<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08655

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDNLKQFNTMGSEDNWRTSNFRQNVVSKIEEVIQRSGMQVARNSSEMENHVYMKAKTREEYMNMVAKLILHVREMSQPKQNQAGGSMQGNNQNQPGPNPQVQTQQGQAPQGPNSQPGLAPDPINALQNLASQGTRNQMMNMGQGQMQQQGVMGPNPGMAGLQAQIGQQGPIVSQGGPQSQAATNLLQTLTQRPQLNMQQMQNKLSMGMVPNQNQMGNNMVSMGGMGNPMGSQLQNQLAGPGMQGQMMPNMSMSNNMQVPMSGSSTMVGQMQCNQVVGGMGGQMAPNAMQGQMSRQMVGGMTNNQMVNMNMLHMQGRVGAKGEVVGGMMGNGYAPAGAPSHNQFLRQSPSPSASSPNMGGPSPVSMGGSVLGGALASPMSSLGAMGACNGVGSPSPSAPAHLPHHPTQQQRGVGVGMGMVASPSSSLNTPAGGGGGVASPGGEEAVYREKVRQLSKYIEPLRRMVQRMVNEGENVEKLTKMKNLLDILSNPNKRMPLETLIKCEVVLEKLDFKRSETVCVILPPAGTGKHEQIFNPLLEVINNCLLSPVSNHTLKRTFGHTLDALNGPEIKNLPPPYKMPKVEEPTMEIPDVLQGEIARLDSRFKVSLETMQLSGGSGAIALVAQLDDVRLPCVPAVHVAVPRDYPAHAPSRLRPRAPRPDAHRAFLAQVDRNMDARCARLPKSCSVGQLLDAWEMSVRQACAPSPVAYTPVPALGL
Length716
PositionTail
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.03
Grand average of hydropathy-0.449
Instability index55.15
Isoelectric point9.34
Molecular weight76541.15
Publications
PubMed=26354079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP08655
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     338.48|      54|      55|     105|     158|       2
---------------------------------------------------------------------------
  105-  158 (110.30/32.56)	QG...Q.APQGP.N..SQPGL.APDP...INA.LQN.LASQ...G..TRNQMM.NMGQ...............GQMQQQGVMGPNPGM
  159-  208 (53.66/12.48)	AGlqaQiGQQGPiV..SQGG...PQSqaaTNL.LQT.LTQ........RPQ.L.NM.Q................QMQNKLSM....GM
  212-  279 (64.08/16.17)	QN...Q.M..GN.NmvSMGGM.G.NP...MGSqLQNqLAGP...G..MQGQMMpNMSMsnnmqvpmsgsstmvGQMQCNQVVG...GM
  281-  323 (45.64/ 9.63)	................GQ..M.AP......NA.MQG.QMSRqmvGgmTNNQMV.NM.................NMLHMQGRVGAKGEV
  345-  395 (64.81/16.43)	R....Q.SPSPS.A..SSPNMgGPSP...VSM.GGS.VLGG...A..LASPMS.SLG................AMGACNGVGSPSP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.74|      21|      25|     562|     586|       3
---------------------------------------------------------------------------
  562-  586 (30.42/28.86)	DALNGpEIKNLPPPYKmpkVEEPTM
  590-  610 (36.32/19.51)	DVLQG.EIARLDSRFK...VSLETM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.15|      18|      23|     637|     658|       4
---------------------------------------------------------------------------
  637-  658 (28.85/27.03)	HvavpRDYPAHAPSRLR...PRAPR
  662-  682 (26.30/14.31)	H....RAFLAQVDRNMDarcARLPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.38|      16|      24|     448|     467|       5
---------------------------------------------------------------------------
  448-  463 (28.28/25.96)	EKVRQLSK.......YIEPLRRM
  472-  494 (21.10/ 6.82)	ENVEKLTKmknlldiLSNPNKRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.94|      19|      24|     518|     537|       6
---------------------------------------------------------------------------
  518-  537 (30.95/22.01)	CvILPPAGTGKHEQIFNPLL
  543-  561 (33.98/19.75)	C.LLSPVSNHTLKRTFGHTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.61|       9|      16|     413|     422|       7
---------------------------------------------------------------------------
  413-  422 (15.86/ 9.92)	GvGMGMVASP
  431-  439 (19.75/ 8.29)	G.GGGGVASP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08655 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAMGACNGVGSPSPSAPAHLPHHPTQQQRGVGVGMGMVASPSSSLNTPAGGGGGVASPGGEEA
2) MDNLKQFNTMGSEDNWRTSNFRQNVVSKIEEVIQRSGMQVARNSSEMENHVYMKAKT
3) NMVAKLILHVREMSQPKQNQAGGSMQGNNQNQPGPNPQVQTQQGQAPQGPNSQPGLAPDPINALQNLASQGTRNQMMNMGQGQMQQQGVMGPNPGMAGLQAQIGQQGPIVSQGGPQSQAATNLLQTLTQRPQLNMQQMQNKLSMGMVPNQNQMGNNMVSMGGMGNPMGSQLQNQLAGPGMQGQMMPNMSMSNNMQVPMSGSSTMV
4) PAGAPSHNQFLRQSPSPSASSPNMGGPSPVSMGGSVLGG
382
1
63
334
444
57
267
372










Molecular Recognition Features






MoRF SequenceStartStop




NANANA