGQgNGIEELLAKMDDVVRTF.....AMSDVGIQSQQAADVPAPIPKQAPTQApPSRQPQQQRQQPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     765.24|     252|     363|     110|     389|       2
---------------------------------------------------------------------------
  110-  389 (375.74/264.94)	LAQHSNTALQATLTELAQMPLPASMTNGNTSHSSSTDDNSPE...NQAKKKRL...LDFATNTHESWTKALVVTGWSRKADEVSRavDIKvhvDQEKAFYTACIDElAFR.....RRSFSTDpkkrwpnpDlktavpVLTTG.KAHW..MPDLGyISQPPL...TSKDVLQSL........EKLNTLLSARLNLDDYDSIPLQFKDFTIKSGRATFKVeGEFeLDVTIADEEPQSQFWFIDFRFLFwpSASILTPRA..RTFIESRVNEiLLRDGLSGcyKFLHEMILTYKISEFRHQAIDL..GRAKW
  475-  755 (389.50/210.82)	IAMHISHILTVIFDKLSAHTLYANRELGISLVTSPDDPSKPElevSLTNERRLslkIDPISGRFVFSPTMLMAHKYEVMMNAPSR..DPK...DSTGKRMEDTIDK.ALRvlenlRYSFITD........D......IVTRGvSLGWrrLPDPG.IKRSVLfesIPKNTQMSLwlrrpgwaEDWYLLVCLSMSGANWFLIKLMRQATPLDPNPNALGI.GPF.LKVQIKTVSPTINYMFLTALNIY..TGGLLSYYAnlKTLHAKRVRQ.MLRQGPPS..RSLTLPVIFVKISELLRDSPTMmnSKAFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.94|      25|      32|      25|      50|       3
---------------------------------------------------------------------------
   25-   50 (40.25/38.11)	NGVNGiIYTSEKTQDKGKGRVEPQQN
   60-   84 (47.69/39.55)	NGING.TFSDDPQHANGAGNGHDMQN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08734 with Med14 domain of Kingdom Fungi
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