<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08719

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSSRPPMGVPQRQPPSRSLSSSNTLSQRPTHQRTLSSQNIPPSPIRNNSADVSADGASQASNVAQTQHGTPRRGGSRLRLELANDSIIHSGFVESPTSATALDPSKASTPSRAMPPATAGDLSDSGDVGSPRTSKHGQTAEIDNHPLPMPRRRPRFVLPDLRKQLPPLAPLAAKKDNRPKPYTVEVPPSAPRYLVLNNKTDLLSRPGNTNAIPTANADFNPWMGDGPEDHFTQTFIQTGFFDKNPVAQAETTSAKSAIFPAIKHKSGLQALSTVFTGILASRRQNGQITSASTFKPPPRVTLTDTKREAWLKDLANSATSLRRLSRTIPHGIRGKGLLDQCLNKKVPTDRAVWLAKCVGANEIRAFKRKGVNGAVVMGGEAKWIRDWTMFVEQFVDAVVSSFGDADWKDKVNYAIRLSTHLYAEHLLDREHYMEWLVAGLENCPQAKLPMWLLLTQIYWKDLIKFRKYGRRLVTALLDQLTTIYNNPDHDIFASISSRLVILLKPLMASCASNFLSPTTWITHREALWSSLSLDDEMSQAAYRWINSRNEQLASSVQAPPAARHVLVQMLDGMLQTPMPADLPTRCWTTTQDQSNLARITLEWCSSFYRPGLAKVYIAYRLFSAWASLGLDVTVAILEFMNSDPLEEVEQKIALYHLVAELVHSGSFDPFGYIQWLIARGGLYDPSSVTRDGPASSRLLVELPVSALPPSLAIMRANMLGRASYNVYDEAIDQEKAIDYIKSTLGLHWGGGTQSVGMPIGKLCKRISLSSRSLKMEIGQFIRQAFVLSLDSAQMAGKEGFQLPSSTFIAVRSILEAAEDFQTLAQLLKSVTGSSDAEILASCADTLNLHLHVFGALGVANDLFDILVTRLENLKQMQGIAATRSLLVSVAMLAPQLAGQEALVNYLNETIRNDRSSAVDASSPVSDNMAARIQDEEGELLDEIEKRLANKTSMDRTTMNSFLNKIIPKVQACWGKTDERLRAYGLLLTRLRHFDTQHFDSFMTKWVLGIRNPQTRPPVSQIFPLMVSVGCLDFSIILATTSDAVSTTGRPNPAAKAAGLPHSTYIQEVLELFTAPPGSKELLTPEELYRFKILQHQAPKSHLKEMVALARNALAEYCACLSRRDSQGPALATPLKTTTGPPLAHPRTWERLLDLLRTLVLTDQVVVSKVLTMKTADPAVGQKMDDITTRLLFPNAQPGDQITLDQVLGLANEFTLPFCQLKLAQGLVSNELSPTNGPERQQNQMDAFARAMDNAIEARNITWTGMLPTLSPEITHHLLNRAQTRLFDLLPSKDRPAPPVTNFAMAESLLSVIDTISRGGPVGSRPSIQLASATVDRLADLWELLATPSEADIKVPILLSWLPLMLSFLTLQAHSHDITNKQSNEVRGRTLLVLAGILQEIDSLASLAVCDVRMPSNQTVSLSRRVFDLSLDLVDNLSEDVRQQCIRSLRDAVSDSRLRYIFSAAPAPLENLMLAHKDKPPTVSQQPGQQGQQQKSRATPFLGVGATNGNMWGTAVGPGGQGQERLSGFTFKRWEILNEPTPNVGENDTSLSLTLFESFKLR
Length1561
PositionKinase
OrganismValsa mali
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.06
Grand average of hydropathy-0.218
Instability index45.12
Isoelectric point8.75
Molecular weight171837.54
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08719
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     598.28|     182|     195|    1170|    1364|       1
---------------------------------------------------------------------------
   80-  167 (81.46/36.27)	......................................LELA.NDSIIHS...............GFVE...SPTSATALDPSKASTPSRAMPPA.TAGDLSDSGDVgsPRTSkhgqtAEIDNHPLPMPRRRPRFVLPDLRKQLPP...................................................................................
 1170- 1364 (283.12/186.71)	LTMKTADPAVGQKM.DDITTRLLFPNAqpGDQITLDQVLGLA.NEFTLPFCQ........LKLAQGLVSNeLSPTNGPERQQNQMDAFARAMDNAIEARNITWTGML..PTLS.....PEITHHLLNRAQTRLFDLLPSKDRPAPPVTNF........AMAESLLSVIDTISR.....GGPvGSRPSIQLASATVDRladlWELLATPS....EADIKvpilLSwLPLM
 1368- 1555 (233.70/126.84)	LTLQAHSHDITNKQsNEVRGRTLLVLA..GILQEIDSLASLAvCDVRMPSNQtvslsrrvFDLSLDLVDN.LS......EDVRQQ..CIRSLRDAVSDSRLRY...I..FSAA.....PAPLENL..........MLAHKDKPPTVSQQPgqqgqqqkSRATPFLGVGATNGNmwgtaVGP.GGQGQERLSGFTFKR....WEILNEPTpnvgENDTS....LS.LTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.15|      13|      15|      11|      23|       2
---------------------------------------------------------------------------
   11-   23 (25.76/14.77)	QRQPPSRSLSSSN
   27-   39 (24.39/13.53)	QRPTHQRTLSSQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.98|      59|     196|     496|     559|       3
---------------------------------------------------------------------------
  496-  559 (97.35/66.42)	SSRLVI.....LLKPLMASCASNFLSPTTWITHREALWSSLSLDDEMSQAAYRWINSrneqlASSVQAP
  695-  758 (96.64/56.25)	SSRLLVelpvsALPPSLAIMRANMLGRASYNVYDEAIDQEKAIDYIKSTLGLHWGGG.....TQSVGMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      14|      16|     254|     267|       5
---------------------------------------------------------------------------
  254-  267 (24.33/16.06)	AKSAIFPAI...KHKSG
  270-  286 (19.11/10.90)	ALSTVFTGIlasRRQNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.28|      13|      15|     587|     601|       6
---------------------------------------------------------------------------
  587-  599 (22.95/15.97)	WTTTQDQSNLARI
  603-  615 (25.34/10.84)	WCSSFYRPGLAKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.19|      17|     385|     385|     406|      10
---------------------------------------------------------------------------
  366-  382 (28.78/25.75)	FKRKGVNGAVVMGGEAK
  390-  406 (28.41/13.24)	FVEQFVDAVVSSFGDAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08719 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLAHKDKPPTVSQQPGQQGQQQKSRATPFLG
2) MSSRPPMGVPQRQPPSRSLSSSNTLSQRPTHQRTLSSQNIPPSPIRNNSADVSADGASQASNVAQTQHGTPRRGGSRLRLELANDSIIHSGFVESPTSATALDPSKASTPSRAMPPATAGDLSDSGDVGSPRTSKHGQTAEIDNHPLPMPRRRPRFVLPDLRKQLPPLAPLAAKKDNRPKPYTVEVPPSAP
3) YLVLNNKTDLLSRPGNTNAIPTANADFNPWMG
1472
1
193
1502
191
224










Molecular Recognition Features






MoRF SequenceStartStop




1) FKRWEIL
1530
1536