<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08689

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGDPGPGYVSWQEQAATSYKEWDSFLQQALVQRLDFDKFAEYAPLLHSRYPLGPAPVADLLLRPAPWNKYTLDPRVPLYMQTLLDLKYIDTPAILKALYRYSTCHVLAGKNPEQKQEENAADGGGDKAAHPKQQKDGKEVTRWQSSFSSEEVIFYRLTKAVSQGAAFQNSRESLEVATFMAKWMMLFTAASAAFPPDEDVMMGGAGGARRDKASQQSKDDMENSRAAFVMLLLGVCENHVVLEALNKPIAQGARKALSQSLANFVPSIMQNASQIAARLELFRTGVLAGFEPIDKKKEADNAEMDELLDETIGLQSVAIPDLHVTRSRAGLYIYLNAALVGRPLIDDASLYNHLHNRYQGDIQLTAIDLILGSFDVLANAIFRNEGQKSAHLLRSYLINKVPLVLASFAASATPMYPFNSELCITNALSRVDTNTFPTLSSLFENGLSSNPFTESVRSEFVAACCLHGLVPETSIDKLIGDYTYQTLPAGGRYVKDTLVQECLADPAHERMQRLIGELDNMDGNVGAVCQALTELCVLQMLGRLCTNHETMSLKTLCSQLARNPLNLDVLLLFDKTTTILNPLCQLLDNWTYEDDQGEYQPVYEEFGSILLLLVAFVHRYNLSASDLGIRSADSFVAKLLSKGLLSRPVEELNEQEKNQLNGWIHGLFDTDGGGLADELLSSCPPQDLYLLIPTLFHNIVLAFSTGYLTEESLKTGIEYLVEPFLLPCLVTAIIYLSNCLWTDRPEENKAIIKILQLILKPSQKMSQESSDMLNSVKNIVAKPLENGLRTYQRQNPKSQDVEPILQVLKDNIELSRRTGAAGDKELEQWTSSGNVGLTTAIKHTIQNLTMWSLHPGVMPTPYAHRQVLVGLRLLGAKRLLQAILEELKQLTETGNGSTAYDVAIGLVCAPDVMTTSDTPPSILDEAGQTPAPQQRRLSLREALKWKAEGWKKIQKHDPVMAETVVRLYQKVEAQMAPAAIAPLAHGADEAMNAMVDDVAAAAAASQLGMDDPMALDPSATAGLSLDLSGGAGDLSLGGGSGANSAGGLDLSGGDDMFSGLGPLEGWDGMDLT
Length1072
PositionTail
OrganismValsa mali var. pyri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.07
Grand average of hydropathy-0.132
Instability index42.87
Isoelectric point4.95
Molecular weight117214.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08689
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.99|      18|      20|    1021|    1039|       1
---------------------------------------------------------------------------
 1021- 1039 (28.56/16.61)	AGLSLDLSGGaGDLSLGGG
 1044- 1061 (34.42/16.59)	SAGGLDLSGG.DDMFSGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     503.87|     138|     143|     503|     644|       2
---------------------------------------------------------------------------
  421-  509 (101.24/62.19)	.........................ELCITNALSRVD.TNtFPTLS..SLFENgLSSNPFTESVRSEFVAACCLhgLVPetsIDKL.....IGD..YTYQ..............................TLPAGGR....YVKDTLVQECLADPAHE
  510-  651 (227.64/159.17)	RMQRLIGELDNM.DGNVGAVCQALTELCVLQMLGRLC.TN.HETMSLKTLCSQ.LARNPLNLDVLLLFDKTTTI..LNP...LCQL.....LDN..WTYEDDQGEYQPVYEefgsILLLLVAFVHRYNLSASDLGIRSADSFVAKLLSKGLLSRPVEE
  656-  788 (174.98/113.34)	EKNQLNGWIHGLfDTDGGGLADELLSSCPPQDLYLLIpTL.FHNIVLAFSTGY.LTEESLKTGIEYLVE...PF..LLP....CLVtaiiyLSNclWT..DRPEENKAIIK....ILQLILKPSQKMSQESSDM.LNSVKNIVAKPLENGL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.94|      18|      82|     123|     142|       3
---------------------------------------------------------------------------
  123-  142 (28.28/23.27)	GGG..DKAAhpKQQKDGKEVTR
  206-  225 (28.66/15.70)	GGArrDKAS..QQSKDDMENSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.00|      58|     591|     252|     360|       4
---------------------------------------------------------------------------
  265-  326 (86.76/74.51)	VPSIMQnasQIAARLEL.FRTGVlAGFEPIDKKKEADNAEMDELLDETIGLQSVAIPDLHVTR
  801-  854 (81.62/14.31)	VEPILQ...VLKDNIELsRRTGA.AGDKELEQWTSSGNVGLTTAIKHTI..QNLTMWSLH...
  885-  915 (40.62/36.71)	...........................EELKQLTETGN.G.STAYDVAIGL..VCAPDV.MTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.07|      36|     307|      25|      62|       5
---------------------------------------------------------------------------
   25-   62 (57.04/37.99)	FLQQALVQRLDFDKFAEYAPlLHSRYPlGPAPVA..DLLL
  334-  371 (60.03/32.26)	YLNAALVGRPLIDDASLYNH.LHNRYQ.GDIQLTaiDLIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.74|      27|      86|     150|     179|       6
---------------------------------------------------------------------------
  150-  179 (35.68/38.90)	EEVIFYRLTKAVSQGAAfQNSRESLevATF
  238-  264 (45.06/33.92)	NHVVLEALNKPIAQGAR.KALSQSL..ANF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.68|      19|      21|     971|     991|       8
---------------------------------------------------------------------------
  971-  991 (28.45/23.74)	VEAQMAPAAIAPLahGADEAM
  995- 1013 (33.24/20.35)	VDDVAAAAAASQL..GMDDPM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08689 with Med5 domain of Kingdom Fungi
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