<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08650

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMADLQITNIVSDILRVEPVEEAFSSYLVYKPEQENEKLTMYQKKLCTMMTSLSADLQESAIRQYLTHTAIQTNQYKMKQLLTILENLVNTNILQARMVCDCILGNDNLIYQNADYWIQCFNLIRRIIGGVDYKGVREIMKGCREKAHSLPMKLNSSTIPQMKALYNVIEYIFDRNASLLPAYFIVTEIQKDYPDNNHYPHWELASLFTSFIESFRPCAQMVSIIGHSSMLPVVEFSGYADHLINPWRLDPTTLKFSLKGNLPYDDELLKPQIALLRHVIQQPYSRDMMCSMLGLQKQHKQRCIALEDQLVELMISPMEKSEQENEDDEMSSTHWCWLHLSSQVIYLILIGFASFSNIVMGLHNKLTGHNLKKGRDHLMWVLLQFISGSIQRHPLSDFLPIIKLHELLYPEKEPLPVPDWTRAHSTHQMAVVCIWMHLLKKAETDNKTMSMPQNLKVQYEFLQHLMSSNNTPALMGGDYRIPLLCNAYSTKQECYTRPMGIIIETLFGIQKALPNGNPGTPLPTMPLSMCILDSLTLHCKMSVIHSIVTHVAKLAQNKTNLPGSSMMAPALVETYSRLLVYTEIESLGIKGFINQLLPTVFKSHAWGILHNLLDMFSYRIHHIQTHYRVTLLSHLHSLAACPQANQTQLQLCFESTALRLITSLGSSGVQLQMSRVVSEPKSLVSADSEELNRVLVLTLARGIHMTGTGSDSAAVKELLTTIMTNTPHNWSQHTLQCFPPVLVEFFSQNPAPKENKQLLKKFVEEEYRKWSSMANDNDIVSHFSVPGAPLFLCLLWKIIFETNRINPIAFKILERIGARAFSAHVRKFCDYLMYEVTNPAGGPHINKCVDAINDIVWKYNIVTIDRLVLCLVLRPNLDGNESQVCLYIIQLLLLKGSELRNRAQAHDCMNGLKSQLYEKHLAFHRKYPEKFAPEEASGTYGGTIPVYLSNVCLRIIPVLDVVVHRHLEIPQVSKNLEQLLEHIGYLYKFHDRPITFLYNTLHYYELKLRDKPLLKRKLVNAVLGSLKDVRPTGWATTEAFQSYLARPEVDATSWTPDLNYYLSLVNRMVDTMTGQSHFPNTDWRFNEYPNPSAHALYVTCVELMSLPFPPNVVGNSLLEIITSGFVVIPTTKIQLWVNAVGLIMAALPDPYWNVIHDKILELITSNEMIEWPYSESPFQIFNLKTTNATMLENKYSLTLALGHAIWYHAGTGQIIQVPTFVKEKLAPEIRTETQLFFLCHMVGPFLQRFNSDISRVVMDITLTLYELLAHIDKLQPHLQYVDPICDLLYHIKYMFVGDIMKNEVENVIRKLRPALQMRLRFITHLNVDQINTA
Length1332
PositionTail
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.09
Grand average of hydropathy-0.053
Instability index41.94
Isoelectric point6.92
Molecular weight152572.80
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08650
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.97|      84|     293|     928|    1030|       1
---------------------------------------------------------------------------
  928- 1030 (116.09/119.54)	EKFAPEEASGTyggtipvYLSNVCLRIIPVL...DVVVHRhlEIPQVSKNLEQLLEHIGYL...YKFHDrPI.TFLYntlHYYELKLRDkpLLKRKLVNAVlgslKDVRP
 1222- 1312 (130.88/82.57)	EKLAPEIRTET.......QLFFLCHMVGPFLqrfNSDISR..VVMDITLTLYELLAHIDKLqphLQYVD.PIcDLLY...HIKYMFVGD..IMKNEVENVI....RKLRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.88|      40|     108|     409|     451|       2
---------------------------------------------------------------------------
  409-  451 (68.47/62.34)	PEKEP.LPVPDWTRAH......STH.QMAVV.CIWMHLLKKAEtdNKTmSMP
  513-  561 (53.41/36.64)	PNGNPgTPLPTMPLSMcildslTLHcKMSVIhSIVTHVAKLAQ..NKT.NLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.59|      23|      48|     177|     203|       3
---------------------------------------------------------------------------
  135-  153 (26.35/13.43)	........VREIMKGCREKAHSLPMKL
  177-  203 (39.82/38.91)	SLLPayfiVTEIQKDYPDNNHYPHWEL
  228-  248 (39.41/26.42)	SMLP....VVEF.SGYADHLINP.WRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.43|      27|      74|     776|     802|       5
---------------------------------------------------------------------------
  776-  802 (50.13/32.77)	NDIVSHFSVPGAP.LFLCLLWKIIFETN
  852-  879 (44.30/28.07)	NDIVWKYNIVTIDrLVLCLVLRPNLDGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.19|      33|      39|    1090|    1122|       7
---------------------------------------------------------------------------
 1090- 1122 (61.09/32.13)	PSAH.ALYVTCVELM..SLPFPP.NVVGNSLLEIITS
 1128- 1164 (47.10/23.31)	PTTKiQLWVNAVGLImaALPDPYwNVIHDKILELITS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      16|      43|     715|     730|       8
---------------------------------------------------------------------------
  715-  730 (29.40/19.10)	KELLTTIMTNTPHNWS
  755-  770 (27.88/17.72)	KQLLKKFVEEEYRKWS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08650 with Med23 domain of Kingdom Metazoa
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