<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08669

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTPGEEYIMRARLEVNRSGGAAGACSPGSCGGASPAPAVSAPSSAGAPPPSPHLTALTTHQTGGAVPTTLHTPAPTPDPHAPPTPAPPSAPPHKTYTQLLRRPALPPAEQRLDPLEDEHSLHMLYDYTTVHAWLEHPVKRFKTDTREWSEELALGARGGDLYAGHAHTPPPAPHPARPQRPARAHHTPLAPLAADVKQERLDEDSKEYKNLFTSDGLCPTLKDLDQIFDNSDDAASGDETALAGGAGEAGRCDEARCGGRCVRAEELSKMFPTPPSMEAHAQPSPGFSLPEEATPQPHRHLLPSSPPPDPIEDWSYVFKPPTVCKYVGSSKYAPLVALPSQLLPSVALPPHAVYRPRWQQDAKRDPDTDTDTDTKRNEVSVAGHGAERGGREEWRCAWRTGAEQVGNIRGADVGTYLSHGEAAAGELDAGRCDCGFSAIVNRRLAHRAGLFYEDEMEITGLAEDPGGRGGVRGTRGAAGLAEVAGVLAEQCAAPPGGPASALSRAAADAKPSHDHLRLNLLEYSDGGAAAASALREAAAGGPVAGASAGAGAGAGAHCAVHRWPFIGARAPRSSRDVVRLMRRLRPLLQDAIQKRCCGARMWDGVTGPLTWRQFHRLAGRGNEDLCEPQPVPPLLVGHDRDWISLSPYALRHWERLSLEPYSYARDVAYVALAPDGEALTDPLRAFFRELSTAYEACRLGRHQPIARIARDGIVRTAAGERSDTDDWAGELPPGRLGEYIRAYADTLRELTSQLSSMNIERVLFEAEKGNNMRPPAAPEQPGTPGEPGEGGEVPAGGSASAPVWEEDEAGPPALVLYLVEPPAAHAHRAHALHALLRLAAQAHHHLHHHNPYIKIISLEGVYECWAGRGAWGAGRGGGAELRTLAFSVFSGARRLLQHQPNGKSLTGFGTAANANLFLNNKDEKNRAAYRLFTPAWVLAPPRALREVAETWGTACGEQCSVLFVAYCLSHDQRWLLAAATDARGELLDTAAINIHVPARSRRRRSAPARRLGLTKLMDFTLGVMSQAAQPWRLVVGRVGRIGHGELKGWSYLLSRKNLVRASSVLREICGSCAALYPGGAPCVLSACLVSTEPDPCLRLMADRFTPDERFSQASIQSHLHTPRDVTATHILVFPTSAKTQSNQMPFEQPMANGEDNDIFMDVDMGDEDIGEDNMADLIINDMFTNMGPEKMRSIDKADEQVGTILQQPLALGYLVSTAPLGAMPAWWWAGCAHLRDSCPAFLKNALHLHSGSAQTSDDFTSLMQRRDNNSHPLDSQTTTDVLRYVLEGYNALSWLTLDGSTHDRLSCLPLHVQALMQLYHTAAALG
Length1326
PositionMiddle
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.394
Instability index47.99
Isoelectric point6.13
Molecular weight142845.06
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08669
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     705.47|     113|     113|      71|     183|       1
---------------------------------------------------------------------------
   45-  164 (185.64/58.21)	.AGAPPPS...PHltALT.............THQ.........................TG..GavpttlHTP......APT..PDP.......HAPPT.........PA.......P.........PSA..PPHKTYT..QLLRRPALPPAEQRLDPLEDE......HSLHMLYD.YTTVHAWLE...HPVKRFKTDTREWSEELALGA......RGGDL..YAG
  165-  250 (119.62/35.12)	HAHTPPPA...PH..PAR.............PQR.........................PA..R....ahHTP.....lAPL..AAD.......VKQER.........LD.......E.........DSK..EYKNLFT..SDGLCPTLKDLDQIFDNSDDA......AS................................GDETALA........GGAG..EAG
  280-  418 (105.82/30.30)	HAQ.PSPGfslPE..EAT.............PQ..........................PH..R.....hLLP.....sSPP..PDPiedwsyvFKPPTvckyvgsskYA.......PlvalpsqllPSValPPHAVY.......RPRWQQDAKR.DPDTDT.............D.TDTKRNEVSvagHGAER..GGREEWRCAWRTGAeqvgniRGADVgtYLS
  419-  560 (110.80/32.04)	HGEAAAGE...LD..AGRcdcgfsaivnrrlAHRaglfyedemeitglaedpggrggvrGT..R......GAA....glAEV..AGV.......LAEQC.........AA.......P.........PGG..P.....A..SALSRAA...ADAK..PSHDH......LRLNLL.E.YSDGGAAAA...SALREAAAGGPVAGASAGAGA......GAGAH..CAV
  561-  637 (99.01/27.92)	H.RWPFIG...AR..APR.............SSR.........................D...............................................................................vvRLMRR..LRPLLQ..DAIQKR......CCGARMWDgVTGPLTW........RQFHRLAGRGNEDLCEPQ......PVPPL..LVG
  774-  879 (84.57/22.87)	....PPAA...PE.qPGT.............PGE.........................PGegG......EVPaggsasAPVweEDE.......AGPP...........AlvlylveP.........PAA..HAHRAHA.lHALLRLA....AQAHHHLHHHnpyikiISLEGVYEcWAGRGAW......................GAGR......GGGA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     368.74|     117|     300|     642|     765|       2
---------------------------------------------------------------------------
  642-  765 (187.35/124.90)	WISLSPYALRH....WERLSLEPYSYARdVAYvALAPDGE....ALTDPLRAFFRELSTAYEA...CRLGRHQPIARIARDGIVRTAAGERSD.TDDWagELPPGRLGeyiRAYADTLRELTSQLSSMNIER...VLFE
  936- 1067 (181.39/101.94)	WVLAPPRALREvaetWGTACGEQCSVLF.VAY.CLSHDQRwllaAATDARGELLDTAAINIHVparSRRRRSAPARRLGLTKLMDFTLGVMSQaAQPW..RLVVGRVG...RIGHGELKGWSYLLSRKNLVRassVLRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.82|      17|    1041|      25|      41|       3
---------------------------------------------------------------------------
   25-   41 (35.92/16.98)	CSPGSCGGASP..APAV.SA
  252-  264 (27.17/10.98)	CDEARCGG......RCV.RA
 1069- 1086 (23.73/ 8.61)	C..GSCAALYPggAPCVlSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08669 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DTREWSEELALGARGGDLYAGHAHTPPPAPHPARPQRPARAHHTPLAPLAADVKQERLDEDSKEYK
2) EAEKGNNMRPPAAPEQPGTPGEPGEGGEVPAGGSASAPVWE
3) MTPGEEYIMRARLEVNRSGGAAGACSPGSCGGASPAPAVSAPSSAGAPPPSPHLTALTTHQTGGAVPTTLHTPAPTPDPHAPPTPAPPSAPPHKTYTQLLRRPALPPAEQRLDPLEDEHSL
4) RAEELSKMFPTPPSMEAHAQPSPGFSLPEEATPQPHRHLLPSSPPPDPIEDW
5) VYRPRWQQDAKRDPDTDTDTDTKRNEVSVAGHGA
144
765
1
263
353
209
805
121
314
386










Molecular Recognition Features






MoRF SequenceStartStop




NANANA