<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08699

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGEYETNILLIDNVSSVAFKIYEPVVSNSATYTFSASDVEYTLRSGGNLVYADPLRRVIWCFSLTANDGSSIGQPGEPILGANLDVCGYKLGLVEEGGLEPINLLKNRILAPNSLITPNSSSPSGPALDTAMRAAPTPGGIMNPAGFSLEGDAKTSFGPSVDSKGYGSIPAKDIHEYFIAAILASLSHRFCTKTGAIPLDSKTFILPSNTADSETSLPVSAPMVASLRVHLTTTGSLLIGMSLSIAQGLQTNSEGLSLSLPQNGATVLAAPFGVFGTCQLLADGDQTSVDGSTVESPDTQITRFRPDMDGRSGQWRSTCYKLLEMRGISSAILSRSSWLNIQYLRRKPSETRSDGKRTPVISSQTHIMWPAVLCFRKRTRSPLTLNYTVDPSGTSFRDGFDALDHARAWFISNGEREELLARRKKEREATGPKDTGDTDPRLLQQNSASSPLAMRRASNTGAASGAMYPTPPDGVQNPAGVTFSIDGTTSSSESQVPSAALVDIDTTISAPGGLDDAFDDEWDGTESKRDQSLIQGDDWELNNDVFVDNDITDADFNFFDEQPGVMDVSMPDLSEMATGVPKLEPPSQSTLSEPQRQPDTAALKASNSPAPPVFAKPALKHARSSLGESRQRNVKASPSNGIKRQPSPFDPAAVYKRLKASVGNGFQSNSNTVRSLARRGSVFDKLDFDSSLTIVNKKYEQSGRFDFHWDNEDETASRKSGSFPTTDYLRRHGKSRKTLKDLPSNLGAQIARFTGGVESHNIEVDPAKEGDSTSDADEVSLVSDQDDASDFSDEPSSPTKLSVRRRRLGDDNESLAPSIRDVEMIDEPQAYSGVDLSKLFINDPSEMPIPRYFADSEPVPQRLAYGDDDFIMIAQILTEQAVSGSLKITTPDFTAAHLDFSSKQRDIVYGTRNSLQTLQTILPPCLQSASGCQLRQLLEVQDVPLLATPNRMQPRPPGGPEQRPSLVQIPPPHLELRRHESRLSVLPSAAKFWESLGLGPSQGPKDVQSVCVFPNLDGMADNAGIFMDRLRSVYESLKLGHFERMSSSANTQNGLVPFEVDKTDNSPIASQGSRFGSPLIEDMAKLAVTIFNSTAVSRNFVIYFVYTPDNPNTIVESCAAFQRLFEIYKRALAERKKPAQNELVLQLVSLDDITTSTSMVVLSPYNYARMCLETYDRCTLFGGPMPSPAIVLEQPMTRGIDFHLRNPPSAHILHENSCMHIAYSQSVDERWITAAWSDNRGCKQMSASYCLGRKGKPLSRSFTEIAREIWMTTYDLTSIWKVHWRIIITKNGPMDQQEVSDWVSLAQTESSITLVLLTVDTNPSLQLIPSMPKVPMTAQSAFYSTPVSTPQSSMVSPEQIGNPPTPKGAPTSAQNATTPGADNNTAEADSDASLVDVTDTTWAAIASHRLNVSYSLVDPNPAMVSGYLIKRGGSRPEDPPAVMEVNVIHAEGNPRVHEILLREMLTYFRGLGTIARARSVTDEEGDVRPWHVAAAEKGVQALYQLM
Length1508
PositionKinase
OrganismValsa mali var. pyri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.376
Instability index51.91
Isoelectric point5.16
Molecular weight164252.32
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08699
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.66|      25|      46|    1023|    1067|       1
---------------------------------------------------------------------------
  995- 1019 (47.15/36.50)	WESLGLGPSQ...GPKDVQSVCVFPNLD
 1036- 1063 (38.51/24.09)	YESLKLGHFErmsSSANTQNGLVPFEVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.27|      19|      46|     154|     172|       2
---------------------------------------------------------------------------
  154-  172 (34.11/19.03)	DAKTSFGPSVDSKGYGSIP
  202-  220 (31.15/16.70)	DSKTFILPSNTADSETSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.49|      39|      47|     785|     827|       3
---------------------------------------------------------------------------
  785-  827 (56.78/43.35)	SDQDDASDFSDEPSsptKLSVrRRRLGDDN...ESLAPSIRDVEMI
  834-  875 (64.72/36.80)	SGVDLSKLFINDPS...EMPI.PRYFADSEpvpQRLAYGDDDFIMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.61|      34|      47|     356|     393|       4
---------------------------------------------------------------------------
  356-  393 (54.32/43.74)	DG......KRTPVISSQTHimwPAVLCFRKRTR...SPLTLNYTvDP
  400-  442 (48.29/26.62)	DGfdaldhARAWFISNGER...EELLARRKKEReatGPKDTGDT.DP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.09|      18|      47|     912|     929|       5
---------------------------------------------------------------------------
  912-  929 (33.69/23.08)	GTRNSLQ...........TLQTILPPCLQ
  949-  977 (26.40/16.15)	ATPNRMQprppggpeqrpSLVQIPPPHLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.84|      32|      46|    1101|    1132|       6
---------------------------------------------------------------------------
 1101- 1132 (57.73/38.72)	NFVIYFVYTPD...NPNTIVESCAAFQRL.FEIYKR
 1144- 1179 (44.10/27.74)	ELVLQLVSLDDittSTSMVVLSPYNYARMcLETYDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.98|      25|      46|      77|     101|       7
---------------------------------------------------------------------------
   77-  101 (43.47/25.77)	PGEPILGANLDVCGYKLGLVEEGGL
  125-  149 (45.52/27.36)	PSGPALDTAMRAAPTPGGIMNPAGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      28|      34|     620|     652|       8
---------------------------------------------------------------------------
  620-  652 (45.11/38.48)	AL.KHARSSLGESRQRNvkaspSNGIK...RQPSPFD
  655-  686 (39.50/22.57)	AVyKRLKASVGNGFQSN.....SNTVRslaRRGSVFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.18|      32|      34|     460|     492|       9
---------------------------------------------------------------------------
  460-  492 (53.76/32.23)	SNTGAASGAMYPTPPDgVQNPAGV..TFS..IDGTTS
  494-  529 (46.42/23.03)	SESQVPSAALVDIDTT.ISAPGGLddAFDdeWDGTES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.45|      18|     338|     251|     277|      10
---------------------------------------------------------------------------
  251-  268 (29.46/31.77)	LQTNSEGLSLSLPQNGAT
  287-  304 (30.00/10.74)	DQTSVDGSTVESPDTQIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.91|      49|     652|     719|     768|      11
---------------------------------------------------------------------------
  713-  762 (74.66/43.73)	N.EDETASRKSGsFPTTDYLRRHGKSRKTLKDLPSNLGAQIARFTGGVESH
 1380- 1416 (47.90/22.55)	.............TPGADNNTAEADSDASLVDVTDTTWAAIASHRLNV.SY
 1417- 1459 (64.35/33.21)	SlVDPNPAMVSG......YLIKRGGSRP..EDPPAVMEVNVIHAEGNPRVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.48|      17|      40|     182|     199|      13
---------------------------------------------------------------------------
  182-  199 (24.03/20.45)	AAILASLSHRFcTKTGAI
  223-  239 (29.45/18.55)	APMVASLRVHL.TTTGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.77|      19|     877|     327|     345|      14
---------------------------------------------------------------------------
  327-  345 (34.90/23.10)	MRGISSA.ILSRSSWLNIQY
 1206- 1225 (32.87/21.30)	LRNPPSAhILHENSCMHIAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08699 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FNFFDEQPGVMDVSMPDLSEMATGVPKLEPPSQSTLSEPQRQPDTAALKASNSPAPPVFAKPALKHARSSLGESRQRNVKASPSNGIKRQPSPFDPAAV
2) LARRKKEREATGPKDTGDTDPRLLQQNSASSPLAMRRASNTGAASGAMYPTPPDGVQNPAGVTFSIDGTTSSSESQVPSAALVDIDTTISAPGGLDDAFDDEWDGTESKRDQSLIQGDDWELNNDVF
3) LLATPNRMQPRPPGGPEQRPSLVQIPPPHL
4) TPVSTPQSSMVSPEQIGNPPTPKGAPTSAQNATTPGADNNTAEADSDAS
5) VESHNIEVDPAKEGDSTSDADEVSLVSDQDDASDFSDEPSSPTKLSVRRRRLGD
558
422
947
1347
759
656
548
976
1395
812










Molecular Recognition Features






MoRF SequenceStartStop




1) FAKPALKHAR
2) GYLIKR
3) PAAVYKRLKASV
616
1428
653
625
1433
664