<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08714

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASASGSPFALRPLPLTLRDRKPASLVDFIARVNADKGGFRNVTEESLREELEAEAEADDVVDSKEVDMLDGESEVDGDAEQIGVEDFHEAVNEIRQNAEIAHQNAMLTVDFISLVLSKEMPSQAGTTVSPALRDLVGLGTLGADKLATSNIDDERLRDNKLVATGCKFADINRTVESVLTSASRLQEEISIETKYWAEVLAVSDKGWSVTRVPDEPETLGVRYGFSEAAPDFRNTSLAPMRRGDDGTVELDCGRMLGDPQRLLVTLEKNGRIVGQSALARPLPQDAPLQDRVLEARNTIFAQELWHEINREGRLLQNYGVRLEDSAVSYSINDDLRVVFALQPLERLVEEGASELLPEDSRAESLAAALHQLLTYAHRINNQKRTRPMPKNRIQSTTTPPYPLLRPVLTNLQHEISTQDVTRFISDLTTVLQSAGVTTALFRLREPPISLNLAETRGSYSEGLIEALFGPLEIQYEMNITPEARLLIHCKSVMINAIATTYHIYLLPPAQGELNPLQFAYPPVHVHGEGYSLPELKYYIQQAVARALTERASKTLATITPSSPQREDVLQAQWVKHVSGIALENDNDPKERLSFDVVCANPGTSGVHPELRVHGSWAAAGQPMAATRTWAWTVDDAAQGWQKESVDQVVCDVVARMVQPSVGTSGFGMI
Length670
PositionHead
OrganismValsa mali
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.06
Grand average of hydropathy-0.288
Instability index42.54
Isoelectric point4.89
Molecular weight73836.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08714
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     420.60|     106|     106|     180|     285|       1
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   33-  149 (99.55/59.36)	......VNADKGGfRNVTE....ESLREELEA..eaeaddvvdskevdmLDGESEVDgdaEQI.....GV.E...DFH.E.....AVNEIRQN.AEIAHQNAMLTV...DFislVLSKEMPSQAGT.TVSPALR.DLVGLGTL..GADKLAT
  153-  258 (148.28/92.07)	DDERL.....RDN.KLVATgckfADINRTVES................vLTSASRLQ...EEI.....SI.E..TKYWAE...VLAVSDKGWSVTRVPDEPETLGV...RY...GFSEAAPDFRNT.SLAPMRR.GDDGTVEL..DCGRMLG
  259-  365 (111.06/67.09)	DPQRLLVTLEKNG.RIVGQ....SALARPLPQ................dAP....LQ...DRVlearnTIfA..QELWHE......INREGRLLQNYGVRLEDSAV...SY...SIND...DLRVVfALQPLERlVEEGASELlpEDSRAES
  366-  462 (61.71/33.96)	LAAALHQLLTYAH.RINNQ....KR.TRPMPKnriqstttppypllrpvLTN...LQ...HEI.....ST.QdvTRFISDlttVLQSAGVTTALFRLREPPISLNLaetRG...SYSE..................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08714 with Med17 domain of Kingdom Fungi
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