<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08657

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVPVAIEGCTQGAEGGGARGGSISLALLIDFIVQRTYDELTVLAELLPRKTDIERKIEIYKFSARTRQLFVRLLALVKWASSATKVDRSAHIMAFLDKQALLFVETADVLARVARETLVHARLPTFHMAAAVEVLTLGTYSRLPAVIRERLVPPPSLTPAERRSTLRALAHVVRQRLTTASLPTDVRNLKVENGRATFSVGQEFSVSLTVMGDAPNLPWRLLDIAILIQDYETGEGKPLVHTSQLAWLRGVAQARLAAAGLSGALTALRYFCRSLSLELLYTQTLRLCRDRLAKHLQVDKYIPGQKLQVSYWRELGCELGYRVIIGAEAESLSMWHVPALAGGERVAAALTPHAPSMERLLAHTVHVRSRQRLNDLKVLFNDLGVECTVSGWPCVLACSVVWPCLRAEQLLVSVGAHGGRLRARVPAYPATPRMPELAAALAAANLPLVKSLLTQLRYWLVARRCEKTVQHLPASVCEHLPFLHGPDHPLNKLSTDRLYVTLHRHTDYLLIVEMKEVAAGSTATTSNCSNSGSASSVALAFHLAGARRCTPDECEDESGATSSANASPASRAFLKLHSLVELDTFTLTHGPFTPLDTPGMQAGKRKLASANTRALRVRQPAYFLPELAHVVAAADERVPFVNLAQELAARGVTHGGVMPEWSGSALGMRIVALPRPEGASERAAEALRMRLLAATIRLTTKNQARLGLHHVRTQMPTPTFTLLAHSWRKIRIIYAGAYSLEVGIRGGNMVTIRDGSYSKFDRTTVVDEFAPALGLKTFLSRYVDDNISARLLAEEENPPSPMSPMPPGGLRFPAPLTPPQPHTPHSAPVTPHPASPAQHQMGGGSFNLTSPPGGGTGGSGAGVSASPASPLAPSPLAPAASPHPPPTSPYTPWLGSPSLPRPSPGHHPSPRHHIDHKGPQVSSSTTSGSRGGGVRGGAGSSAAPLTVAKLELLCTPSEPPPGAPPGPPLAPLQRFLACVYLKRTLPRFIQQEEFLSLVCMEATSVTFRCESAGLSARVALHPQHMQSLHLQLSVLPEHKEILSPDDLQVMEKFFETRVAIPPYRSSALHGWARAFGAPPVALPSLAALMRADLAPAALAASAPAPPLWQLQWALRIPPAAPQIVPAGHPAVLNAKNKILFFICLTRGDTQLVLPLVYDSQNNSTQLADKRDAQPHLLAVNLHLKRFSEFNQTHSECTLWPAVRDLLTNFTLPQEAPPATAQPPP
Length1224
PositionTail
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.06
Grand average of hydropathy-0.045
Instability index49.27
Isoelectric point9.45
Molecular weight132157.98
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP08657
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.30|      15|      18|     801|     818|       1
---------------------------------------------------------------------------
  801-  815 (31.78/ 8.13)	PMSPMPPGGLRFPAP
  873-  884 (27.60/10.87)	P.SPLAPAA..SPHP
  956-  968 (30.92/ 7.58)	PSEP.PPGAPPGP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.45|      37|      67|     818|     859|       2
---------------------------------------------------------------------------
  818-  859 (68.10/51.01)	PP.QPHTP.HSAPVTPHPASPAQHQMGGGsfnLTSPpgGGTGGS
  885-  910 (34.36/13.60)	PPtSPYTPwLGSPSLPRP.SPGHHP.........SP........
  911-  941 (49.99/24.71)	...RHHID.HKGP..QVSSSTTSGSRGGG...VR....GGAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     305.48|      77|      78|     278|     355|       3
---------------------------------------------------------------------------
  278-  355 (133.36/80.73)	ELLYTQTLRL.CRDRLAKHLQVDKYIPGQK.L..QVSYW...RElGCELGYRVIIGA.EAESLSMWHVPALA....GGE...RVAA.ALTPHAP
  358-  435 (107.54/60.48)	ERLLAHTVHVrSRQRL.NDLKVLFNDLGVE.C..TVSGW......PCVLACSVVWPClRAEQL.LVSVGA.H....GGRlraRVPAyPATPRMP
  437-  505 (64.59/33.08)	...............LAAALAAAN.LPLVKsLltQLRYWlvaRR..CEKTVQHLPAS.VCEHLPFLHGPDHPlnklSTD...RLYV.TLHRH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.80|      24|      79|     159|     190|       4
---------------------------------------------------------------------------
  106-  125 (26.96/ 7.05)	TADVLARVARETLVHAR.LPT....
  127-  149 (25.82/ 6.19)	..HMAAAVEVLTLGTYSrLPAVIRE
  165-  188 (40.03/32.99)	TLRALAHVVRQRLTTAS.LPTDVRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.41|      34|      67|     573|     608|       7
---------------------------------------------------------------------------
  573-  608 (54.79/31.57)	FLKLHSlvELDTFTL.THGP..FTPLDTPGMQAGKRKLA
  611-  639 (23.09/ 6.72)	..........NTRALrVRQPayFLPELAHVVAAADERVP
  640-  672 (55.53/27.20)	FVNLAQ..ELAARGV.THGG..VMP.EWSGSALGMRIVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.64|      38|     839|     236|     273|       8
---------------------------------------------------------------------------
  236-  273 (63.41/39.70)	GKPLVHTSQLAWL.RG.VAQARLAAAGLSGALTALRYFCR
 1038- 1073 (55.11/33.22)	HKEILSPDDLQVM.EK.FFETRVAIPPYRS..SALHGWAR
 1076- 1115 (50.13/29.32)	GAPPVALPSLAALmRAdLAPAALAASAPAPPLWQLQWALR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08657 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARLLAEEENPPSPMSPMPPGGLRFPAPLTPPQPHTPHSAPVTPHPASPAQHQMGGGSFNLTSPPGGGTGGSGAGVSASPASPLAPSPLAPAASPHPPPTSPYTPWLGSPSLPRPSPGHHPSPRHHIDHKGPQVSSSTTSGSRGGGVRGGAGSSA
789
942










Molecular Recognition Features






MoRF SequenceStartStop




NANANA