<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08708

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGDPGPGYVSWQEQAATSYKEWDRFLQQALVQRLDFDKFAEYAPLLHSRYPLGPTPVADLLLRPAPWNKYTLDPRVPLYMQTLLDLKYIDTPAILRALYRYSTCHVLAGKNPEQKQEENAADGGGDKAAPPKQQKDGKEVTRWQSSFSSEEVIFYRLTKAVSQGAAIQNSRDSLEVATFMAKWMMLFTAASAAFPPDEDVMMGGAGGARRDKASQQSKDDMENSRAAFVMLLLGVCENHVVLEALSKPIAKGARKALSQSLANFVPSIMQNASQIAARLELFRTGVLAGFEPIDKKKEADNAEMDELLDETIGLQNVAIPDLHVTRSRAGLYIYLNAALVGRPLIDDASLYNHLHNRYQGDIQVTAIDLILGSFDVLANAIFRNEGQKSAHLLRSYLINKVPLVLASFAASATPMYPFNSELCITNALSRVDTNTFPTLSSLFENGLSSNPFTESVRSEFVAACCLHGLVPETSIDKLIGDYTYQTLPAGGRYVKDTLVQECLADPAHERMQKLIGELDNMDGNVGAVCQALTEMLGRLCTNHETMSLKTLCSQLARNPLNLDVLLLFDKTTTILNPLCQLLDNWTYEDDQGEYQPVYEEFGSILLLLVAFVHRYNLSASDLGIRSADSFVAKLLSKGLLSRPVEELNEQEKNQLNGWIHGLFDTDGGGLADELLSSCPPQDLYLLIPTLFHNIVLAFSTGYLTEESLKTGIEYLVEPFLLPCLVTAIIYLSNCLWTDRSEENKAIIKILQLILKPSQKMSQESSDMLNSVKNIVAKPLENGLRTYQRQNPKSQDVEPILQVLKDNIELSRRTGAAGDKELEQWTSSGSVGLTTAIKHTIQNLTMWSLHPGVMPTPYAHRQVLVGLRLLGAKRLLQAILEELKQLTETGNGSTAYDVAIGLVCAPDVMTTSDTPPSILDEAGQTPAPQQRRLSLREALKWKAEGWKKIQKHDPVMAETVVRLYQKVEAQMAPAAIAPLAHGADEAMNAMVGDVAAAAAASQLGMDDPMALDPSATAGLSLDLSGGAGDLSLGGGSGANSAGGLDLSGGDDMFSGLGPLEGWDGMDLT
Length1067
PositionTail
OrganismValsa mali
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.140
Instability index42.35
Isoelectric point4.99
Molecular weight116559.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08708
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.99|      18|      20|    1016|    1034|       1
---------------------------------------------------------------------------
 1016- 1034 (28.56/16.97)	AGLSLDLSGGaGDLSLGGG
 1039- 1056 (34.42/16.94)	SAGGLDLSGG.DDMFSGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.96|      14|      25|     973|     986|       2
---------------------------------------------------------------------------
  973-  986 (24.71/13.23)	AAIAPLAHGADEAM
  995- 1008 (25.25/13.67)	AAAAASQLGMDDPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.22|      14|      23|     253|     266|       4
---------------------------------------------------------------------------
  253-  266 (24.32/15.86)	ARKAL..SQSLANFVP
  277-  292 (19.90/11.57)	ARLELfrTGVLAGFEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.87|      58|     358|     468|     528|       5
---------------------------------------------------------------------------
  468-  528 (91.61/61.11)	GLVpeTSIDKLIGDYTYQTLPAG...GRYV.KDTLVQECLADpAHERMQKLIGELDNM..........DGNVGAV
  831-  902 (80.26/43.82)	GLT..TAIKHTIQNLTMWSLHPGvmpTPYAhRQVLVGLRLLG.AKRLLQAILEELKQLtetgngstayDVAIGLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.15|      35|     255|      40|     101|       6
---------------------------------------------------------------------------
   40-   81 (59.09/30.84)	AEYAPLLHSRYPLGPTPVA..DLLLRPAPWNKYtldprvpLYMQ
  302-  336 (55.47/17.64)	AEMDELLDETIGLQNVAIP..DLHVTRSRAGLY.......IYLN
  351-  371 (15.59/11.66)	..YNH.LHNRYQ.GDIQVTaiDLIL...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.43|      19|      26|     645|     663|       7
---------------------------------------------------------------------------
  645-  663 (34.47/22.10)	EELNEQEKNQLNGWIHGLF
  673-  691 (33.96/21.67)	ELLSSCPPQDLYLLIPTLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08708 with Med5 domain of Kingdom Fungi
Unable to open file!