<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08692

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMAGDLSDPGDVGSPRTSRRGQTAEIDNHPLPMPRRRPRFVVPDARKSMPPPAPPAAKKDNRPKPYTVEVPPAAPRYLVLNNRTDLLSRSGNTNALPTANADFNPWMGDGPEDHFTQTFIQTGFFDKNPVAQAETTSAKGAIFPAIKHKSGLQALSTVFTGILASRRQNGQITSASTFKPPPRVTLTDTKREAWLKDLANSATSLRRLSRTIPHGIRGKGLLEQCLNKKVPTDRAVWLAKCVGANEIRAFKRKGVNGAVVMGGEAKWIRDWTMFVEQFVDAVVSSFGDADWKNKVNYAIRLATHLYAEHLLDREHYMEWLVAGLENCPQSKLPMWLLLTQIYWKDLIKFRKYGRRLVTALLDQLTTIYNHPDHDIFASLSSRLVILLKSLMTSCATNFLSPATWITHRDAFWSALALDDEMSQAAYRWINSRNEQLVSSVQAPPAARHVLVQTLDGMLQTPMSADLPTRCWTTTKDQSNLARTTLEWCTSLYRPGLAKVYIAYRLLSTWASLGLDVTVAILEFMNSDPLEEVERKTALYHLVAELVRSGSFDPFRYIQWLIARGGLHDPSSVTRDGPASSRLLVELPVSALPPSLASMRANMLGRASYNVDDEAMDQERAIDYIKSTLGLHWGGGTQSVGMPIGKLSKRISLSSRSLKTEIGQFIRQAFVLSLDSAQMTGKEGFQLPSSTFIAVRSILESAEDFQTLAQLLKSVTGFFDAEILASCADTLNLHLHVFGALGVANDLFDILVTRLENLKQMQGIAATRSLLISVAMLAPQLPGQEALVNYLNETIRNDRSSAVDASSPVSDNMAARIQDEEGELLDEIEKRLANKTSMDRTTMNSFLNKIIPKVQACWGKTDERLRAYGLLLTRLRHFDTQHFDSFMTKWVLGIRNPQTRPPVSQIFPLMVSVGCLDFSIILATTSDAVSTTGRPNPAAKAAGLPHSTYIQEVLELLTAPPGSKELLTPEELYRFTILQHQAPKSHLKEMVALARNALAEYCACLSRRDSQGLALASPLETTGPPLANPRAWERLLGLLRTLVLTDQVAVSKVLSMKAADPAVGKKMDDITTRLLFPNAQPGDQITLDQVLGLANEFTLPFCQLKLAQGLGSSELSSINGPERQQNQLDVFAKAMDNAIEARNITWTGMLPTLSPEITQHLLNRAQTRLFDLLPSKDRPAPPAANFAMAESLLSVIDTISRGGPVGSHPSIQLASATVDRLADLWELLATPSDADNKVSILLSWLPLMLSFLTLQAHSHDITNKQSNEVRGRTLLVLAGILQEIDSLASLAVCDMRMPSNQTVCLSRRVFDLSLDLVDNLSEDIRQQCIRSLRDAVSDSRLRYIFSATPAPLENLMLAHKDKPPTVSQQPGQQGQQQRPRATPFLGVGATSGSMWGTAVGPGGQGQERLSAFTFKRWEILNEPTPNVGENDTSLSLTLFESFKLR
Length1443
PositionKinase
OrganismValsa mali var. pyri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index43.53
Isoelectric point8.58
Molecular weight159298.72
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08692
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     331.27|     124|     129|     322|     450|       1
---------------------------------------------------------------------------
  322-  389 (72.24/47.46)	..........................................................................GLENCPQS.KLP..........................................................................................................................................................................................................................................................................................mwLLLTQIYW...KDLIKFRKYGRRLVTALLDQLTTIYNHPDHDIFasLSSRLVILLKSL
  390-  511 (184.14/107.74)	MTSCATNFLS..PATWITHRDAFWSALA.LDDEMSQAAYR...WINSRN..EQlVSSV.QAPPAARHVLVqtldGMLQTPMSaDLP...............................................................................................................................................................................................................................................................................................TRC.WtttKD.......QSNLARTTLEWCTSLYRPGLAKVY..IAYRLLSTWASL
  515-  583 (49.44/21.53)	VTVAILEFMNsdPLEEVERKTALYHLVAeLVRSGSFDPFRyiqWLIARGglHD.PSSVtRDGPASSRLLV......................................................................................................................................................................................................................................................................................................................................................................
  868-  905 (25.45/ 6.74)	......................................................................................elpvsalppslasmranmlgrasynvddeamdqeraidyikstlglhwgggtqsvgmpigklskrislssrslkteigqfirqafvlsldsaqmtgkegfqlpsstfiavrsilesaedfqtlaqllksvtgffdaeilascadtlnlhlhvfgalgvandlfdilvtrlenlkqmqgiaatrsllisvamlapqlpgqealvnylnetirndrssavdasspvsdnmaariqdeegelldeiekrlanktsmdrttmnsflnkiipkvqacwgktderlraygLLLTRLRH...FDTQHFDSFMTKWVLGIRNPQT...RPPVSQIF..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.06|      21|     128|    1017|    1037|       2
---------------------------------------------------------------------------
 1017- 1037 (39.58/22.54)	LETTGPPLANPRAWERLLGLL
 1174- 1194 (32.49/17.07)	KDRPAPPAANFAMAESLLSVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.84|      41|     195|    1201|    1249|       4
---------------------------------------------------------------------------
 1201- 1249 (56.17/55.39)	GPvGSHPSIQLASATVDRladlWELL..ATPSDADNKVSilLSwLPLMLSF
 1398- 1440 (72.67/43.03)	GP.GGQGQERLSAFTFKR....WEILnePTPNVGENDTS..LS.LTLFESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.56|      18|      19|     636|     653|       6
---------------------------------------------------------------------------
  636-  653 (30.09/19.36)	QSVGMPIGKLSKR...ISLSS
  654-  674 (24.47/14.34)	RSLKTEIGQFIRQafvLSLDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.62|      19|     195|     709|     727|       8
---------------------------------------------------------------------------
  701-  719 (31.29/19.39)	EDFQTLAQLLKSVTGFFDA
  720-  738 (32.32/20.27)	EILASCADTLNLHLHVFGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.39|      16|      19|     207|     224|      14
---------------------------------------------------------------------------
  207-  224 (20.33/16.92)	LSRTIPHGiRGKgLLEQC
  225-  240 (29.06/14.19)	LNKKVPTD.RAV.WLAKC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08692 with Med12 domain of Kingdom Fungi
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