<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08662

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMTESKPLAMANTNGLMDKSKELQKEILMEKLRSKTSQYKNLNETSKAVRMALLDKRWAVDSADRQILQKCLDSLQHCIKVSSLQSLIERLECLSRQLGLKFVVGTSGVNLFISSDMFYLEILVESLGSVKDVKIHHEGKIEQQSCEEMVASITRGDFADFTAQLEGLIAVYQLNAEKKVKCKAFSALQSLEEDLCTLRQLQSFIKDPWAQVHKSPIGFLQKRRGGHAMRLTYFVSPYELLDKEKGLQPLTTELLTLGKPAASSGLASLVAPSHTPVGYSATILLEGSTANKLQLCPIISSGQRSGKGNGPVYAPLVPQNSAMLPACFTLRLSQPMPLCTGLAKLIHATTEHLPEQTQCYFICESRGLEGCVVRSVPFTHPSHVPPLLACLRQQALFNTLIASCVRLQNKQVVEMEGVVMLEVSAVSWQHISVSLEHPADESVATLELSLSEPAAPRAAVCTLHAPPSEHVDEYVTRVLQKSHSIPVTLRSLVKIWKMEAKQMNGNYSALDSNFSCDLGGLDPGQQHHLSMICQDPNSSESKPQTDERKSKKRKSDDLWSSSQKKGKQGITEAADSESDSDNSYVNEDDNTMNSNSTNEEGPESSVSQNEFASDLELSAMDATDALSTHDNRSSDMDNSNDGEPEEMIRNSFHKSEHKRQKLKNKESDSRSSRSSASLLLDLTDGKSYMPSSVSITPIGSSSSSSASAASGTNLSSMLCLDRRPGIEIIPISSATPATLPSSITITPITSSQLKSLDSRSDKKSSKSSEERSKEKKKKRRRDDSMGPPEKVPPKQDPLTKPVSVSIKPTDGSPMRPSSPNSILRKFSPSPTHGRSVSITKSPSPSSVKSLGKPTGTSSHHSSPRHSPVQNSPKHLTGYSSPKNHSISSPKHSSSGSGKPSMSTLKSATTGSPSGKSGTTGYDLSKKISKDSYGSSSMTSRDKEKKHSSLSFSTSDRSSPKLKNQTKLKQLEITPVSCDSPVAEPLISPPNIEVNKSNTPSSQARNRKGSLSAVIDKLKSAHHSADTDIGSGKSGSSSSTNKFSDPKNSAAGSGMKVSESKNQEYMVKPSSDGMKITINKTRSKESSGSKLNYSSSKQSSPQLTPPSQGSPKTHTGLKPGVISGPASKKTQAMQSSKSGLSTSSTPPKNNTSPSESSGSSSLPKVPYSKSSSGSSTGINLSKSASKTSSGSPKNSNSDLSKIIRDREREKVRTKLMSNSEKSIFSSKSERHSSPSSSRDDVDGDRYKASKEANFLVEGLIKPLDTSKFQIPKLKNQNTPDKNSPVSQYDSRSLVNDFARTLDQNKFPFSHFDNTNARNAESLQKSGYTLNVPKPLLNVGAMSPKTVSSSKLDQADRADFSKNLEGLGKGESPQRSKDDSKEGFPGAFPMMPLDFKTDMAKGFPAPKGSSEDRKGADSCMKPPASGSVARSGATTPQEAAEMLLDFSSSSGSKVSGMVAVRPVYPASPALALQLAKSPAPSPLVAPSPHSNSPCITDDELMDEALVGPGK
Length1507
PositionMiddle
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.04
Grand average of hydropathy-0.652
Instability index63.02
Isoelectric point9.23
Molecular weight162036.26
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08662
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     341.67|      42|      42|     790|     831|       1
---------------------------------------------------------------------------
  728-  768 (39.35/10.21)	IPiSSA.TPAT....LPSSI.TI.....TPITSSQLK..SLDSRSDKKSS...KSSE
  790-  831 (69.07/23.90)	VP.PKQ.DPLT....KPVSV.SI.....KPTDGSPMRPSSPNSILRKFSP...SPTH
  835-  873 (39.49/10.28)	VS.ITK.SP......SPSSVkSL....gKPT.GTSSHHSSP....RH.SPvqnSPKH
  874-  912 (42.72/11.76)	LT.GYS.SPKN....HSISS.PK.....HSSSGSG.KPS..MSTLKSATT...GSPS
  915-  951 (37.88/ 9.53)	SG.TTG.YDLS....KKIS.........KDSYGSSSMTSRDKE..KKHSS...LSFS
 1102- 1147 (40.80/10.88)	TP.PSQgSPKThtglKPGVI.S......GPASKKTQAMQSSKSGLSTSST...PPKN
 1163- 1206 (34.91/ 8.17)	VP.YSK.SSSG....SSTGI.NLsksasKTSSGS...PKNSNSDLSKIIR...DRER
 1222- 1262 (37.45/ 9.34)	FS.SKS.ERHS....SP.SS.SR.....DDVDGDRYKASKEANFLVEGLI...KPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.30|      32|      39|    1349|    1383|       2
---------------------------------------------------------------------------
 1349- 1383 (48.53/35.42)	LDQadRADFSKNLEGlGKGESPQRSKDDS..KEGFPG
 1390- 1423 (52.76/28.50)	LDF..KTDMAKGFPA.PKGSSEDRKGADScmKPPASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     349.95|      85|     308|     952|    1036|       3
---------------------------------------------------------------------------
  528-  574 (35.09/ 9.00)	..............................................LSMI..CQDP...NSSESK..PQTDERKSKKrksddLWSS.SQKKGKQGI...TEAAD
  575-  642 (64.89/23.49)	...SESDSDnSYVNEDD.NTMNsNSTNEEGP.ESSVSQNEFASdleLSAMdaTDAL.............................S.THDNRSSDMDNSNDGE.
  643-  706 (58.60/20.43)	........P.EEMIRNSFHKSE.HKRQKLKN.KESDSRSSRSS...ASLL..LD.LtdgKSYMPSsvSITPIGSSSS.....SSAS..................
  969- 1052 (127.42/53.90)	LEITPVSCD.SPVAEPLISPPN.IEVNKSNT.PSSQARNRKGS...LSAV..IDKL...KSAHHS..ADTDIGSGKS.....GSSSsTNKFSDP..KNSAAGSG
 1053- 1101 (63.96/23.04)	MKVSESKNQ.EYMVKPSSDGMK.ITINKTRSkESS.......................................GSK.....LNYS.SSKQSSPQL........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.44|      56|      60|     187|     245|       4
---------------------------------------------------------------------------
  187-  245 (91.93/63.55)	LQSLEEDLCTLRQ..LQSFIKDPWAQVHkSPIGF....LQKrrGGHA..MRLTYFVSPYELLDKEKG
  246-  309 (80.51/46.18)	LQPLTTELLTLGKpaASSGLASLVAPSH.TPVGYsatiLLE..GSTAnkLQLCPIISSGQRSGKGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.76|      21|      56|     374|     394|       5
---------------------------------------------------------------------------
  383-  439 (18.23/ 7.11)	VPPLLACLRQQAlfntliascvrlqnkqvvemegvvmlevsavswqhiSVSLE.H..PA.D
  442-  469 (17.52/ 6.50)	VATLELSLSEPA.................................aprAAVCTlHapPSeH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.49|      17|      56|    1425|    1442|       6
---------------------------------------------------------------------------
 1425- 1441 (27.87/10.78)	VARSG..ATTPQEAAEMLL
 1449- 1467 (23.62/ 7.32)	SKVSGmvAVRPVYPASPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.24|      26|      30|     313|     338|       8
---------------------------------------------------------------------------
  313-  338 (48.68/27.96)	APLVPQNSAMLP...ACFTLRLSQPMPLC
  342-  370 (43.56/24.30)	AKLIHATTEHLPeqtQCYFICESRGLEGC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08662 with Med1 domain of Kingdom Metazoa
Unable to open file!