<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08703

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGAQNGLRTNHDRDLKLNGINGVSIVKREPSPSKLGKSSGAAVVNGGYDTPMDADPPNTQAQAATSAPDQDSKMKNLPPEIAHITQNFIPLPFILHRLAQKSHNDLQAKIEELAKIPIHGAVNGATGTAEDNSEENQNKKANLLHFIQDMHSKWVKALVISEWSRKASQVSRLIDLNVHISEQVGKYDLGLDFMGRIKRDLYGARLPDPDIKTALQVLSTGQAPWMPEFGYIDPPPLTVAEQLKWVGELNTLLSVRLNLEDHDKIPYQFRDYRIDSGRVTFKVKGEFEVDLTIADEDFEKQFWFINFRYNFSPAPQNLPEALMSFVEMKVNEALGTDGLRGCYEFLHEFVLTHKINELRRQAMVLSRGRWIEHIKIERLNRALSIQYWTTRFTATGPNAGPKSWIIVGINSAKTPPRNSPPGTRPTSYLALRWFRDGKEIKDVDVLADSEKISAEVLLKRIIAKHVEHILSSMYAKLLSKPRFEKRQASVSLSINSEEPSESTLVIQLTHSQTLTLHMNMTTGLFNMQPAARSLISRGEVFLNQRCKNPIEDGVIQIESIRWQSEFDEIIRRGKGSGWHMARRPVNSDEVKRLHPSREHCQTLWLKREGWGPAWYLVVCLSLAGDTWWLVEVMDDTPPTEAKGNPPKPRSKALNNQANVRNSAIIEQPAARIKTYNLLPITSANPELSVTFFTDLSALTTGMIAQITDITALRKNKIQYAAKRADNPYFSPRLKIPALYVRLASILPPQSGERKPKQPRGSWAEEFVQIVFRGVRGAAVPSSRRLEVSADVKIVVNDKSKFALIKGNVDHDVMYQPRTGQFRIQLRTEIGKSFIDPLTTRLKAIDRLVEFVAAMSSRANTVKCESVTLRKVVFTYGTPGTEQPAAGGQPNQPRWRVVLDLVRSEKVDITLEKGNPHIRVQDMLERLVNSPVGFEQLPYWLQVTLPLHRGLDSIEDSWAEVTANNQGDLQILPRALDWLSVHFELPGAPNKPPRKLCLSFKLKSRRGQLWWNMERHRRPDEAPKNEEDPFDAVLQPIFESRGDGWQGHGKSAVAHPNGKSIEGLLAKVSDAVKALATESSPPAPAGSQGAAIVVD
Length1096
PositionTail
OrganismValsa mali
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.434
Instability index44.82
Isoelectric point9.21
Molecular weight123082.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08703
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.73|      33|     176|      21|      64|       1
---------------------------------------------------------------------------
   21-   53 (57.81/25.16)	GINGVSIVKRE......PSPS.KLG...KSSGAA..VVNGGYDTP
  192-  236 (39.51/13.22)	GLDFMGRIKRDlygarlPDPDiKTAlqvLSTGQApwMPEFGYIDP
 1071- 1094 (26.41/ 7.29)	..DAVKALATE......SSPP.APA...GSQGAA..IV.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.21|      43|      82|     303|     351|       3
---------------------------------------------------------------------------
  303-  351 (70.78/67.78)	QFWFINFRynfSPAPQNLPEalmSFVEMKVNEA.....LGTDGLR.GCYEFLHEF
  388-  436 (71.42/49.84)	QYWTTRFT...ATGPNAGPK...SWIIVGINSAktpprNSPPGTRpTSYLALRWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.79|      64|     465|     516|     581|       4
---------------------------------------------------------------------------
  516-  581 (105.17/75.46)	LTLHMNMtTGLFNmQPAARSLIS......RGEVFLN.QRCKNPIE.DGVIQIESIRWQSEFDEIIR...RGKGSGWH
  584-  616 (35.15/16.25)	........................................RRPVNsDEVKRLHPSREHCQTLWLKR...EGWGPAW.
  980- 1047 (93.47/58.13)	LSVHFEL.PGAPN.KPPRKLCLSfklksrRGQLWWNmERHRRP...DEAPKNE....EDPFDAVLQpifESRGDGWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.39|      38|     106|     770|     809|       5
---------------------------------------------------------------------------
  770-  809 (59.82/41.47)	QIVFR.GVRG....AA..VPSSRRLEVSADvkIVVNDKSKFALIKGN
  872-  916 (53.57/31.32)	KVVFTyGTPGteqpAAggQPNQPRWRVVLD..LVRSEKVDITLEKGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.24|      13|     107|     639|     651|       6
---------------------------------------------------------------------------
  639-  651 (26.25/13.92)	PPTEAKGNPPKPR
  749-  761 (25.99/13.71)	PPQSGERKPKQPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08703 with Med14 domain of Kingdom Fungi
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