<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08732

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYLTNVLSSNEFASIKYEYFELHNLSTWSARRSLQRVEAVWRQEGKLAYCDPYRDGLWVFERSSNPASDYQVKEGELLSPGVVEVQGIALVQRDRGIYEPASLARSKSAIPNAVNTPTSSASPSSSQDNALRNTQALNARSTQTNALLNVNQEPPTPSPGIKSERTPSQKDVHEYFVSAVLGSVAYLLVRESGLVPLNSRTLILNASKSLRPSLLKSGNTSCNTIELATLDVSLTSLGSLVVKAITDPAPGLQALVSRSSLLDWAEQVTSGTALWLAPSGIAARFHSLPDEDRHPSTSSIARLQDSPGTQRNSGFNSLSVKSWQSKCLEWLSVKGLDPILLEAGGWVFVQVHGGQSPYSTSDYESNPMLEDLTVVPWPALLCFQPSNSRNLDHESRKGTDSASRDPISFSEEWFKGRDERASVSNKRLKERQIAEAQSSEQAAVDARAMQSHLYSPVALRRGSNAGAMYPTPPDAPHQIVGATPTFDGTVSTPGNQHPNAQVDTGQPPQTSNDVDTEMWSSGKKEQAPATTHYHEHEADNDNLFGDLGGDLLFGNDITDADFSFFDQPDEVGFDQKQASPTPVGPPVSKENIPSDTGLVGDNSHAELSPKPDLSEPEPSPAAVESNQIDSIMENADGAFIPDTPKDARIDTSTKLPSSTANAPFDKEAVFKLLVKAHSDDQAHGQPRRTSQFNKIDFETSLQAVNEKYDSNGLFSFKLPKSRPHEDFSQLPQTKYLNGRRKTQDRTSEMGHIARILMERSSLNQPATDEPMDYLVDTNFASPISEQDDSSHTTDNPTLPQRVGMKRKWEESNGDEITSSFDALAMDLERSVSTPQSATGSQLPLLDADPADWSLTTYFTSVEPDVQSTILSDHERIATAQILADQAVSATLKFPGVPGSELVQHKASSTRKLIQKLVKTTKCCLKEINPCTMRALIDIQGIPVLSQGLRLAQRPMPNPRGPNNVDGTRSNNPFAIPPPQLEIRRSDSKLSILPAAISFWENLGLGPAKGAKDVSAVCIWPSFSGVQANANTFLDQMRSIYESSRLGNHDRLVTKDLHNGLLPFAVDLQQQNRVQQMASLRDMTGKLSKVLSALAVEEKNLVVYFVYPPDNNALLVQICSAFQHLFNLYRKSLSEKKINVSNELVLQLIPLDFISSSTSIAVPLPSQYFRLALEVYDRCVDFASSSSSPAIMLEQPLPRNIDFKLNANPSASLLQENTCLHVAYAQSIDDRWITAAWTDNRGTQQMTASYCLGRKNEPISTAFSVIAHEIWETTLDFISSKKIHWRIMIARVGVMDPSEIDFWTGLAATESDAQISITLITVQTDPSLRLLPAPVTIGPNGNSTNSNVTPVSTPQAFQPSVVSPDNAPTPVRENTYSAAAVEGQPEPDSDARLIDYTDQNWGIVLSHRLNNSNSLMELNLALISGYLVKRGGTNSDDPPIVMEVNVVHSEVLGNPRTFHESLLREILGYYRGLGTLARVRGMVDAVRDVRPWHIAAAEKAVKALYMLM
Length1511
PositionKinase
OrganismPhialocephala scopiformis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala.
Aromaticity0.07
Grand average of hydropathy-0.407
Instability index43.64
Isoelectric point5.25
Molecular weight165612.41
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.36|      20|      28|     867|     894|       1
---------------------------------------------------------------------------
  867-  886 (32.29/30.61)	PDVQSTILSDHERIATAQIL
  898-  917 (33.08/14.04)	PGVPGSELVQHKASSTRKLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.52|      36|     519|     816|     861|       2
---------------------------------------------------------------------------
  816-  861 (53.89/44.72)	NGDEITSSFdalamdleRSVSTPQSATGSQL.PllDADPADWSLTTY
 1343- 1379 (62.64/31.94)	NGNSTNSNV........TPVSTPQAFQPSVVsP..DNAPTPVRENTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.71|      31|     520|     932|     979|       3
---------------------------------------------------------------------------
   85-  118 (47.82/17.24)	GV.VEVQGIALVQR....DRGiyePASLARSKSAIPNAV
  944-  979 (46.89/30.52)	GIpVLSQGLRLAQRpmpnPRG...PNNVDGTRSNNPFAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.75|      21|     286|      60|      80|       4
---------------------------------------------------------------------------
   60-   80 (38.70/24.76)	GLWVFERSSNPASDYQVKEGE
  348-  368 (41.05/26.76)	GGWVFVQVHGGQSPYSTSDYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.34|      17|      24|     616|     639|       5
---------------------------------------------------------------------------
  603-  619 (25.34/ 6.45)	VGDNSHAELSPKPDLSE
  627-  643 (27.00/23.96)	VESNQIDSIMENADGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      11|      27|    1155|    1165|      13
---------------------------------------------------------------------------
 1155- 1165 (19.79/10.94)	DFISSSTSIAV
 1184- 1194 (20.58/11.71)	DFASSSSSPAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08732 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FKLLVKAHSDDQAHGQPRRTSQFNKIDFETSL
2) ITDADFSFFDQPDEVGFDQKQASPTPVGPPVSKENIPSDTGLVGDNSHAELSPKPDLSEPEPSPAAVESNQIDSIMENADGAFIPDTPKDARIDTSTKLPSSTAN
3) LPKSRPHEDFSQLPQTKYLNGRRKTQDRTSEMGHIARILMERSSLNQPATDEPMDYLVDTNFASPISEQDDSSHTTDNPTLPQRVGMKRKWEES
4) PNGNSTNSNVTPVSTPQAFQPSVVSPDNAPTPVRENTYSAAAVEGQ
5) RLAQRPMPNPRGPNNVDGTRSNNPFAIPPPQ
6) SAIPNAVNTPTSSASPSSSQDNALRNTQALN
7) SNKRLKERQIAEAQSSEQAAVDARAMQSHLYSPVALRRGSNAGAMYPTPPDAPHQIVGATPTFDGTVSTPGNQHPNAQVDTGQPPQTSNDVDTEMWSSGKKEQAPATTHYHEHEADNDNLFGDLGGDL
674
561
722
1342
953
112
428
705
665
815
1387
983
142
555










Molecular Recognition Features






MoRF SequenceStartStop




NANANA