<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08707

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGEYETNILLIDNVSSVAFKIYEPVVSNSATYTFSASDVEYTLRNRGNLVYADPLRRVIWCFSLTANDGSSIGQPGETILGANLDVCGYKLGLVEEGGLEPISLLKNRILAPNSLITPNSSSPSGSALDTAMRAAPTPGGIMNPAGFSLEGDAKTSFGPSVDSKGYGSIPAKDIHEYFIAAILASLSYRFCTKTGAIPLDSKTFILPSNTADSETSLPVSAPMVASLRVHLTTTGSLLIGMSLSIAQGLQTNSEGLSLSLPQNGATVLAAPFGVFGTCQLLADGDQTPVDGSTVESPDTQFRRFRPDMDGRSGQWRSTCYKLLEMRGISSAILSRSSWLNIQYLRRKPTESRSDGKRTPLISSQTHMMWPAVLCFRKRTRSPLTLNYTVDPSGISFRDGFDALDHARAWYISNGEREELLARRKHEREATGPKDTGEMDPRLLQQNSASSPLAMRRASNTGAAGGAMYPTPPDGVQNPAGVTFSIDGTTSSSESQVPSAALVDIDTTISAPGGLGDAFDDEWDGTESKRDQSLIQGDDWELNNDVFVDNDITDADFNFFDEQPGAMDVSMPDLSEMATVPKLEPPNQSTLSEPQRPPDTTALKVGNSPAPPVFAKPALKHARSSLGESRQRNNVKISPSNGIKRQPSPFDPAAVYKRLKASVGSGFQSNSNTITLPTRRGRVFDKLDFDSSLTVVNKKYEQSGRFDFHWDNEDETAPRQSKTLPTTDYLRRHGKSRKTLKELRSSLGAQITRFTGGVESHNIEIDPAKDGDSTSDADEVSLVSDQDDASDFSDEPSSPTKLGVRRRRLGDDNESLAPSLRDVEMMDESQAYSGVDLSKLFINDPSEMPIPRYFADSEPVSQRLAYGDDDFIMIAQILTEQAVSGSLKITTPDFTAAHLDVLSTQRDIVYGTRNSLQTLQTILPPCLQSASGCQLRQLLEVQDVPLLATPNRMQPRPPGGPEQRPSLVQIPPPHLDLRRHETRLSVLPSAAKFWESLGLGPSQGPKDVQSVCVFPNLDGMADNAGIFMDRLRSVYESLKLGNFERMSSSANTQNGLVPFAVDKTNNSPIASQGSRFGSPLIEDMAKLAVTIFNSTAVSTNFVIYFVYTPDNPNTIVESCAAFQRLFEIYKRALAERKKPAQNELVLQLVSLADITTSTSMVVLSPHNYARICLETYDRCTLFGGPMPSPAIVLEQPMTRGIDFHLRNPPSAHILHENSCMHIAYSQSVDERWITAAWSDNRGCKQMTASYCLGRKGKPLSRSFTEIAREIWMTTYDLTSIWKVHWRIIITKNGPMDQQEVSDWVSLAQTESSVTLVLLTVDTNPSLRLIPSMPKVPMTAQTAFYSTPVSTPQSSMVSPEQIGNPPTPKGAPTSAQNAMTPGADNNTAEAESDASLVDVTDTTWAAIASHRLNVSYSLVDPNPAMVSGYLIKRGGSRPEDPPAVMEVNVIHAEGNPRVHEILLREMLTYFRGLGTIARARSVTDEEGDVRPWHVAAAEKGLQALYQLM
Length1508
PositionKinase
OrganismValsa mali
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.367
Instability index50.44
Isoelectric point5.27
Molecular weight164549.06
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08707
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.87|      22|      97|    1304|    1327|       1
---------------------------------------------------------------------------
 1304- 1327 (32.41/26.39)	WVSLAQTESSVTLVLltVDTNPSL
 1404- 1425 (40.47/26.43)	WAAIASHRLNVSYSL..VDPNPAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     321.62|      90|      97|      79|     169|       2
---------------------------------------------------------------------------
   79-  169 (148.56/85.03)	ETILGANLDVCGYKLGLVEEGGLEPISlLKNRILAPNSL...ITPNSSSPSGSALDTAMRAA.PTPGGIMNPAGFSLEGDAKT.SFGPSVDSKGYG
  178-  266 (123.91/66.58)	EYFIAAILASLSYRF.CTKTGAI.PLD.SKTFIL.PSNT...ADSETSLPVSAPMVASLRVHlTTTGSLLIGMSLSIAQGLQTnSEGLSLSLPQNG
  267-  315 (49.16/21.46)	ATVLAAPFGVFG.TCQLLADGDQTPVD..GSTVESPDTQfrrFRPDMDGRSG............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.70|      19|      98|     467|     503|       5
---------------------------------------------------------------------------
  474-  492 (35.63/22.57)	PDGVQNPAGV..TFS..IDGTTS
  507-  529 (26.07/15.20)	DTTISAPGGLgdAFDdeWDGTES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.37|      33|      38|     607|     643|       7
---------------------------------------------------------------------------
  607-  639 (57.67/26.15)	GNSPAPPVFAKPAL.KHARSSLGESRQR.......NNVKIS
  645-  676 (40.71/24.66)	..KRQPSPFDPAAVyKRLKASVGSGFQS.......NSNTIT
  735-  767 (34.99/11.60)	GKS.......RKTL.KELRSSLGAQITRftggvesHNIEID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.49|      10|      38|     961|     970|       8
---------------------------------------------------------------------------
  961-  970 (19.96/11.04)	GPEQRPSLVQ
 1001- 1010 (20.53/11.61)	GPSQGPKDVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.03|      42|      46|     375|     416|      16
---------------------------------------------------------------------------
  337-  366 (34.36/15.24)	.......RSSwLNIQYL..RRKPTESRSDG......KRTPLISS.Q
  375-  416 (76.34/43.37)	LCFRKRTRSP.LTLNYT..VDPSGISFRDGFDALDHARAWYISN.G
  422-  463 (54.34/28.63)	LARRKHEREA.TGPKDTgeMDPRLLQQNSASSPLAMRRA...SNtG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.14|      32|     168|    1181|    1212|      22
---------------------------------------------------------------------------
 1181- 1212 (60.33/34.44)	TLFGGP...MPSPAIVLEQPMTRGIDFHLRN..PPSA
 1347- 1383 (49.81/26.97)	TPVSTPqssMVSPEQIGNPPTPKGAPTSAQNamTPGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08707 with Med13 domain of Kingdom Fungi
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