<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08679

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMALPPHPLPSRPPTTQPVPPRPPPPQGARPPAQPRPGVPLSLPSRPSFLPTPPVAATVPANSLSTHPPPSAASPRVPAPGTFPPASPAPSPHLRTALPGAATAAGGAAAPLPWPTQLEAGQATTTAQLIELGEGWVVRYRAWKAPARCLDPPLPVDAAADLLAWDPLAPACASSSATSAAAARKLASSTASSKGDDAAGPPSKKAKKGGPAARGAGNAFDELLAEELGSSTPALGGHPSPSLGTPLGSPSLLGPASAAPPPPTTRLPSALRAAMTAAASSSSSTAAADVGPSTASPAHGSASPDSDSSPSSRLRARLSALRAAAPSDPLALAEAHLAQRAAHARDDGRDRLALLSWVGSATVRVGGRAASAKGKGKAREGDEAAPKRERSEEREGDEGREGEGRALWVFGVVRGGETDAEGVKLDDLTFEGLEPFASGEFTHSSLFPALYSAAKSASSPTCASPLSLPAHAYPSALAISDALVSIPLIAQPPPPQTLVQAAYESFRSAISNILLDELVQQPVPDTRCVRLGASVVFLPLAAPTSSTSSSIRFAPLSPRPALELSLAPLALNRSSIHLQSRLAHLALAPLPPHVDAGARVRLAPLDARATFLRALRLPSSRRAQLDAEWTPHVAGACGSVAEPDRTQYVLCALDAPGGTAATSGDRVEVVWPRALVLLDGEREQAPSAARDGEQKAAASEPSPERPAAATSAAPVTSAVAPVAPPSRAFPGAPLRARLAGQLLLRGRTSGRRRGSEGSSAGDVGQAGAFRSPVKRRTGDVWRWMGDEGRRREEEKENAARREAEKDARDKEAAEAQAPESAAGKDDDKVVASAHLPAAAPINMRTPMSLGASSTEAPSPAELFSSSLHPIHAGAAHPPPPSSTVGGHDQSHDTLHGMDIDFGLGMYPSPAEPAGPHAPAPVSTSAPMSTLETAFPEFDWGDGTFGTSGMSGGGGGGAGGGGGGQGGGRGNDGNGGGYDDGIMLGLTDDDFSFFDAPTPARACDLGLSTMPSVSGMDAAFDLFSSSAPSDLPGMTSTVSTFAADPALTSTTSPQFPEGPSPALPFSFGAFDALTPNALELASTSPGAAALAAGPYSPVVLPTASATPASLALVPHTPHPVSYSPIIVGHASPQVSPGRARALSAFEPVAFDPAQAALDDKYDPRRGKFGLPSPDSDHEGRALVHPSAQSKDRRSWYSAVCDPRIALAERLRRQRLGPAKPPTQSSRLHCGASSSATAAAAPPPPPPHRAWVRRRLGAALGLVGGSIEGGSPSTSQHTADEADSEQSSSDSEKDDAMDVDRSPRAGRDSDDEPHDAEADRSLDAAFSSSLLAAVSFVKRGVEASSAAQYVLSSQDGAKVDPARDLTYHVVTEHLMHLPDLRDATLAFSRRPRRTSMAIASHALAIASTALAAVCSTLSPSPLFADHTALASLEQEDAPAFLLRTQQCVVETSCAAVDFWRPMGFEPLPGAKSVTAFVVYEDSGAEVHDTVKEWFRAIGSTYEGLRLGSHTPGTVPASNNFAGVQDGLVPLPAGLLSTSQQREELKLLYTALSDTSKTAQNTVVYLIAPLADSPLAQGSPLASIIHQVGKSRHGASAVNMLPCTIPMASLARSGPSTSTSSTAGRLARLAFSVYDQLQIPVERLRFPMPETFPSARPPPLAPLGPAIRLYTAPAVNVAPAASSRAVQFSLSWPPMALEVEHRHRLLHVCYTSRRLAEDSEQECLVVATVDEKGESWKVAPRLIKAPVGPLADVQRVRLVWSFVKSLVDAVDVEWRIVLCKLGEPTGLEAKTWDSLLKEYLAVVRRPLHVTFACAELDPALAVLPRHAFPAQSSAASFTSIEDGQASVAGSVGSVGSGKTTLFDATPTTLTYTPTEPVSLSTLAFTPAASSYFLHVPRISSHAHSTVDLGSPIDPSSTSAYAVHFFLSHASRTSSYKATLGALVGDVRRSFVELAALGQVRWGTSGRLAWHLEATGLALLLAEQLS
Length1981
PositionKinase
OrganismRhodotorula graminis (strain WP1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.05
Grand average of hydropathy-0.185
Instability index58.16
Isoelectric point6.17
Molecular weight204868.42
Publications
PubMed=26441909

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08679
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.56|      16|      19|     939|     954|       4
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  939-  954 (31.12/12.63)	GDGTFGTSGMSGGGGG
  960-  975 (28.44/10.81)	GGGQGGGRGNDGNGGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     294.34|      46|      46|     516|     561|       6
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  257-  297 (51.92/13.35)	AAPPPPT..T.RLPSALrAAMTAA..ASSSS.STAAAD....VGPSTASP....A....
  489-  518 (37.53/ 7.31)	AQPPPPQT.LV..................QA.AYESFR....SA.ISNIL....LDELV
  519-  564 (71.82/21.71)	QQPVPDTR.CVRLGASV.VFLPLA..APTSS.TSSSIR....FAPLSPRP....ALELS
  565-  614 (42.00/ 9.18)	LAPLALNRsSIHLQSRL.AHLALAplPPHVD.AGARVR....LAPLDARAtflrAL...
  992- 1034 (46.93/11.26)	FDAPTPAR.ACDLGLS.......T..MPSVSgMDAAFDlfssSAPSD.LP.....GMTS
 1068- 1102 (44.14/10.08)	FDALTPN........AL..ELAST..SPGAA.ALAA.......GPYSPVV....LPTAS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.02|      15|      16|     802|     817|       7
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  802-  817 (22.26/17.06)	AEKDaRDKEAAEAQAP
  821-  835 (26.76/16.00)	AGKD.DDKVVASAHLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     293.84|      47|      47|     655|     701|       8
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   85-  144 (44.48/11.53)	ASP...APSPhlRtalPGAATAagGAAA.PLPWP.....TQ..L.......EAG..QATTTAQlieLGEgwvvryraWKA
  145-  179 (46.30/12.36)	.........P........ARCL..DPPL.PVDAA.....ADLLAWD....P..L...APACAS...SSA........TSA
  180-  216 (36.24/ 7.77)	AAArklASS........TASSK..GD...DAAGP.....PS....K....KAKK..GGP.AAR...GAG...........
  654-  695 (64.31/20.57)	........AP..G...GTAATS..GDRV.EVVWP.....RALVLLD....GERE..QAPSAAR...DGE........QKA
  696-  740 (42.22/10.50)	AAS...EPSP.eR...PAAATS..AAPVtSAVAPvappsRA...FP....G......APLRAR...LAG........Q..
 1128- 1179 (60.29/18.74)	ASP...QVSP......GRARAL..SAFE.PVAFD.....PAQAALDdkydPRRGkfGLPSPDS...DHE........GRA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.03|      30|      33|    1601|    1630|       9
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 1565- 1594 (33.41/12.15)	.PLADspLAQGSPLASIIHQVGK.SRH..GASAV
 1601- 1630 (49.91/22.58)	IPMAS..LARSGPSTSTSSTAGRLARL..AFSVY
 1635- 1666 (46.70/20.55)	IPVER..LRFPMPETFPSARPPPLAPLgpAIRLY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.70|      19|      33|     363|     381|      12
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  363-  381 (32.20/15.72)	RVGGRAASAKGK.....GKAREGD
  393-  416 (25.49/10.77)	REGDEGREGEGRalwvfGVVRGGE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.16|      15|      16|      29|      43|      13
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   29-   43 (29.96/11.31)	RPPAQPRPGVPLSLP
   45-   59 (27.20/ 9.49)	RPSFLPTPPVAATVP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.24|      15|      16|     307|     322|      14
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  307-  322 (20.64/12.45)	SSPSSRLRARLsALRA
  326-  340 (25.60/11.62)	SDPLALAEAHL.AQRA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.54|      14|      16|    1733|    1748|      15
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 1733- 1748 (18.14/18.16)	KVapRLIKAPVGPLAD
 1751- 1764 (23.40/14.40)	RV..RLVWSFVKSLVD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.43|      10|      16|    1297|    1306|      16
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 1297- 1306 (19.02/10.19)	DRSPRAGRDS
 1316- 1325 (17.41/ 8.52)	DRSLDAAFSS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.28|      29|     146|     892|     924|      17
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  895-  924 (52.17/23.92)	GMDIDFGLGMYPSPAEPAGPhAPA.PVSTSA
 1038- 1067 (50.11/18.14)	TFAADPALTSTTSPQFPEGP.SPAlPFSFGA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.06|      27|      37|    1210|    1237|      18
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 1210- 1237 (43.52/22.04)	RQRLGPAKPPTQSSrLHCGASSSATAAA
 1250- 1276 (46.54/20.08)	RRRLGAALGLVGGS.IEGGSPSTSQHTA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.98|      14|    1216|     632|     645|      19
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  632-  645 (26.39/13.43)	VAGACGSVAEPDRT
 1843- 1856 (24.59/11.98)	VAGSVGSVGSGKTT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.83|      32|      34|    1454|    1485|      22
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 1454- 1485 (58.58/34.65)	DFWRPMG..FEPLPGAKSVTAFVVYEDSGAEVHD
 1489- 1522 (53.25/30.71)	EWFRAIGstYEGLRLGSHTPGTVPASNNFAGVQD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.85|      23|     765|    1105|    1127|      23
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 1105- 1127 (44.64/22.69)	PASLALVPHTPHPVSY...SPIIVGH
 1872- 1897 (36.21/16.87)	PVSLSTLAFTPAASSYflhVPRISSH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.77|      28|     151|    1371|    1410|      24
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 1382- 1409 (47.09/34.51)	LAFSRRPRRTSMAIA..SHALAI.ASTALAA
 1796- 1826 (42.68/10.60)	LAVVRRPLHVTFACAelDPALAVlPRHAFPA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08679 with Med13 domain of Kingdom Fungi
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