Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKYVDARFERVEKALATLVESITKYTPQASQAADLSAADRELARGLRQLEVHQNNHQRLEALKAASSALDAQIRDTLRTLWTTRKDITSTATTVFPDGPHYDVNYEELLSYARRISKMTMPPPSIIASYGNVNGSGNGVNAGEDSAVSTGDAGQLGTQTTATSGTTALPAEWTQFLDPLTGHVFVPWAQDEKVRVGALASIQHLLEQGIDPRGYDPAEEEARRQREEEERREQEEKEAKEHEEVARKMREEQARIARERQQERERALEEAQRRGSTGGGPSPVAGPSEPQKRQFQFMGGDLDDDDDD |
Length | 308 |
Position | Middle |
Organism | Valsa mali var. pyri |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.909 |
Instability index | 47.54 |
Isoelectric point | 4.92 |
Molecular weight | 34261.15 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP08687 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 111.29| 34| 68| 190| 225| 1 --------------------------------------------------------------------------- 190- 225 (53.49/29.21) QDEKVRvgALASIQHLLEQGIDPRGYDPAEEEARRQ 261- 294 (57.80/26.84) QQERER..ALEEAQRRGSTGGGPSPVAGPSEPQKRQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ARIARER 2) ERALEEAQRRG 3) GPSPVAGPSEPQKRQFQFMGGDLDD | 254 265 280 | 260 275 304 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab