<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08675

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASTTQLSLEPLQPFAGDGHDSDLFARPARLREVRLDDGREVFTRDDPKKSLQERLARVWAERGDYSELSEERILNPAKEHELADKEDKDPRPTVDDIRALQETMINNLALARGELTTALDLLSVLSAPRDPPDVDVASLPLPQQTLSFVPTAPPPRPSTDPQQNPLAPIPLASSLDALSRSARAFFSASEELVPLSDEELAALASSNSAAASRPRPRQRARAPDPWPTILRLHHGGARTLAPLGAGKGASLAAGKGESRTARSVGVFFGAQEAGAAWRRASVAEVGELLDEGAEKRKGRRMVVEVGVEGAGKMERAVWDEEDDKAQDAMDEEEKGDDVDRVERVLKARGRAVFAEELFSQLTSEARSESALRAELQLGSRTEGDTIALSGSGWTVRVTMATTPDSSTPSHATAATLSSLLRLLFLQEYTARRTSTPNSAPRPLLATVAAYLGHAQRVDALRGVLERLRAKACEGEGEVEAAVAFDGEDEGQGAGRQAADVLHVLNGASVLGGRATLRLGKSTVFTVLYSSPLPPSPHAAAQAPPPSLPPSLQPTLTLRVPGRPAPLQLPSLRHLETFLGEQVDRACRVESARREKEREGAGEDKDKEGL
Length610
PositionHead
OrganismRhodotorula graminis (strain WP1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.04
Grand average of hydropathy-0.472
Instability index47.63
Isoelectric point5.31
Molecular weight65546.61
Publications
PubMed=26441909

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08675
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     427.64|     121|     140|     289|     427|       1
---------------------------------------------------------------------------
  112-  172 (82.88/31.75)	ARGELTTALDLLSVLSAPRDPPDVDVASL..............PLPQQTLSFVPTAPPPR.PSTDPQ...QNPLAPIPL..................................................................................................................................................................
  289-  329 (33.11/ 6.61)	................................................................................assldalsrsaraffsaseelvplsdeelaalassnsaaasrprprqrarapdpwptilrlhhggartlaplgagkgaslaagkgesrtarsvgvffgaqeagaawrrasvaevgeLLDEGAEKRKGRRMVVE....VGVEGAGKMERAVWDEEDDKAQDA
  348-  494 (172.59/104.71)	ARGRAVFAEELFSQLTSEARSESALRAELQLGSRTEGDTIALSGSGWTVRVTMATTPDSSTPSHATAATLSSLLRLLFLQ.............................................................................................eytarrtstpnsaprpllatvaaYLGH.AQRVDALRGVLErlraKACEGEGEVEAAVAFDGEDEGQGA
  495-  603 (139.05/64.78)	..GRQ..AADVLHVLNGA..SVLGGRATLRLGKSTVFTVLYSSPLPPSPHAAAQAPPPSLPPSLQPTLTLRVPGRPAPLQ.......................................................................................................lpslrhletflgeQVDRACRVESARR...E....KEREGAGE................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.64|      18|     121|      56|      93|       2
---------------------------------------------------------------------------
    9-   28 (29.59/25.01)	LEPLQPFA.GDGHDSDlfARP
   75-   93 (29.04/ 8.07)	LNPAKEHElADKEDKD..PRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.08|      27|      46|     184|     214|       3
---------------------------------------------------------------------------
  184-  210 (43.23/18.40)	RA..........FFSASEELVPLSDEELAALASSNSA
  222-  258 (36.85/18.08)	RApdpwptilrlHHGGARTLAPLGAGKGASLAAGKGE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08675 with Med17 domain of Kingdom Fungi
Unable to open file!