<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08659

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGIMYEKRPLKRPRLGPPDVYPQEPRQKEDELTSTNVKHGFATTPQSSDEFGTARNFNYSASKIGQFFSSILSKKEELNTLPDCGRKRQQVNPKDNFWPATARTKAQIEAWFKDLAGSKPLSILAKKAPNFNKKEEIFMTLTEYQVAMPRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTTTLIKFLKDQIPKLAEHYQSAVPTNPLEKTPPSQSGQGTPSHNSSGNQSGGTTPNSTIPNSMHSPGMGESTDWRQALKLWNYCCRLARYMLDEGLLDRHDFLTWIIELLDKRGPEDGLLRLFLPLALQHMSEFVCCEGLSRRLATTCAKKAAAICSVLSDTTLRALNQPAVFTKTADASDKVNGIPMSPAPENTNGDVKPNINQIKRSATPAESQGTPNPNHSLGTPNPNHSIGTPVPIGTPNPTQSMDVQVKEERGSPPRDVKTTLNTVITAALNPVQMGFSEILNCAYHRDIIIQLATVLQVYEAEQEIAARSKKAESKWCTDKWQTSSQARVLAVLEALDRHCFDRVDPNNNLDTLYKEVFANCTPPSSKDSSTDTKDPEWACSYAVVRVLCEWAVCGARWGEHRAMAAAALLDRRQQLLHLHHDHHATGSDDKESISSGTGLYNGPPIFQNLLLRFLDNDAPVLDESPNAPPGNRQQFANLVHLFGELIRRDVFSHDAYMCTLISRGDLISPTEPTSTGGTSGHTVAPPVNSTGTNHNMDDDIFAGIDLKPKMEENVRMELDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKDPGEPVHSLNSPMMGPSGMSIANMQSIGMGPMSVPGIRSSSACGGVGGVGGVQSGGASSAPVSRHYHYTMHFPLPPAEPEHTPHDANQRHILLYGVGRQRDDAKHAVKKMTKVVEGGKIKKHSRSEFNFEAVTQKFQAMSMYEQGAVSWAVGGAVCEALAAYAAGATTYLPQPEHVAFALDLMEIALNVHGLIETCIQVLKELSEVEGALITRGAPSSGLAAPRAYTSALALCTVGALRRYHSCLLLCVEQTSAVFEQLCRLVKCVVNPGDCGSAERCVLAQLHDLYKAAAHLCHAPYADTFANAYPKIKQALYSPVQPIPAKYKYDPEFLSEFFMNPRKGKIEIAWARQVAESPANRYNFVCSAMLAVCREVDNDRVNELGVVCAEMTAWCSALAPEWLGALVALCGAQHYPAPKPQAPQCPSPQPNRPCSPPPPPPLYPDLLCHRDLHDAAAHDALAVFTCILVARHCFSLEDFVRHAALPSLVKACGGGGANNPPNAPSPETSARLTCHLLLRLFKTVDTPQPGLYSVSTSPGPGGGAAGVRLSCDRHLLAAAHKNIGVGPVLATLKAILMVSDLSARDGGKPSGKKSSELSHILGTSDTVPTDAQLDLMSMVESEMSGGHRTPRGSGGVGSTLLDSSQSLSSLARRMLAEICCEEWVLQKCLQNPDELYLPDMLLDSMLTPRQAQRLLHMICYPDTASHTHPDLDQKTMITRLLENLEQWSLRMSWLDLQLMFNQFPPGSPELSAWLDTVARAVINVFQQPAPPPPDKDRTGTDRGVVSTSKWSESVWLVAPLVAKLPAAVQGRVLKQAGQILESGWGAGCSGGCAGGGGGGSHRDCKSHQSPSYKGSAGGGGGGKRGVSGMSGSGCACGGAAAVRLANEPLLSLVLTCLRHQDDQKESLLSSIHAQLAHYLSRAREQERAACGDAHDEVPADALLLRFSLAGGMFDAIRRSYQLTSDWAVLLTQLLAHQVIACEPLGCLVDQKGNKISGFDSDKKQGLRLTDKQRVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHRLLKYHTHSLVQPQSYYLESIPLPPEDLETNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKVATPTNVGSNVGVGGGVGLAAPAQQPQFIQSQQQWFPPPGATYYNPPAAGVSPRSVTQASTTQCKQALSNMLRQRVPFNQMTQMQVIACEPLGCLVDQKGNKISGFDSDKKQGLRLTDKQRVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHRLLKYHTHSLVQPQSYYLESIPLPPEDLETNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKVATPTNVGGNVGVGGGVGLAAPAQQPQFIQSQQQWFPPPGAAYYNPPAAGVSPRSVTQASTTQCKQALSNMLRQRVPFNQMTQMQQNTGYPGAPHPRAPFPRQGMRQMQPNQMSQMQPNQMNPMSAMGNMGPMGQMAGVQMGPGQMGAGQMGSGQMGQSQMGGGQMGSGQMPGMAGQMFGSQYGGMQQGYGGYGQQMMQGGQQQMMNQAMGQSVNQMSQQVNQMGQGVNSIGQNVGQMSQGVGQGGQMPQGMGQMGQSMGQMSQAISQMGQMGQGGGMGQMNSQASSMGPQGGNAMGGFLGQQSFQHQQNMMSGRASQEAFLAQQRQNARPQYMQAPNVTMGGMSGPAPPYPRNMQPQQSAQYGQQLTPQLRMRQQVLAMQQQQQQGPLVQHLQRQQYQPPY
Length2514
PositionKinase
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.454
Instability index51.81
Isoelectric point8.38
Molecular weight272335.33
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP08659
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     256.26|      36|      37|    1892|    1927|       1
---------------------------------------------------------------------------
 1892- 1927 (69.86/26.40)	ATPTN.VGSNVG.VGG.GVGLAA..PAQQPQFIQSQ.QQWFP
 1931- 1967 (32.15/ 7.97)	ATYYN..PPAAG.VSPrSVTQAS..TTQCKQALSNMlRQRVP
 2114- 2149 (71.20/27.06)	ATPTN.VGGNVG.VGG.GVGLAA..PAQQPQFIQSQ.QQWFP
 2269- 2300 (43.25/13.40)	GQSQM.GGGQMG.SGQ.MPGMAG..QMFGSQYGGMQ.Q....
 2337- 2374 (39.80/11.71)	GQGVNsIGQNVGqMSQ.GVGQGGqmPQGMGQMGQSM.GQM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     688.57|     144|     220|    1748|    1891|       2
---------------------------------------------------------------------------
  840-  892 (30.71/11.82)	..............................................................................................PVSrhYhYTMHFPLPPAEPEhtPHDANQRHILL....YGVGRQRD.DAKHAVKKMTKV
 1166- 1218 (47.82/23.87)	EMTAwCSALAPEWLGALVALCGAQ..HYPAPKPQAPQCPSPQpnRPCS......PPPPPPL...........................................................................................
 1748- 1891 (303.99/204.38)	QLLA.HQVIACEPLGCLVDQKGNKISGFDSDKKQGLRLTDKQ..RVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHRLLKYHTHSLVQPQS..Y.YLESIPLPPEDLE..TNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKV
 1970- 2113 (306.05/205.84)	QMTQ.MQVIACEPLGCLVDQKGNKISGFDSDKKQGLRLTDKQ..RVSSWELVEGGRNPAPLSWAWFAATKIERKPLTYENAHRLLKYHTHSLVQPQS..Y.YLESIPLPPEDLE..TNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.10|      13|      19|    2225|    2243|       4
---------------------------------------------------------------------------
 2225- 2237 (29.91/ 6.21)	MSQMQPNQMNP..MS
 2245- 2259 (20.19/ 9.31)	MGQMAGVQMGPgqMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.79|      17|      19|     383|     401|       5
---------------------------------------------------------------------------
  365-  379 (22.44/ 6.15)	VNGIPMSPAPENTNG..
  385-  401 (29.36/21.34)	INQIKRSATPAESQGTP
  404-  419 (25.99/13.20)	.NHSLGTPNPNHSIGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.04|      19|      20|    1607|    1625|       6
---------------------------------------------------------------------------
 1315- 1330 (24.18/ 8.13)	G.PGGGAAGVRLSCDRH..
 1607- 1625 (41.65/19.86)	GCAGGGGGGSHRDCKSHQS
 1630- 1646 (34.22/14.87)	GSAGGGGGG.KRGV.SGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.00|      13|      18|    2406|    2422|       7
---------------------------------------------------------------------------
 2406- 2420 (19.77/ 7.40)	NAMGGFLgqQSFQHQ
 2496- 2508 (19.23/ 6.62)	QQQGPLV..QHLQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.53|      15|      17|     778|     792|       8
---------------------------------------------------------------------------
  778-  792 (28.92/15.88)	PKDPG.EPVHSLN.SPM
  795-  811 (19.61/ 7.89)	PSGMSiANMQSIGmGPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     145.59|      21|      21|    2177|    2197|       9
---------------------------------------------------------------------------
 2179- 2200 (30.11/11.43)	ALSNMLRQRVPF.........NQ..MTQMQ.qNT
 2201- 2221 (28.09/10.10)	GYPGAPHPRAPF.........PRqgMRQMQ....
 2317- 2335 (30.55/11.72)	MMNQAMGQSV...........NQ..MSQQV..NQ
 2423- 2451 (23.66/ 7.18)	MMSGRASQEA.FlaqqrqnarPQ..YMQAP..NV
 2452- 2474 (33.18/13.45)	TMGGMSGPAPPY.........PR..NMQPQqsAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.91|      15|      20|    1509|    1524|      10
---------------------------------------------------------------------------
 1509- 1524 (28.44/18.68)	WLD......LQlMFNQFPPGSP
 1529- 1549 (26.47/12.32)	WLDtvaravIN.VFQQPAPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.48|      19|      19|    1124|    1142|      11
---------------------------------------------------------------------------
 1124- 1142 (35.29/23.77)	IAWARQVAESPANRYNFVC
 1146- 1164 (33.19/21.88)	LAVCREVDNDRVNELGVVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.61|      13|      19|    1663|    1675|      12
---------------------------------------------------------------------------
 1663- 1675 (23.48/15.68)	EPLLSLVLTCLRH
 1681- 1693 (22.13/14.30)	ESLLSSIHAQLAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.77|      14|      17|     138|     151|      13
---------------------------------------------------------------------------
  138-  151 (26.18/16.75)	FMTL.TEYQVAMPRA
  154-  168 (18.59/ 9.72)	FIKLsSAYTVAVSEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.68|      14|      16|     522|     535|      14
---------------------------------------------------------------------------
  500-  512 (18.79/ 9.08)	.KAESKWCTDKWQT
  522-  535 (25.00/14.63)	LEALDRHCFDRVDP
  539-  552 (22.89/12.74)	LDTLYKEVFANCTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.29|      13|      20|     916|     928|      16
---------------------------------------------------------------------------
  916-  928 (24.94/15.01)	QAMSMYEQGAVSW
  936-  948 (21.35/11.69)	EALAAYAAGATTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.24|      15|      22|    1027|    1043|      19
---------------------------------------------------------------------------
 1029- 1043 (26.48/20.85)	EQTSA...VFEQLCRLVK
 1050- 1067 (21.76/ 7.47)	DCGSAercVLAQLHDLYK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08659 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DASDKVNGIPMSPAPENTNGDVKPNINQIKRSATPAESQGTPNPNHSLGTPNPNHSIGTPVPIGTPNPTQSMDVQVKEERGSPPRDVKTTLNTV
2) EDLETNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKVATPTNVGGNVGVGGGVGLAAPAQQPQFIQSQQQWFPPPGAAYYNPPAAGVSPRSVTQASTTQCKQALSNMLRQRVPFNQMTQMQQNTGYPGAPHPRAPFPRQGMRQMQPNQMSQMQPNQMNPMSAMGNMGPMGQMAGVQMGPGQMGAGQMGSGQMGQSQMGGGQMGSGQMPGMAGQM
3) EDLETNDIKQDNGSLDSSPTGAGKGRKMPCKNNKAKKPKVATPTNVGS
4) GQQQMMNQAMGQSVNQMSQQVNQMGQGVNSIGQNVGQMSQGVGQGGQMPQGMGQMGQSMGQMSQAISQMGQMGQGGGMGQMNSQASSMGPQGGNAMGGFLGQQSFQHQQNMMSGRASQEAFLAQQRQNARPQYMQAPNVTMGGMSGPAPPYPRNMQPQQSAQYGQQLTPQLRMRQQVLAMQQQQQQGPLVQHLQRQQYQPPY
5) LISPTEPTSTGGTSGHTVAPPVNSTGTNHNMDDDIFAGIDLKPKMEENVRMELDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKDPGEPVHSLNSPMMGPSGMSIANMQSIGMGPMSVPGIRSSSACGGVGGVGGVQSGGASSA
6) YEKRPLKRPRLGPPDVYPQEPRQKEDELTSTNVKHGFATTPQS
7) YQSAVPTNPLEKTPPSQSGQGTPSHNSSGNQSGGTTPNSTIPNSMHSPGM
360
2074
1852
2313
696
5
201
453
2290
1899
2514
839
47
250










Molecular Recognition Features






MoRF SequenceStartStop




1) MGIMYEKRPLKRPRLGPPDVY
1
21