<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08682

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSFHPQTPQSPSHFSPSTTEPTVHSTMTSFTTNLPTPAHSINGTSLSLDSTHDMIMGEDSPQKRKRAQEDVGEQGHDQKRLHVDDGLPTLKDMHEDVGEKYLLLQKTWQPAQPVLSEDLFEMYDLTGIAGEVARVLPDGSKNALRKTYKGQIKKLGLMGHFDAVKKEPNDPNGLLGLLSVPDQEWHVHFVQGKDIEDGIRPDVKNVLTRATSMARGTIPKNKWDTSVLADFAGGPKGSSAKATATAPGTPLNPALSGVPRPKPLGIMAQEATRPRRANKKRSYGDSSFEGYEGYLDDETGAETGYSTGEGEGAKRRKKIAKSRVGTPRQAYGPGMVGV
Length338
PositionHead
OrganismValsa mali var. pyri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Valsaceae> Valsa.
Aromaticity0.06
Grand average of hydropathy-0.746
Instability index42.34
Isoelectric point7.89
Molecular weight36693.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08682
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.16|      14|      23|      52|      73|       1
---------------------------------------------------------------------------
   52-   73 (20.75/28.49)	HDmimgedspQKR..........KRAQEDVGE
   76-   99 (21.41/10.55)	HD........QKRlhvddglptlKDMHEDVGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.57|      19|      19|     139|     157|       2
---------------------------------------------------------------------------
  139-  157 (31.45/22.56)	GSKNALRKTYKGQIKKLGL
  159-  177 (34.12/25.12)	GHFDAVKKEPNDPNGLLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.46|      22|      24|       3|      26|       3
---------------------------------------------------------------------------
    3-   26 (34.32/26.78)	FHPQTPqSPSHfSPSTTEPTVHST
   30-   51 (39.14/21.07)	FTTNLP.TPAH.SINGTSLSLDST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08682 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DTSVLADFAGGPKGSSAKATATAPGTPLNPALSGVPRPKPLGIMAQEATRPRRANKKRSYGDSSFEGYEGYLDDETGAETGYSTGEGEGAKRRKKIAKSRVGTPRQAYGPGMVGV
2) MSFHPQTPQSPSHFSPSTTEPTVHSTMTSFTTNLPTPAHSINGTSLSLDSTHDMIMGEDSPQKRKRAQEDVGEQGHDQKRLHVDDGLPTLKD
224
1
338
92










Molecular Recognition Features






MoRF SequenceStartStop




1) TGEGEGAKRRKKIAKSRVGTPRQAYGP
2) YEGYLD
307
291
333
296